Medical Research Council (United Kingdom)
|Medical Research Council|
|Type||Non-Departmental Government Body|
|Purpose/focus||Co-ordinating and funding medical research in the United Kingdom|
|Region served||United Kingdom|
|Chief Executive||Sir John Savill|
|Chairman||Sir John Chisholm|
|Main organ||MRC Council|
|Parent organization||Department for Business, Innovation and Skills
Research Councils UK
|Affiliations||AHRC, BBSRC, EPSRC, ESRC, NERC, STFC, TSB, UKSA|
|Budget||c. £350 million|
The Medical Research Council (the MRC) is a publicly funded government agency responsible for co-ordinating and funding medical research in the United Kingdom. It is one of seven Research Councils in the UK and is answerable to, although politically independent from, the Department for Business, Innovation and Skills.
The MRC focuses on high-impact research and has provided the financial support and scientific expertise behind a number of medical breakthroughs, including the development of penicillin and the discovery of the structure of DNA. Research funded by the MRC has produced 29 Nobel Prize winners to date.
The MRC was founded as the Medical Research Committee and Advisory Council in 1913, with its prime role being the distribution of medical research funds under the terms of the National Insurance Act 1911. This was a consequence of the recommendation of the Royal Commission on Tuberculosis, which recommended the creation of a permanent medical research body. The mandate was not limited to tuberculosis, however.
In 1920, it became the Medical Research Council under Royal Charter. A supplementary Charter was formally approved by the Queen on 17 July 2003.
In August 2012 the creation of the MRC-NIHR Phenome Centre, a research centre for personalised medicine, was announced. The centre will be based at GlaxoSmithKline's research and development facility in Harlow, Essex, inheriting the anti-doping facilities used to test samples during the 2012 Olympic and Paralympic Games. The centre will be led by Imperial College London and will be funded with two five-year grants of £5 million from the Medical Research Council and the National Institute for Health Research.
Important work carried out under MRC auspices has included:
- the identification of the dietary cause of rickets by Sir Edward Mellanby;
- the discovery, in 1918, that influenza is caused by a virus;
- the description of neurotransmission and the first neurotransmitter, acetylcholine, by Sir Henry Hallett Dale and Otto Loewi, leading to a Nobel Prize for Physiology or Medicine in 1936;
- the development of penicillin by Sir Alexander Fleming, Sir Ernst Boris Chain and Lord Florey, gaining them the 1945 Nobel Prize;
- linkage of lung cancer to tobacco smoking by Sir Richard Doll and Sir Austin Bradford Hill in the British doctors study, published in 1956;
- the discovery of the structure of DNA by James D. Watson, Francis Crick, Rosalind Franklin and Professor Maurice Wilkins. Three would receive the 1962 Nobel Prize for Physiology and Medicine for their discovery;
- the development of magnetic resonance imaging in 1973 by Professor Peter Mansfield and independently by Paul Lauterbur. This would lead to the 2003 Nobel Prize;
- the development of monoclonal antibodies by César Milstein and Georges Köhler in 1975 (1984 Nobel Prize);
- the identification, in 1983, of folic acid as a preventive measure for spina bifida and neural tube defects;
- the conducting of large studies in the 1970s and 1980s which established that aspirin can decrease the risk of cardiovascular disease;
- the publication of the genome of C. elegans, the first multicellular organism to receive this treatment, in 1998;
- the ongoing Heart Protection Study, showing benefits of primary prevention with simvastatin in patients at high risk for cardiovascular disease;
- Dr Venki Ramakrishnan of the MRC Laboratory of Molecular Biology winning the Nobel Prize for Chemistry in 2009 for showing how ribosomes, the tiny protein-making factories inside cells, function at the atomic level;
- the discovery that early treatment of HIV-infected babies with anti-retroviral therapy can dramatically increase their chances of survival;
- the development of a test for detecting infectious prions on surgical instruments which is more accurate than previous tests and 100 times faster;
- the identification of the second ever genetic variant associated with obesity; and
- the finding that high quality surgery combined with a short course of radiotherapy can halve the rate of recurrence of colorectal cancer.
Scientists associated with the MRC have received a total of 29 Nobel Prizes, all in either Physiology or Medicine or Chemistry
Organisation and leadership
|This section does not cite any references or sources. (January 2012)|
The MRC is one of seven Research Councils and since 6 June 2009 has been answerable to, although politically independent from, the Department for Business, Innovation and Skills. In the past, the MRC has been answerable to the Office of Science and Innovation, part of the Department of Trade and Industry.
The MRC is governed by a council of 14 members, which convenes every two months. Its Council, which directs and oversees corporate policy and science strategy, ensures that the MRC is effectively managed, and makes policy and spending decisions. Council members are drawn from industry, academia, government and the NHS. Members are appointed by the Secretary of State for Business, Innovation and Skills. Daily management is in the hands of the Chief Executive. Members of the council also chair specialist boards on specific areas of research. For specific subjects, the council convenes committees.
