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Evolution of the eye

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Major stages in the evolution of the mollusc eye.

The evolution of the eye has been a subject of significant study, as a distinctive example of a homologous organ present in a wide variety of taxa. Certain components of the eye, such as the visual pigments, appear to have a common ancestry: that is, they evolved once, before the animals radiated. However, complex, image-forming eyes evolved some 50 to 100 times[1] – using many of the same proteins and genetic toolkits in their construction.[2][3]

Complex eyes appear to have first evolved within a few million years, in the rapid burst of evolution known as the Cambrian explosion. There is no evidence of eyes before the Cambrian, but a wide range of diversity is evident in the Middle Cambrian Burgess shale, and the slightly older Emu Bay Shale.[4] Eyes show a wide range of adaptations to meet the requirements of the organisms which bear them. Eyes vary in their visual acuity, the range of wavelengths they can detect, their sensitivity in low light levels, their ability to detect motion or resolve objects, and whether they can discriminate colours.

History of research

The human eye, demonstrating the iris

The complex structure of the eye has been argued to be evidence in support the idea that it was designed by a creator, as it was claimed to be an example of irreducible complexity, impossible to have evolved via natural selection. In 1802, philosopher William Paley called it a miracle of "design". Charles Darwin himself wrote in his Origin of Species, that the evolution of the eye by natural selection at first glance seemed "absurd in the highest possible degree". However, he went on to explain that despite the difficulty in imagining it, this was perfectly feasible:

...if numerous gradations from a simple and imperfect eye to one complex and perfect

can be shown to exist, each grade being useful to its possessor, as is certainly the case; if further, the eye ever varies and the variations be inherited, as is likewise certainly the case and if such variations should be useful to any animal under changing conditions of life, then the difficulty of believing that a perfect and complex eye could be formed by natural selection,

though insuperable by our imagination, should not be considered as subversive of the theory.[5]

He suggested a gradation from "an optic nerve merely coated with pigment, and without any other mechanism" to "a moderately high stage of perfection", giving examples of extant intermediate grades of evolution.[5] Darwin's suggestions were soon shown to be correct, and current research is investigating the genetic mechanisms responsible for eye development and evolution.[6]

Rate of evolution

The first fossils of eyes that have been found to date are from the lower Cambrian period (about 540 million years ago).[7] This period saw a burst of apparently rapid evolution, dubbed the "Cambrian explosion". One of the many hypotheses for "causes" of this diversification, the "Light Switch" theory of Andrew Parker, holds that the evolution of eyes initiated an arms race that led to a rapid spate of evolution.[8] Earlier than this, organisms may have had use for light sensitivity, but not for fast locomotion and navigation by vision.

Since the fossil record, particularly of the Early Cambrian, is so poor, it is difficult to estimate the rate of eye evolution. Simple modelling, invoking small mutations exposed to natural selection, demonstrates that a primitive optical sense organ based upon efficient photopigments could evolve into a complex human-like eye in approximately 400,000 years.[9][note 1]

One origin or many?

Whether one considers the eye to have evolved once or multiple times depends somewhat on the definition of an eye. Much of the genetic machinery employed in eye development is common to all eyed organisms, which may suggest that their ancestor utilized some form of light-sensitive machinery – even if it lacked a dedicated optical organ. However, even photoreceptor cells may have evolved more than once from molecularly similar chemoreceptors, and photosensitive cells probably existed long before the Cambrian explosion.[10] Higher-level similarities – such as the use of the protein crystallin in the independently derived cephalopod and vertebrate lenses[11] – reflect the co-option of a protein from a more fundamental role to a new function within the eye.[12]

Shared traits common to all light-sensitive organs include the family of photo-receptive proteins called opsins. All seven sub-families of opsin were already present in the last common ancestor of animals. In addition, the genetic toolkit for positioning eyes is common to all animals: the PAX6 gene controls where the eye develops in organisms ranging from mice to humans to fruit flies.[13][14][15] These high-level genes are, by implication, much older than many of the structures that they are today seen to control; they must originally have served a different purpose, before being co-opted for a new role in eye development.[12]

Sensory organs probably evolved before the brain did—there is no need for an information-processing organ (brain) before there is information to process.[16]

Stages of eye evolution

The stigma (2) of the euglena hides a light-sensitive spot.

