Ribonuclease III
| Ribonuclease III domain | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Ribonuclease III structure interacting with double stranded RNA. | |||||||||||
| Identifiers | |||||||||||
| Symbol | RNase_III | ||||||||||
| Pfam | PF00636 | ||||||||||
| InterPro | IPR000999 | ||||||||||
| PROSITE | PDOC00448 | ||||||||||
| SCOP2 | 1jfz / SCOPe / SUPFAM | ||||||||||
| |||||||||||
RNase III is a type of ribonuclease that specifically binds to and cleaves double-stranded RNA (dsRNA).[1] There are four subdivisions, known as Class 1, 2, 3, and 4.
Prokaryotic ribonuclease III (EC 3.1.26.3) (gene rnc)[2] is an enzyme that digests double-stranded RNA. It is involved in the processing of ribosomal RNA precursors and of some mRNAs.
- Class 1 RNases III are largely found in bacteria, bacteriophage, and some fungi. Among the RNases III in the class are the rnc from E. coli, Pac1p from S. pombe, and Rnt1p from S. cerevisiae. Class 1 RNases III process precursors to ribosomal RNA, and in the case of fungi, process precursors to small nuclear RNA (snRNA) and small nucleolar RNA (snoRNA).
- Class 2 RNases III include the Drosha family of enzymes known to function in maturation of precursors to miRNA.[3]
- Class 3 RNases III include the Dicer family of enzymes known to function in RNA interference (RNAi).[4]
- Class 4 RNases III called Mini-III are homodimeric enzymes and consist solely of the RNase III domains.[5]
Human proteins containing this domain
See also
External links
- RNase+III at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- EC 3.1.26.3
References
- ^ Lamontagne, B.; Larose, S.; Boulanger, J.; Elela, S. (2001). "The RNase III family: A conserved structure and expanding functions in eukaryotic dsRNA metabolism". Current issues in molecular biology. 3 (4): 71–78. PMID 11719970.
- ^ Nashimoto H, Uchida H (1985). "DNA sequencing of the Escherichia coli ribonuclease III gene and its mutations". Mol. Gen. Genet. 201 (1): 25–29. doi:10.1007/bf00397981. PMID 3903434.
- ^ Filippov V, Solovyev V, Filippova M, Gill SS (Mar 2000). "A novel type of RNase III family proteins in eukaryotes". Gene. 245 (1): 213–221. doi:10.1016/S0378-1119(99)00571-5. PMID 10713462.
- ^ Bernstein E, Caudy AA, Hammond SM, Hannon GJ (2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference". Nature. 409 (6818): 363–6. doi:10.1038/35053110. PMID 11201747.
- ^ Glow, D.; Pianka, D.; Sulej, A. A.; Kozlowski, Lukasz P.; Czarnecka, J.; Chojnowski, G.; Skowronek, K. J.; Bujnicki, J. M. (2015). "Sequence-specific cleavage of dsRNA by Mini-III RNase". Nucleic Acids Research. 43 (5): 2864–2873. doi:10.1093/nar/gkv009. ISSN 0305-1048. PMID 25634891.
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