Chief Executive Officers
As Chief Executive Officers (originally secretaries) served:
- 1914-33: Sir Walter Morley Fletcher
- 1933-49: Sir Edward Mellanby
- 1949-68: Sir Harold Himsworth
- 1968-77: Sir John Gray
- 1977-87: Sir James L. Gowans
- 1987-96: Sir Dai Rees
- 1996-2003: Professor Sir George Radda
- 2003-2007: Professor Colin Blakemore
- 2007-2010: Professor Sir Leszek Borysiewicz
- 2010–present: Professor Sir John Savill
- 1913-1916: The Rt Hon. Lord Moulton
- 1916-1920: Major The Hon. Waldorf Astor
- 1920-1924: The Viscount Goschen
- 1924: The Rt Hon. Edward F.L. Wood
- 1924-1929: The Rt Hon. the Earl of Balfour
- 1929-1934: The Rt Hon. Viscount D'Abernon
- 1934-1936: The Most Hon. The Marquess of Linlithgow
- 1936-1948: Lord Balfour of Burleigh
- 1948-1951: The Rt Hon. Viscount Addison
- 1952-1960: The Earl of Limerick
- 1960-1961: The Rt Hon. The Viscount Amory
- 1961-1965: The Rt Hon. Lord Shawcross
- 1965-1969: The Rt Hon. The Viscount Amory
- 1969-1978: His Grace the Duke of Northumberland
- 1978-1982: The Rt Hon. The Lord Shepherd
- 1982-1990: The Rt Hon. The Earl Jellicoe
- 1990-1998: Sir David Plastow
- 1998-2006: Sir Anthony Cleaver
- 2006-2012: Sir John Chisholm
- 2012-present: Donald Brydon, CBE
Institutes, centres and units
The MRC has 27 units and three institutes in the UK and one unit in each of The Gambia and Uganda. It also has 26 centres offering partnerships with UK universities to develop centres of scientific excellence. Three MRC-funded 'lifelong health' research centres were announced in 2008 as part of the Lifelong Health and Wellbeing programme - the Biotechnology and Biological Sciences Research Council, the Engineering and Physical Sciences Research Council and the Economic and Social Research Council.
The following is a list of the MRC's current institutes, centres and units:
- MRC/University of Birmingham Centre for Immune Regulation (based at the University of Birmingham)
- MRC/University of Sussex Centre in Genome Damage and Stability (based at the University of Sussex)
- MRC Integrative Epidemiology Unit
- MRC Biostatistics Unit
- MRC Cancer Unit
- MRC Centre for Behavioural and Clinical Neuroscience Institute (BCNI) (based at the University of Cambridge)
- MRC Centre for Stem Cell Biology and Regenerative Medicine (based at the University of Cambridge)
- MRC Cognition and Brain Sciences Unit (CBSU)
- MRC Epidemiology Unit
- MRC Human Nutrition Research
- MRC Laboratory of Molecular Biology (LMB)
- MRC Metabolic Diseases Unit
- MRC Mitochondrial Biology Unit
- MRC Centre for Neuropsychiatric Genetics and Genomics (based at Cardiff University)
- MRC Protein Phosphorylation Unit (based at the University of Dundee)
- MRC Centre for Cognitive Ageing and Cognitive Epidemiology (based at the University of Edinburgh)
- MRC Centre for Regenerative Medicine (based at the University of Edinburgh)
- MRC Centre for Reproductive Health, Edinburgh
- MRC Human Genetics Unit
- MRC Scottish Collaboration for Public Health Research and Policy
- MRC/University of Edinburgh Centre for Inflammation Research (based at the University of Edinburgh)
- MRC/UVRI Uganda Research Unit on AIDS
- MRC (UK) The Gambia
- MRC/CSO Social and Public Health Sciences Unit (based at the University of Glasgow)
- MRC Institute of Hearing Research (based at the University of Glasgow)
- MRC-University of Glasgow Centre for Virus Research (based at the University of Glasgow)
- MRC Mammalian Genetics Unit
- Research Complex at Harwell (RCaH)
- MRC Toxicology Unit (based at the University of Leicester)
- MRC Centre for Drug Safety Science (based at the University of Liverpool)
- MRC Asthma UK Centre in Allergic Mechanisms of Asthma (based at King's College London)
- MRC Cell Biology Unit (based at University College London)
- MRC Centre of Epidemiology for Child Health (based at University College London)
- MRC Centre for Developmental Neurobiology (based at King's College London)
- MRC Centre for Molecular Bacteriology and Infection (based at Imperial College London)
- MRC Centre for Neuromuscular Diseases (based at University College London)
- MRC Centre for Outbreak Analysis and Modelling (based at Imperial College London)
- MRC Centre for Transplantation (based at King's College London)
- MRC Clinical Sciences Centre (CSC) (based at Imperial College London)
- MRC Clinical Trials Unit (CTU)
- The Crucible Centre (based at University College London)
