Polyhexanide

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Polyhexanide
Polyhexanide.svg
Identifiers
Abbreviations PHMB
CAS number 28757-47-3 N, 32289-58-0 (HCl) YesY, 28757-48-4
UNII 322U039GMF YesY
ATC code D08AC05
Properties
Molecular formula (C8H17N5)n
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use[1] it is spelled polihexanide (INN) and sold under names such as Lavasept and Serasept.[2]

Some products containing PHMB are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, scopy, first aid, surface disinfection, and linen disinfection.[3]

Branded as Baquacil, it also has an application as a swimming-pool and spa water sanitizer in place of chlorine- or bromine-based products.

PHMB is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products.

The PHMB hydrochloride salt (solution) is used in the majority of formulations.

See also[edit]

References[edit]

  1. ^ Ansorg R, Rath PM, Fabry W (2003). "Inhibition of the anti-staphylococcal activity of the antiseptic polihexanide by mucin". Arzneimittel-Forschung 53 (5): 368–71. doi:10.1055/s-0031-1297121. PMID 12854364. 
  2. ^ International Drug Names: Polihexanide
  3. ^ Nusept