Talk:Protein

/Archive 1:October 2003-January 2007==Archived== Since there were no edits to the talk page since January 4 and it was 90+ kbs long, I archived the talk page. Quadzilla99 10:49, 27 January 2007 (UTC)

But the talk page was such an interesting study in the sciences! I understand the issue with the length, but I'd like to advertise here that it's an interesting read if only to see the various cognitive models on display by the posters. 66.93.3.210 04:28, 7 March 2007 (UTC)

Just wanted to point out that moving pic File:Http://upload.wikimedia.org/wikipedia/en/a/ae/Protein Dynamics Cytochrome C 2NEW smaller.gif. it distructs a little when you are trying to read the text.. and i thing i read somewhere some rules what a proper page should/should not contain and i think i didnt recommand animations faster than 1move/3seconds..--91.127.232.51 19:33, 7 November 2007 (UTC)

Importance scale

Incidentally shouldn't this be rated as core on the importance scale? Quadzilla99 10:52, 27 January 2007 (UTC)

What? There's an importance level above 'top'? These assessments are starting to sound like coffee sizes at Starbucks. Opabinia regalis 05:22, 28 January 2007 (UTC)

Maybe I'm wrong I know they have a core group for biographies such as Michael Jordan and others let me check. Quadzilla99 06:20, 28 January 2007 (UTC)

Top is the highest level for these categories. Only biographies have the "core" level that I see. Quadzilla99 23:43, 30 January 2007 (UTC)

Top sounds good to me. Eganio (talk) 23:31, 21 November 2007 (UTC)

where are proteins made?joseph deloria june 20,2007

Proteins are made in the cell's cytoplasm by ribosomes. See the article on translation for more info. Eganio (talk) 23:31, 21 November 2007 (UTC)

Proteins known as antibodies provide protection from disease.

Proteins known as antibodies provide protection from disease.Without proteins, no organism could exist,so proteins are the LAST category of organic molecules to be burned as fuel.Why I thought that first we burn alcohol,then proteins,then carbohydrates,then fat(lipid).What you kids ;) think?--Thank you.MD.Brian (talk) 05:51, 31 January 2008 (UTC)

First we burn sugars/carbohydrates. Next we burn fat. Then we burn protein. We do not burn alcohol for energy, we burn it to detoxify it as a poison. Burning alcohol produces heat as a byproduct. --Agesworth (talk) 09:27, 1 February 2008 (UTC)

Protein

Refer from Buffering agent, which said: "Buffering agents in humans, functioning in acid-base homeostasis, are extracellular agents (e.g., bicarbonate, ammonia) as well as intracellular agents (including proteins and phosphate)." The important thing is, what kind of protein in the cell of human body that work as a buffer? I think this Protein article should be expanded to cover that kind of example... Ivan Akira (talk) 10:21, 16 March 2008 (UTC)

Disambiguation is not a disambiguation

The page has a reference to a disambiguation page, but the disambiguation page is not really a disambiguation page, but merely a list of protein-related topics. Also, I don't see why the link to protein in nutrition is placed under the title. I suggest renaming protein (disambiguation) into "protein-related topics" or similar. Consider making it a category. I would do these myself, but don't know how to do them. CuriousOliver (talk) 12:05, 28 April 2008 (UTC)

The dab page looked fine to me.Asher196 (talk) 13:36, 28 April 2008 (UTC)

Lead picture

The lead picture is a poor choice. A protein is not a cartoon representation of its backbone. The colouring serves no useful purpose for the lead. This picture might be better located at Protein structure, and another image, such as a surface depection, or an all atom model, would be better here. Agesworth 02:44, 28 December 2008 (UTC)

"built from 20 different L-α-amino acids" ?

The line "Proteins are linear polymers built from 20 different L-α-amino acids." sounds a bit misleading. It might suggest that each of the 20 different amino acids needs to be in place, or that there are always exactly 20 amino acids used. So I suggest changing it to "Proteins are linear polymers built from series of up to 20 different L-α-amino acids." JH-man (talk) 15:02, 3 February 2009 (UTC)

Then do it.--Atemperman (talk) 04:57, 5 March 2009 (UTC)

In the shop for repairs

I'll attempt to bring this important article back to GA status. I've got shelves of biochem textbooks at arms length around me, so it shouldn't be too hard to add references for everything and expand the text a bit. Sasata (talk)

VANDALISM: The paragraph on synthesis has been vandalised; april 20, 09 —Preceding unsigned comment added by 84.120.173.238 (talk) 07:08, 20 April 2009 (UTC)

Fixed - thanks for the heads-up. Sasata (talk) 07:33, 20 April 2009 (UTC)

Sentence I don't understand

"The residues in a protein are often chemically modified by post-translational modification, which can happen either before the protein is used in the cell, or as part of control mechanisms"

Maybe it's because of my lack of english, but I don't understand what is meant with this. What are 'control mechanisms'? or does it mean 'as part of the control of mechanisms' ? Kasper90 (talk) 11:27, 21 April 2009 (UTC)

Thanks for the feedback. Have reworded to say: "Shortly after or even during synthesis, the residues in a protein are often chemically modified by post-translational modification, which alter the physical and chemical properties, folding, stability, activity, and ultimately, the function of the proteins." Is that better? Sasata (talk) 17:49, 21 April 2009 (UTC)