- MRC-HPA Centre for Environment and Health (jointly based at King's College London and Imperial College London)
- MRC International Nutrition Group (based at the London School of Hygiene & Tropical Medicine)
- MRC National Institute for Medical Research (NIMR) including the MRC Biomedical NMR Centre (planned to move to the new Francis Crick Institute in 2015, a partnership between the MRC, Cancer Research UK, Imperial College London, King's College London, the Wellcome Trust and University College London)
- MRC Prion Unit (based at University College London)
- MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre (based at King's College London)
- MRC Unit for Lifelong Health and Ageing, home of the National Survey of Health & Development
- MRC/University College London Centre for Medical Molecular Virology (based at University College London)
- Centre for Brain Ageing and Vitality (based at Newcastle University)
- MRC Institute of Hearing Research (based at the University of Nottingham)
- MRC Anatomical Neuropharmacology Unit
- MRC/Cancer Research UK/BHF Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU)
- MRC/Cancer Research UK Gray Institute for Radiation Oncology and Biology (based at the University of Oxford)
- MRC Centre for Genomics and Global Health
- MRC Functional Genomics Unit (based at the University of Oxford)
- MRC Human Immunology Unit (based at the University of Oxford)
- MRC Molecular Haematology Unit
- MRC Centre for Developmental and Biomedical Genetics (based at the University of Sheffield)
- MRC Lifecourse Epidemiology Unit
- "Records created or inherited by the Medical Research Council". The National Archives. Retrieved 28 February 2012.
- "London 2012 legacy to include medical research centre". Times Higher Education. 1 August 2012. Retrieved 1 August 2012.
- "Legacy for anti-doping centre". BBC News. 1 August 2012. Retrieved 1 August 2012.
- "Complete Dictionary of Scientific Biography: Mellanby, Edward". Encyclopedia.com. Retrieved 28 February 2012.
- "Social History of Medicine - Uses of a Pandemic: Forging the Identities of Influenza and Virus Research in Interwar Britain". Oxford University Press. 15 December 2011. Retrieved 28 February 2012.
- Bud, Robert (2007). Penicillin Triumph and Tragedy. Oxford University Press. ISBN 978-0-19-925406-4.
- Doll, R.; Peto, R.; Boreham, J.; Sutherland, I. (2005). "Mortality from cancer in relation to smoking: 50 years observations on British doctors". British Journal of Cancer 92 (3): 426–429. doi:10.1038/sj.bjc.6602359. PMC 2362086. PMID 15668706.
- Torsten, Krude; Klug, Aaron (2004). Changing Science and Society. Cambridge University Press. pp. 3–26. ISBN 0-521-82378-1.
- "The Nobel Prize in Physiology or Medicine 2003". Nobelprize.org. Retrieved 28 February 2012.
- "Therapeutic Antibodies and the LMB". MRC Laboratory of Molecular Biology. Retrieved 28 February 2012.
- Centers for Disease Control (CDC) (1991). "Use of folic acid for prevention of spina bifida and other neural tube defects--1983-1991". MMWR. Morbidity and mortality weekly report 40 (30): 513–516. PMID 2072886.
- Collins, R.; Armitage, J.; Parish, S.; Sleigh, P.; Peto, R.; Heart Protection Study Collaborative Group (2003). "MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: A randomised placebo-controlled trial". Lancet 361 (9374): 2005–2016. PMID 12814710.
- "The Nobel Prize in Chemistry 2009". Nobelprize.org. Retrieved 28 February 2012.
- Loos, R. J. F. (2009). "Recent progress in the genetics of common obesity". British Journal of Clinical Pharmacology 68 (6): 811–829. doi:10.1111/j.1365-2125.2009.03523.x. PMC 2810793. PMID 20002076.
- "Press release: Doctors more than halve local relapse of rectal cancer". http://insciences.org. 6 March 2009. Retrieved 28 February 2012.
- "Nobel Prize Winners". Medical Research Council. Retrieved 28 February 2012.
- "RCUK: Medical Research Council". Research Councils UK. Retrieved 28 February 2012.
- "MRC Council". Medical Research Council. Retrieved 28 February 2012.
- "Units, centres and institutes". Medical Research Council. Retrieved 5 November 2010.
- "Press release: £250 million commitment to UKCMRI". MRC National Institute for Medical Research. 26 March 2010. Retrieved 12 August 2010.
- MRC official website
- Research Councils UK
- Human Genetic Unit
- Annual Reviews
- Social & Public Health Sciences Unit
- NIMR official website