Ethacridine lactate

Ethacridine lactate

Systematic (IUPAC) name
7-ethoxyacridine-3,9-diamine; 2-hydroxypropanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	1837-57-6 N
ATC code	B05CA08 D08AA01
PubChem	CID 15789
ChemSpider	15012 Y
KEGG	D01248 Y
ChEMBL	CHEMBL582355 Y
Chemical data
Formula	C18H21N3O4
Mol. mass	343.37
SMILES	eMolecules & PubChem
InChI InChI=1S/C15H15N3O.C3H6O3/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13;1-2(4)3(5)6/h3-8H,2,16H2,1H3,(H2,17,18);2,4H,1H3,(H,5,6) Y Key:IYLLULUTZPKQBW-UHFFFAOYSA-N Y
N (what is this?)  (verify)

Ethacridine lactate (ethacridine monolactate monohydrate, acrinol, trade name Rivanol) is an aromatic organic compound based on acridine. Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.

Its primary use is as an antiseptic in solutions of 0.1%.

Ethacridine is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a foley catheter. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used. Ethacridine as an abortifacient is found to be safer and better tolerated than 20% hypertonic saline.

References

• Tien, K. H. (1983). "Intraamniotic injection of ethacridine for second-trimester induction of labor". Obstetrics and gynecology 61 (6): 733–736. PMID 6843933. 
• Merck Index, 11th Ed., 3668.