MT-ATP8

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ATP synthase F0 subunit 8
Identifiers
Symbols ATP8 ; ATPase8; MTATP8
External IDs OMIM516070 HomoloGene124425 GeneCards: ATP8 Gene
Orthologs
Species Human Mouse
Entrez 4509 n/a
Ensembl ENSG00000228253 n/a
UniProt P03928 n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) Chr MT:
0.01 – 0.01 Mb
n/a
PubMed search [1] n/a
ATP synthase protein 8 (metazoa)
Identifiers
Symbol ATP-synt_8
Pfam PF00895
Pfam clan CL0255
InterPro IPR001421
Plant ATP synthase F0 subunit 8
Identifiers
Symbol YMF19
Pfam PF02326
Pfam clan CL0255
InterPro IPR003319
Fungal ATP synthase protein 8 (A6L)
Identifiers
Symbol Fun_ATP-synt_8
Pfam PF05933
Pfam clan CL0255
InterPro IPR009230

ATP synthase protein 8 is an protein that in humans is encoded by the MT-ATP8 gene. It is a subunit of mitochondrial ATP synthase.

This subunit appears to be an integral component of the stator stalk in yeast mitochondrial F-ATPases.[1] The stator stalk is anchored in the membrane, and acts to prevent futile rotation of the ATPase subunits relative to the rotor during coupled ATP synthesis/hydrolysis. This subunit may have an analogous function in Metazoa. Subunit 8 differs in sequence between Metazoa, plants and fungi).


References[edit]

  1. ^ Stephens AN, Khan MA, Roucou X, Nagley P, Devenish RJ (May 2003). "The molecular neighborhood of subunit 8 of yeast mitochondrial F1F0-ATP synthase probed by cysteine scanning mutagenesis and chemical modification". J. Biol. Chem. 278 (20): 17867–75. doi:10.1074/jbc.M300967200. PMID 12626501. 

Further reading[edit]


This article incorporates text from the public domain Pfam and InterPro IPR001421