The earliest predecessors of the eye were photoreceptor proteins that sense light, found even in unicellular organisms, called "eyespots". Eyespots can only sense ambient brightness: they can distinguish light from dark, sufficient for photoperiodism and daily synchronization of circadian rhythms. They are insufficient for vision, as they cannot distinguish shapes or determine the direction light is coming from. Eyespots are found in nearly all major animal groups, and are common among unicellular organisms, including euglena. The euglena's eyespot, called a stigma, is located at its anterior end. It is a small splotch of red pigment which shades a collection of light sensitive crystals. Together with the leading flagellum, the eyespot allows the organism to move in response to light, often toward the light to assist in photosynthesis,[17] and to predict day and night, the primary function of circadian rhythms. Visual pigments are located in the brains of more complex organisms, and are thought to have a role in synchronising spawning with lunar cycles. By detecting the subtle changes in night-time illumination, organisms could synchronise the release of sperm and eggs to maximise the probability of fertilisation.[citation needed]

Vision itself relies on a basic biochemistry which is common to all eyes. However, how this biochemical toolkit is used to interpret an organism's environment varies widely: eyes have a wide range of structures and forms, all of which have evolved quite late relative to the underlying proteins and molecules.[17]

At a cellular level, there appear to be two main "designs" of eyes, one possessed by the protostomes (molluscs, annelid worms and arthropods), the other by the deuterostomes (chordates and echinoderms).[17]

The functional unit of the eye is the receptor cell, which contains the opsin proteins and responds to light by initiating a nerve impulse. The light sensitive opsins are borne on a hairy layer, to maximise the surface area. The nature of these "hairs" differs, with two basic forms underlying photoreceptor structure: microvilli and cilia.[18] In the protostomes, they are microvilli: extensions or protrusions of the cellular membrane. But in the deuterostomes, they are derived from cilia, which are separate structures.[17] The actual derivation may be more complicated, as some microvilli contain traces of cilia — but other observations appear to support a fundamental difference between protostomes and deuterostomes.[17] These considerations centre on the response of the cells to light – some use sodium to cause the electric signal that will form a nerve impulse, and others use potassium; further, protostomes on the whole construct a signal by allowing more sodium to pass through their cell walls, whereas deuterostomes allow less through.[17]

This suggests that when the two lineages diverged in the Precambrian, they had only very primitive light receptors, which developed into more complex eyes independently.

Early eyes

The basic light-processing unit of eyes is the photoreceptor cell, a specialized cell containing two types of molecules in a membrane: the opsin, a light-sensitive protein, surrounding the chromophore, a pigment that distinguishes colors. Groups of such cells are termed "eyespots", and have evolved independently somewhere between 40 and 65 times. These eyespots permit animals to gain only a very basic sense of the direction and intensity of light, but not enough to discriminate an object from its surroundings.[17]

Developing an optical system that can discriminate the direction of light to within a few degrees is apparently much more difficult, and only six of the thirty-something phyla[note 2] possess such a system. However, these phyla account for 96% of living species.[17]

The planarian has "cup" eyespots that can slightly distinguish light direction.

These complex optical systems started out as the multicellular eyepatch gradually depressed into a cup, which first granted the ability to discriminate brightness in directions, then in finer and finer directions as the pit deepened. While flat eyepatches were ineffective at determining the direction of light, as a beam of light would activate exactly the same patch of photo-sensitive cells regardless of its direction, the "cup" shape of the pit eyes allowed limited directional differentiation by changing which cells the lights would hit depending upon the light's angle. Pit eyes, which had arisen by the Cambrian period, were seen in ancient snails,[clarification needed] and are found in some snails and other invertebrates living today, such as planaria. Planaria can slightly differentiate the direction and intensity of light because of their cup-shaped, heavily-pigmented retina cells, which shield the light-sensitive cells from exposure in all directions except for the single opening for the light. However, this proto-eye is still much more useful for detecting the absence or presence of light than its direction; this gradually changes as the eye's pit deepens and the number of photoreceptive cells grows, allowing for increasingly precise visual information.[19]

When a photon is absorbed by the chromophore, a chemical reaction causes the photon's energy to be transduced into electrical energy and relayed, in higher animals, to the nervous system. These photoreceptor cells form part of the retina, a thin layer of cells that relays visual information,[20] including the light and day-length information needed by the circadian rhythm system, to the brain. However, some jellyfish, such as Cladonema, have elaborate eyes but no brain. Their eyes transmit a message directly to the muscles without the intermediate processing provided by a brain.[16]

During the Cambrian explosion, the development of the eye accelerated rapidly, with radical improvements in image-processing and detection of light direction.[21]

The primitive nautilus eye functions similarly to a pinhole camera.

The "pinhole camera" eye was developed as the pit deepened into a cup, then a chamber. By reducing the size of the opening, the organism achieved true imaging, allowing for fine directional sensing and even some shape-sensing. Eyes of this nature are currently found in the nautilus. Lacking a cornea or lens, they provide poor resolution and dim imaging, but are still, for the purpose of vision, a major improvement over the early eyepatches.[22]

Overgrowths of transparent cells prevented contamination and parasitic infestation. The chamber contents, now segregated, could slowly specialize into a transparent humour, for optimizations such as colour filtering, higher refractive index, blocking of ultraviolet radiation, or the ability to operate in and out of water. The layer may, in certain classes[which?], be related to the moulting of the organism's shell or skin.

It is likely that a key reason eyes specialize in detecting a specific, narrow range of wavelengths on the electromagnetic spectrum—the visible spectrum—is because the earliest species to develop photosensitivity were aquatic, and only two specific wavelength ranges of electromagnetic radiation, blue and green visible light, can travel through water. This same light-filtering property of water also influenced the photosensitivity of plants.[23][24][25]

Lens formation and diversification

Light from a distant object and a near object being focused by changing the curvature of the lens

Lenses evolved independently in a number of lineages. Simple 'pit-eyes' probably developed lenses to improve the amount of light that reached the retina; the focal length of an early lobopod with lens-containing simple eyes focused the image behind the retina, so while no part of the image could be brought into focus, the intensity of light allowed the organism to see in deeper (and therefore darker) waters.[26] A subsequent increase of the lens's refractive index probably resulted in an in-focus image being formed.[26]

The development of the lens in camera-type eyes probably followed a different trajectory. The transparent cells over a pinhole eye's aperture split into two layers, with liquid in between.[citation needed] The liquid originally served as a circulatory fluid for oxygen, nutrients, wastes, and immune functions, allowing greater total thickness and higher mechanical protection. In addition, multiple interfaces between solids and liquids increase optical power, allowing wider viewing angles and greater imaging resolution. Again, the division of layers may have originated with the shedding of skin; intracellular fluid may infill naturally depending on layer depth.[citation needed]

Note that this optical layout has not been found, nor is it expected to be found. Fossilization rarely preserves soft tissues, and even if it did, the new humour would almost certainly close as the remains desiccated, or as sediment overburden forced the layers together, making the fossilized eye resemble the previous layout.

Compound eye of Antarctic krill

Vertebrate lenses are composed of adapted epithelial cells which have high concentrations of the protein crystallin. In the embryo, the lens is living tissue, but the cellular machinery is not transparent so must be removed before the organism can see. Removing the machinery means the lens is composed of dead cells, packed with crystallins which must last the life of the organism. The refractive index gradient which makes the lens useful is caused by the radial shift in crystallin concentration in different parts of the lens, rather than by the specific type of protein: it is not the presence of crystallin, but the relative distribution of it, that renders the lens useful.[27]

It is biologically difficult to maintain a transparent layer of cells. Deposition of transparent, nonliving, material eased the need for nutrient supply and waste removal. Trilobites used calcite, a mineral which has not been used by any other organism; in other compound eyes[verification needed] and camera eyes, the material is crystallin. A gap between tissue layers naturally forms a biconvex shape, which is optically and mechanically ideal for substances of normal refractive index. A biconvex lens confers not only optical resolution, but aperture and low-light ability, as resolution is now decoupled from hole size—which slowly increases again, free from the circulatory constraints.

Independently, a transparent layer and a nontransparent layer may split forward from the lens: a separate cornea and iris. (These may happen before or after crystal deposition, or not at all.) Separation of the forward layer again forms a humour, the aqueous humour. This increases refractive power and again eases circulatory problems. Formation of a nontransparent ring allows more blood vessels, more circulation, and larger eye sizes. This flap around the perimeter of the lens also masks optical imperfections, which are more common at lens edges. The need to mask lens imperfections gradually increases with lens curvature and power, overall lens and eye size, and the resolution and aperture needs of the organism, driven by hunting or survival requirements. This type is now functionally identical to the eye of most vertebrates, including humans. Indeed, "the basic pattern of all vertebrate eyes is similar."[28]

Other developments

Color vision

The ability to see colors presents distinct selective advantages for species, such as being better able to recognize predators, food, and mates. Indeed, it is thought that simple sensory-neural mechanisms may selectively control general behaviour patterns, such as escape, foraging, and hiding. Many examples of wavelength-specific behaviour patterns have been identified, in two primary groups: less than 450 nm, associated with natural light sources, and greater than 450 nm, associated with reflected light sources.[29] As opsin molecules were subtly fine-tuned to detect different wavelengths of light, at some point color vision developed when photoreceptor cells developed multiple pigments.[20] As a chemical adaption rather than a mechanical one, this may have occurred at any of the early stages of the eye's evolution, and the capability may have disappeared and reappeared as organisms became predator or prey. Similarly, night and day vision emerged when receptors differentiated into rods and cones, respectively.

Further information: Evolution of color vision

Focusing mechanism

Some species move the lens back and forth, some stretch the lens flatter. Another mechanism regulates focusing chemically and independently of these two, by controlling growth of the eye and maintaining focal length. Note that a focusing method is not a requirement. As photographers know, focal errors increase as aperture increases. Thus, countless organisms with small eyes are active in direct sunlight and survive with no focus mechanism at all. As a species grows larger, or transitions to dimmer environments, a means of focusing need only appear gradually.

Location

Prey generally have eyes on the sides of their head so to have a larger field of view, from which to avoid predators. Predators, however, have eyes in front of their head in order to have better depth perception.[30][31] Flatfish are predators which lie on their side on the bottom, and have eyes placed asymmetrically on the same side of the head. A transitional fossil from the common symmetric position is Amphistium.

Evolutionary baggage

Vertebrates and octopuses developed the camera eye independently. In the vertebrate version the nerve fibers pass in front of the retina, and there is a blind spot where the nerves pass through the retina. In the vertebrate example, 4 represents the blind spot, which is notably absent from the octopus eye. In vertebrates, 1 represents the retina and 2 is the nerve fibers, including the optic nerve (3), whereas in the octopus eye, 1 and 2 represent the nerve fibers and retina respectively.
Main article: Evolutionary baggage

The eyes of many taxa record their evolutionary history in their contemporary anatomy. The vertebrate eye, for instance, is built "backwards and upside down", requiring "photons of light to travel through the cornea, lens, aqueous fluid, blood vessels, ganglion cells, amacrine cells, horizontal cells, and bipolar cells before they reach the light-sensitive rods and cones that transduce the light signal into neural impulses, which are then sent to the visual cortex at the back of the brain for processing into meaningful patterns."[32] While such construct seems to have drawbacks, it allows the outer retina of the vertebrates to sustain higher metabolic activities as compared to the non-inverted design.[33] It also allowed for the evolution of the choroid layer, including the retinal pigment epithelial (RPE) cells, which play an important role in protecting the photoreceptive cells from photo-oxidative damage.[34] [35]

The camera eyes of cephalopods, in contrast, are constructed the "right way out", with the nerves attached to the rear of the retina. This means that they do not have a blind spot. This difference may be accounted for by the origins of eyes; in cephalopods they develop as an invagination of the head surface whereas in vertebrates they originate as an extension of the brain.

Footnotes

  1. ^ David Berlinski, an intelligent design proponent, questioned the basis of the calculations, and the author of the original paper {{subst:wict|refute}}d Berlinski's criticism.
    • Berlinski, David (2001). "Commentary magazine". {{cite journal}}: Cite journal requires |journal= (help); Unknown parameter |month= ignored (help)
  2. ^ The precise number varies from author to author.

References

  1. ^ Haszprunar (1995). "The mollusca: Coelomate turbellarians or mesenchymate annelids?". In Taylor (ed.). Origin and evolutionary radiation of the Mollusca : centenary symposium of the Malacological Society of London. Oxford: Oxford Univ. Press. ISBN 0-19-854980-6.
  2. ^ Kozmik, Z; Daube, Michael; Frei, Erich; Norman, Barbara; Kos, Lidia; Dishaw, Larry J.; Noll, Markus; