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Santa Ono
FCAHS
Ono in 2024
15th President of the University of Michigan
Incumbent
Assumed office
October 14, 2022
Preceded byMary Sue Coleman (acting)
15th President and Vice-Chancellor of the University of British Columbia
In office
August 15, 2016 – October 13, 2022
ChancellorLindsay Gordon
Steven Point
Preceded byMartha Piper (acting)
Succeeded byDeborah Buszard (acting)
28th President of the University of Cincinnati
In office
August 2012 – July 2016
Preceded byGregory H. Williams
Succeeded byBeverly Davenport (acting)
Personal details
Born
Santa Jeremy Ono

(1962-11-23) November 23, 1962 (age 61)
Vancouver, British Columbia, Canada
Citizenship
Spouse
Wendy Yip
​
(m. 1989)​
Children2
ResidencePresident's House
Education
Scientific career
Fields
Institutions
ThesisMajor histocompatibility complex association of insulin-dependent diabetes in the BB rat (1991)
Doctoral advisor
  • Abraham Fuks
  • Ronald Guttmann
Notable studentsPaola Arlotta

Santa Jeremy Ono FCAHS (Japanese: 小野 三太; born November 23, 1962)[1] is a Canadian-American immunologist and academic administrator who has been serving as the 15th president of the University of Michigan since October 2022.[2]

Ono served as the 15th president of the University of British Columbia from 2016 to 2022 and the 28th president of the University of Cincinnati from 2012 to 2016.[3] Previously, as a faculty member of Johns Hopkins University, Harvard University, University College London, and Emory University, Ono contributed to the field of gene regulation in the immune system and to the understanding of inflammation in the eye.[4]

Early life and education

[edit]

Born in 1962, Santa Ono is the son of mathematician Takashi Ono, who immigrated to the United States from Japan in the late 1950s. Ono was born in Vancouver, British Columbia, Canada, where his father worked as an assistant professor of mathematics at the University of British Columbia from 1961 to 1964. As a result, Ono acquired United States citizenship by jus sanguinis and Canadian citizenship by jus soli.[1]

Ono was raised in Philadelphia, Pennsylvania, and Towson, Maryland, where his father worked as a faculty member at the University of Pennsylvania from 1964 to 1969 and at Johns Hopkins University from 1969 to 2011, respectively.[1][5] His older brother is Momoro Ono and his younger brother is Ken Ono.[6]

Ono received a Bachelor of Arts with a major in biological science from the University of Chicago in 1984 and a Doctor of Philosophy in experimental medicine from McGill University in Canada in 1991.[7]

Career

[edit]

Academic career

[edit]

Ono completed his postdoctoral fellowship at Harvard University supported by the Helen Hay Whitney Foundation.[8] Ono discovered that certain genes related to immune function (class I and II MHC) are more active on insulin-producing cells in the pancreas, which may influence diabetes risk.[9][10] He also studied how these MHC genes are controlled, finding that specific DNA elements and transcription factors (proteins that help turn genes on or off) play key roles.[11][12] His lab discovered a factor, NFX1, important for nerve cell development and mRNA transport, which may also help regulate protein recycling related to diseases like Parkinson’s and Huntington's.[13][14]

Ono's lab also explored the role of the HMGA protein, which helps activate several genes, including those tied to immune response and vision. Using mouse models, they showed that certain HMGA protein fusions can lead to the growth of benign fat tumors and obesity.[15] In 2007, Ono's lab studied how specific molecules called beta-chemokines contribute to eye inflammation and how they interact with immune cells to worsen conditions like macular degeneration (AMD). They also identified autoantibodies that may serve as biomarkers to track AMD and similar eye diseases.[16][17]

While at University College London, Ono served as associate dean of students and as a member of the University College London Council.[18] From 2006 to 2010, Ono served as senior vice provost for undergraduate education and academic affairs at Emory University in Atlanta, Georgia.[19][20]

University of Cincinnati

[edit]

In June 2010, Ono was named senior vice president for academic affairs and university provost at the University of Cincinnati, with oversight of budgets, personnel, and planning.[21][22]

In 2012, Ono was named the 28th president of the University of Cincinnati in Ohio, becoming the first Asian-American president of that university.[18] U Square at the Loop, a $78 million mixed use development, was opened during his presidency.[23]

