In 2009, the ToonSeum established its NEMO Award, given to notable individuals "for excellence in the cartoon arts". Recipients to date include veteran comic-book artist Ron Frenz, editorial and comic-strip artist Dick Locher, and comics artist, editorial cartoonist and artists' rights advocate Jerry Robinson.
In May 2013, ToonSeum hosted the two day North American Conference of the National Cartoonists Society. In that same month, plans for expansion of the museum were announced.
After 7 years as the volunteer director and founder, Joe Wos stepped down from the ToonSeum.