Yeah, much better, thank you :)! Kasper90 (talk) 13:18, 22 April 2009 (UTC)

Cellular functions

I think this part of the article is too much about the binding properties of the protein. I think the first paragraph should just summarize all the different functions of proteins in a cell, because that's what you expect to read there. —Preceding unsigned comment added by 115.132.30.240 (talk) 18:13, 23 April 2009 (UTC)

Layman's Overview

The page is so technical that it is largely unapproachable to anyone without a knowledge of chemistry for a word and term that is used in everyday language. A concept as fundamental to nutrition as this should have a leading description that is approachable for those whose education extends to high school, with progressively more detailed content following. —Preceding unsigned comment added by Shatuga (talk • contribs) 12:54, 14 December 2009 (UTC)

Hi, perhaps you were looking for Protein (nutrient)? Graham Colm ^Talk 12:59, 14 December 2009 (UTC)

Confused

This probably isn't that relevant to the page, but in the game Mass Effect 2 they refer to some (alien) species as being either dextro- or levo- protein (or DNA). What does this mean?--86.145.128.26 (talk) 23:03, 18 February 2010 (UTC)

See Amino_acid#Isomerism --Kkmurray (talk) 23:55, 18 February 2010 (UTC)

Someone change this Text in article: Data supports that some protein structures fold into a highly rigid structure Change to: Data supports the conjecture that some protein structures... —Preceding unsigned comment added by 24.108.38.16 (talk) 20:52, 29 September 2010 (UTC)

Maintenance checks

Proteins (also known as polypeptides) are organic compounds gay shit heads amino acids arranged in a linear chain and folded into a globular form. ...

Ironically enough when you Google "Proteins" that ↑ is what comes up on Google, and I'm pretty sure the bold word do not need to be there. I checked over the document and I couldn't find that phrase or anything else inappropriate, but I'm not entirely sure how to remove that from the Google search :/ still hopefully some one can remove that!

If you have any concerns please visit my User-Page (talk) 18:59, 10 November 2010 (UTC)

Yes, it seems Google is currently indexing this vandalised version [1] from the 7 November. This is odd because Google is usually quite quick at updating. Graham Colm (talk) 19:11, 10 November 2010 (UTC)

Length of intro

The lead of this article seems way too long. There are 4 long paragraphs before the table of contents - really this should just be one or two sentences. Someone with more time and knowledge of the subject than me should move some of the text into the main body of the article. Bazonka (talk) 19:38, 15 January 2011 (UTC)

The article length is more than 30,000 characters, and so a four-paragraph lead is perfectly appropriate. See WP:Lead. Sasata (talk) 19:46, 15 January 2011 (UTC)

Adopt an orphan

Monopolin has been an orphan protein since the winter of 2009. "Mono" means "lonely" in Greek... Will spring 2011 bring hope? You can make a difference. ^walk victor falk ^talk 11:14, 10 April 2011 (UTC)

Edit request from Aramirez1, 26 May 2011

Aramirez1 (talk) 18:56, 26 May 2011 (UTC)

This request is empty. You will have to specify what change you would like made to the article. Deli nk (talk) 19:07, 26 May 2011 (UTC)

Peptide Bond

I like the split image approach used in this figure. It's a good way to relate the chemical structure to a pymol-style rendering:










The only catch is that the image on the left clearly highlights the entire amino acid backbone, complete with the alpha carbon and sidechain. Whereas the one on the right specifically circles the peptide bond. This figure implies that the same area is highlighted in both images. I have a few ideas for new figures for this page, I guess I'll start by revising this one. Check back tomorrow to see what I've come up with. I(q) = User(q)·Talk(q) 00:56, 4 September 2011 (UTC)

How about this?

Chemical structure of the peptide bond (bottom) and the three-dimensional structure of a peptide bond between an alanine and an adjacent amino acid (top/inset)

Does something along these lines work? I was mainly going for clarity with this one. I(q) = User(q)·Talk(q) 02:13, 4 September 2011 (UTC)

Oops. I've inadvertently drawn alternating D and L isomers! That's what I get for making a figure late at night!! I(q) = User(q)·Talk(q) 15:02, 4 September 2011 (UTC)

Fixed! I(q) = User(q)·Talk(q) 15:17, 4 September 2011 (UTC)

How about this (below) version? I(q) = User(q)·Talk(q) 14:50, 5 September 2011 (UTC)

Chemical structure of an amide linkage in a protein (bottom) and the three-dimensional structure of an amide linkage between an alanine (R2 = CH3) and an adjacent residue (top/inset)

Class

This article is about a class of molecules. Is this a colloquial expression or are proteins really "an official class" of compounds. If yes: Where can I find a written statement of that? Thanx Grey Geezer 15:37, 26 November 2011 (UTC) — Preceding unsigned comment added by Grey Geezer (talk • contribs)

wow

i dont understand one word on that page. whoever wrote that is a geinus, but dumb it down please, for the morons (me). Jake1993811 (talk) 06:18, 31 December 2011 (UTC)

Try WP/Simple hydnjo (talk) 15:52, 31 December 2011 (UTC)

Edit request on 6 March 2012

• Structural Biology Knowledgebase: annotations for every known protein molecular structure.

Shahraship (talk) 19:50, 6 March 2012 (UTC)

 Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate. --Redrose64 (talk) 19:54, 6 March 2012 (UTC)