Karachi South District is the economic backbone of the country. It has Head Offices of many Corporations, Companies and Banks. Governor House, Chief Minister House, Sindh Assembly, High Court, Embassies and Consulates of different countries and other government offices are also located there.
The District was abolished in 2000 and divided into three towns namely Lyari Town, Saddar Town and Jamshed Town. On 11 July 2011 Sindh Government restored again Karachi South District.
Sindhi and Baloch form majority in the district followed by Muhajirs, Gujaratis and others.