In January 2015, Inside Higher Education named Ono as "the nation's most notable college president for 2015".[24] In December 2015, an article on Upworthy profiled Ono as sixth in the list of "9 high-profile CEOs who did positive things in 2015".[25]

University of British Columbia

[edit]

On June 15, 2016, Ono was named the 15th president and vice chancellor of the University of British Columbia in Canada, effective August 15.[26] He was re-appointed for a second five-year term on August 11, 2020.[27]

In February 2017, Ono reinstated John Furlong as keynote speaker for a university fundraiser despite allegations of Furlong's abuse of Indigenous children during his time as a teacher in a remote community.[28][29][30] Furlong's participation sparked protests from UBC students and activists, including some of his alleged victims.[28] This incident led to the resignation of the only Indigenous member of UBC's Sexual Assault Policy Committee.[31] Ono's decision to reinvite Furlong followed reported pressure from wealthy donors.[29]

In July 2019, Amazon announced plans to establish Canada's first "Cloud Innovation Centre" at UBC.[32] The project proceeded without community consultation.[33] Contract details were withheld until a student group obtained them through a freedom of information request. The documents showed that the Ono administration followed Amazon's directive to keep $3 million in funding confidential.[34]

In October 2019, at least six students was given medical attentions for suspected drugging incidents at a fraternity party.[35] Following this, a female professor faced online abuse after criticizing the fraternities involved.[36] However, the university administration, under the Ono chancellorship, responded and emphasized freedom of expression rather than condemning the harassment against the professor, affirming its "commitment to freedom of expression and academic freedom".[37]

During Ono's tenure, the university hosted multiple controversial speakers promoting white supremacist, Islamophobic, and neo-Nazi movements, often invited by student groups with extreme views.[38] Ono inaccurately claimed equal community support for an anti-trans speaker event,[39] leading to the Vancouver Pride Society's decision in July 2019 to ban UBC's participation in the Vancouver Pride parade.[40]

University of Michigan

[edit]

On July 13, 2022, Ono was named as the 15th president of the University of Michigan, with his term beginning on October 13, 2022.[41][42] He became the first Asian American to lead the university.[2] In October 2023, Ono received a 4% raise in base salary, increasing it from US$975,000 to US$1,014,000 annually.[43]

On October 17, 2024, the university's Board of Regents voted unanimously to extend Ono's contract by an additional eight years, through October 1, 2032.[44][45] The extension also increased Ono's base salary to US$1.3 million per year, marking a 33% rise since he started his tenure two years ago in 2022.[46]

Response to labor union protest

[edit]

Ono's inauguration ceremony on March 7, 2023 as president of the University of Michigan,[47] was marked both by protests from the Graduate Employees' Organization [48] and administrators' insistence that students write and perform poetry praising his leadership style.[49] The Graduate Employees' Organization (GEO) is a labor union that represents about 2,300 graduate student instructors and graduate assistants. On March 29, 2023 — 22 days into his presidency — Ono led the University of Michigan into what became the longest labor strike in the institution's history. A majority of instructors in GEO went on strike because their 24,000 dollar compensation package was not adjusted for the 38,000 dollar cost of living in Ann Arbor.[50]

Ono responded to the strike by seeking but failing to win an injunction against GEO membership,[51] with his administrators claiming in court that strikers were causing "irreparable harm to the university."[52] When Ono was challenged by union members in a downtown restaurant on April 20, he called police to arrest and handcuff the protesters — off campus.[53] In response, Ono pursued felony charges against the protestors, but the Washtenaw County Prosecuting Attorney declined to press charges for lack of evidence that strike actions violated protected speech. Footage of the detentions racked up over 1.4 million views on social media.[54] Ono further withheld hundreds of thousands of dollars in compensation from strikers, directed leadership to hire other students as strikebreakers, and caused administrators to invent the final grades of students they had not taught. These actions and others prompted the Higher Learning Commission to announce an investigation into possible academic misconduct by university leadership,[55] which was later dropped. As the strike extended into the spring, Ono cancelled attendance at scheduled campus events, became less visible around campus in casual settings, and posted less to social media.[56]

