Polyhexanide

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Polyhexanide
Polyhexanide.svg
Names
Other names
Polyhexamethylene biguanide; Polyhexamethylene guanide; Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene); Poly(hexamethylenebiguanide); Polihexanide
Identifiers
Abbreviations PHMB
ATC code D08AC05
28757-47-3 N
32289-58-0 (HCl) YesY
28757-48-4 N
ChemSpider  YesY
UNII 322U039GMF YesY
Properties
(C8H17N5)n
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use[1] it is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, and Omnicide.[2] PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).[3]

Some products containing PHMB are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, scopy, first aid, surface disinfection, and linen disinfection.[4]

Branded as Baquacil, it also has an application as a swimming-pool and spa water sanitizer in place of chlorine- or bromine-based products.

PHMB is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products.

The PHMB hydrochloride salt (solution) is used in the majority of formulations.

See also[edit]

References[edit]

  1. ^ Ansorg R, Rath PM, Fabry W (2003). "Inhibition of the anti-staphylococcal activity of the antiseptic polihexanide by mucin". Arzneimittel-Forschung 53 (5): 368–71. doi:10.1055/s-0031-1297121. PMID 12854364. 
  2. ^ International Drug Names: Polihexanide
  3. ^ Maribeth Cousin, Kimberly Restivo, Chelsea Rodriguez, and Justin Lien. USP Antimicrobial Effectiveness Test (GLP). Elkhorn, WI: Geneva Laboratories. 2013. http://steriwebrx.com/files/STERIWEB-FINAL-JN13J1514.pdf
  4. ^ Nusept