Ethacridine lactate

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Ethacridine lactate
Ethacridinlactat.svg
Systematic (IUPAC) name
7-ethoxyacridine-3,9-diamine; 2-hydroxypropanoic acid
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Identifiers
CAS number 1837-57-6 N
ATC code B05CA08 D08AA01
PubChem CID 15789
ChemSpider 15012 YesY
KEGG D01248 YesY
ChEMBL CHEMBL582355 YesY
Chemical data
Formula C18H21N3O4 
Mol. mass 343.37
 N (what is this?)  (verify)

Ethacridine lactate (ethacridine monolactate monohydrate, acrinol, trade name Rivanol) is an aromatic organic compound based on acridine. Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.

Its primary use is as an antiseptic in solutions of 0.1%.

Ethacridine is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a foley catheter. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used. Ethacridine as an abortifacient is found to be safer and better tolerated than 20% hypertonic saline.

References[edit]

  • Tien, K. H. (1983). "Intraamniotic injection of ethacridine for second-trimester induction of labor". Obstetrics and gynecology 61 (6): 733–736. PMID 6843933.  edit
  • Merck Index, 11th Ed., 3668.