The strike officially ended five months later in August 25, 2023 when the university agreed to almost all of the strikers' demands, and a 97 percent majority of GEO members ratified the contract.[57]

Israeli–Palestinian conflict

[edit]

On October 10, 2023, Santa Ono condemned "horrific attack by Hamas terrorists".[58] On October 13 afternoon, around 300 University of Michigan students and community members protested outside the President’s House, objecting Ono’s statement and criticizing Ono's ignorance in Palestinian people, casualties, and forced displacement.[59][60] Ono responded with an additional statement on the same day, reaffirming his stance.[61][60] On October 27, he denounced tearing down posters of Israeli hostages hung around the campus.[62] In December, Ono canceled the central student government's voting on two resolutions related to the Israeli–Palestinian conflict.[63][64][65]

On April 30, 2024, United States Representative Virginia Foxx called Santa Ono to a congressional hearing scheduled for May 23 on "antisemitic college chaos".[66][67] On May 21, Ono cited fire safety reasons and sent police to clear the pro-Palestinian encampment on The Diag in front of the Hatcher Graduate Library.[68][69] The encampment was first set up on April 22 to protest for divestment from Israel.[70] Four protestors were arrested.[71] Afterward, the United States House Education and the Workforce Committee changed Ono's congressional testimony format to transcribed interviews instead of having him appear before the full congressional committee as initially expected.[72][73]

Social engagement

[edit]

On January 23, 2017, Ono was appointed chief advisor of the British Columbia Innovation Network and a member of the British Columbia Technology Council.[74] Ono served on the Medical & Scientific Advisory Board of the Tear Film and Ocular Surface Society,[75] as well as on the Medical Advisory Board and College of Experts of the Medical Research Council in the United Kingdom.[76] He has been a member of the Faculty of 1000 since 2003.[77]

Ono speaking at a public event in 2018

Ono wrote articles on research and innovation,[78] college rankings,[79] healthcare,[80] STEM education,[81] diversity,[81] social media,[82] and more.[82] He spoke and wrote about the issue of mental health in adolescents and young adults, advocating for increased funding to identify at-risk youth and support early mental health interventions.[83][84]

Ono received an honorary doctorate degree from Chiba University in Japan in 2016[85] and an honorary doctor of divinity from the Vancouver School of Theology of the University of British Columbia in 2020.[86] In 2017, he received a Professional Achievement Award from the University of Chicago Alumni Association.[87] Ono was elected into the American Academy of Arts & Sciences in 2022.[88] He was elected as fellow of the Canadian Academy of Health Sciences in 2017.[89]

Personal life

[edit]

Santa Ono was named after Santaro, a Japanese folk story character.[90] Ono, a practicing Anglican, is a member of the Anglican Communion Science Commission and has served as a lay Eucharistic minister.[91][92][93]

Ono met Gwendolyn "Wendy" Yip at McGill University in 1985; Yip was in her undergraduate senior year when Ono came to the university to complete his PhD work.[94] The pair married in 1989 and have two daughters together.[95]

Wendy Yip received a Bachelor of Science with a major in immunology from McGill University in 1988 and a Juris Doctor from Boston University in 1991. Her father is Gar Lam Yip (叶嘉林), a Chinese-Canadian professor of electrical and computer engineering at McGill University, and her mother is Alice Chan-Yip (陈敏娜), a Chinese-Canadian pediatrician based in Montreal and former board member with the Montreal Chinese Hospital.[96][94][97][98][99]

