Heterologous vaccine

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A heterologous vaccine is a type of live vaccine where one virus is introduced to provide protection against another virus.

An example is the administration of vaccinia to provide protection against variola.

Like all live vaccines, it has the advantage that it replicates in the body, and therefore reduces the need for booster shots. It has the disadvantage that a potential pathogen is introduced into the body.

It can be combined with the attenuation strategy in vaccine design.[1]


  1. ^ Ho SY, Chua SQ, Foo DG et al. (January 2008). "Highly attenuated Bordetella pertussis strain BPZE1 as a potential live vehicle for delivery of heterologous vaccine candidates". Infect. Immun. 76 (1): 111–9. doi:10.1128/IAI.00795-07. PMC 2223651. PMID 17954727.