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Syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
Symbols SNTB1 ; 59-DAP; A1B; BSYN2; DAPA1B; SNT2; SNT2B1; TIP-43
External IDs OMIM600026 MGI101781 HomoloGene9618 GeneCards: SNTB1 Gene
RNA expression pattern
PBB GE SNTB1 208608 s at tn.png
PBB GE SNTB1 214708 at tn.png
More reference expression data
Species Human Mouse
Entrez 6641 20649
Ensembl ENSG00000172164 ENSMUSG00000060429
UniProt Q13884 Q99L88
RefSeq (mRNA) NM_021021 NM_016667
RefSeq (protein) NP_066301 NP_057876
Location (UCSC) Chr 8:
121.55 – 121.83 Mb
Chr 15:
55.64 – 55.91 Mb
PubMed search [1] [2]

Beta-1-syntrophin is a protein that in humans is encoded by the SNTB1 gene.[1][2][3]


Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally related genes.[3]


SNTB1 has been shown to interact with Dystrophin.[4]


  1. ^ Ahn A, Yoshida M, Anderson M, Feener C, Selig S, Hagiwara Y et al. (Jun 1994). "Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24". Proc Natl Acad Sci U S A 91 (10): 4446–50. doi:10.1073/pnas.91.10.4446. PMC 43802. PMID 8183929. 
  2. ^ Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (Mar 1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins". Oncogene 16 (5): 643–54. doi:10.1038/sj.onc.1201567. PMID 9482110. 
  3. ^ a b "Entrez Gene: SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)". 
  4. ^ Ahn A, Kunkel L (Feb 1995). "Syntrophin binds to an alternatively spliced exon of dystrophin". J. Cell Biol. 128 (3): 363–71. doi:10.1083/jcb.128.3.363. PMC 2120343. PMID 7844150. 

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