References

[edit]
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  2. ^ a b "Regents appoint Santa Ono as University of Michigan's new president | The University Record". record.umich.edu. Archived from the original on July 14, 2022. Retrieved July 13, 2022.
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  4. ^ "Eyelid protein is key to allergy". BBC News. January 16, 2005. Archived from the original on July 14, 2022. Retrieved April 1, 2010.
  5. ^ Ono, Santa Jeremy (March 7, 2023). "Inauguration Address | Office of the President". president.umich.edu. Archived from the original on March 8, 2023. Retrieved March 8, 2023.
  6. ^ "Biography | Office of the President". president.umich.edu. Retrieved October 29, 2024.
  7. ^ Ono, Santa (September 28, 2018). "Brand-building in a Bowtie: A Presidential Perspective" (PDF). The World 100 Reputation Network. p. 2. Archived (PDF) from the original on July 14, 2022. Retrieved July 13, 2022.
  8. ^ "Helen Hay Whitney Foundation - Directory Results". Helen Hay Whitney Foundation. Archived from the original on July 31, 2007.
  9. ^ Ono SJ; Issa-Chergui B; Colle E; Guttmann RD; Seemayer TA; Fuks A (October 1988). "IDDM in BB rats. Enhanced MHC class I heavy-chain gene expression in pancreatic islets". Diabetes. 37 (10): 1411–8. doi:10.2337/diabetes.37.10.1411. PMID 3046971.
  10. ^ Ono SJ; Colle E; Guttmann RD; Fuks A (July 1989). "Interferon-gamma induces transcription and differential expression of MHC genes in rat insulinoma cell line RINm5F". Diabetes. 38 (7): 911–6. doi:10.2337/diabetes.38.7.911. PMID 2544472.
  11. ^ Abdulkadir SA; Ono SJ (November 1995). "How are class II MHC genes turned on and off?". The FASEB Journal. 9 (14): 1429–35. doi:10.1096/fasebj.9.14.7589984. PMID 7589984. S2CID 16604315.
  12. ^ Ono SJ; Song Z (March 1995). "Mapping of the interaction site of the defective transcription factor in the class II major histocompatibility complex mutant cell line clone-13 to the divergent X2-box". The Journal of Biological Chemistry. 270 (11): 6396–402. doi:10.1074/jbc.270.11.6396. PMID 7890777.
  13. ^ Floyd JA; Gold DA; Concepcion D; et al. (November 2003). "A natural allele of Nxf1/TAP suppresses retrovirus insertional mutations". Nature Genetics. 35 (3): 221–8. doi:10.1038/ng1247. PMC 2756099. PMID 14517553.
  14. ^ Arlotta P; Miyazaki D; Copeland NG; Gilbert DJ; Jenkins NA; Ono SJ (June 2002). "Murine NFX.1: isolation and characterization of its messenger RNA, mapping of its chromosomal location and assessment of its developmental expression". Immunology. 106 (2): 173–81. doi:10.1046/j.1365-2567.2002.01416.x. PMC 1782705. PMID 12047746.
  15. ^ Arlotta P; Tai AK; Manfioletti G; Clifford C; Jay G; Ono SJ (May 2000). "Transgenic mice expressing a truncated form of the high mobility group I-C protein develop adiposity and an abnormally high prevalence of lipomas". The Journal of Biological Chemistry. 275 (19): 14394–400. doi:10.1074/jbc.M000564200. PMID 10747931.
  16. ^ Miyazaki D; Nakamura T; Toda M; Cheung-Chau KW; Richardson RM; Ono SJ (February 2005). "Macrophage inflammatory protein–1α as a costimulatory signal for mast cell–mediated immediate hypersensitivity reactions". The Journal of Clinical Investigation. 115 (2): 434–42. doi:10.1172/JCI18452. PMC 544033. PMID 15650768.
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  96. ^ "华人女婿小野三太成密西根大学首位亚裔校长，年薪超650万！_加拿大_美国_因为". www.sohu.com. Archived from the original on October 15, 2022. Retrieved October 12, 2022.
  97. ^ "Gar Lam Yip Memorial Fellowship". Faculty of Engineering. Archived from the original on October 15, 2022. Retrieved October 15, 2022.
  98. ^ General, Office of the Secretary to the Governor. "Ms. Alice Mannor Chan-Yip". The Governor General of Canada. Archived from the original on October 15, 2022. Retrieved October 15, 2022.
  99. ^ "Alice Chan-Yip - McGill University" (PDF). McGill University. October 12, 2018. Archived (PDF) from the original on October 15, 2022. Retrieved October 14, 2022.
[edit]
Academic offices
Preceded by 28th President of the University of Cincinnati
2012–2016 		Succeeded by
Beverly Davenport
(interim)
Preceded by 15th President and Vice-Chancellor
of the University of British Columbia
2016–2022 		Succeeded by
Deborah Buszard
(interim)
Preceded by 15th President of the
University of Michigan
2022–present 		Incumbent
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