PKLR

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Pyruvate kinase, liver and RBC
Protein PKLR PDB 1liu.png
PDB rendering based on 1liu.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PKLR ; PK1; PKL; PKR; PKRL; RPK
External IDs OMIM609712 MGI97604 HomoloGene37286 ChEMBL: 1075126 GeneCards: PKLR Gene
EC number 2.7.1.40
RNA expression pattern
PBB GE PKLR 207858 s at tn.png
PBB GE PKLR 210451 at tn.png
PBB GE PKLR 222078 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5313 18770
Ensembl ENSG00000143627 ENSMUSG00000041237
UniProt P30613 E9Q509
RefSeq (mRNA) NM_000298 NM_001099779
RefSeq (protein) NP_000289 NP_001093249
Location (UCSC) Chr 1:
155.26 – 155.27 Mb
Chr 3:
89.14 – 89.15 Mb
PubMed search [1] [2]

Pyruvate kinase isozymes R/L is an enzyme that in humans is encoded by the PKLR gene.[1][2]

The protein encoded by this gene is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Alternatively spliced transcript variants encoding distinct isoforms have been described.[2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article
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GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article
|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit|]]
Glycolysis and Gluconeogenesis edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534". 

See also[edit]

References[edit]

  1. ^ Tani K, Fujii H, Tsutsumi H, Sukegawa J, Toyoshima K, Yoshida MC, Noguchi T, Tanaka T, Miwa S (Apr 1987). "Human liver type pyruvate kinase: cDNA cloning and chromosomal assignment". Biochem Biophys Res Commun 143 (2): 431–8. doi:10.1016/0006-291X(87)91372-6. PMID 3566732. 
  2. ^ a b "Entrez Gene: PKLR pyruvate kinase, liver and RBC". 

Further reading[edit]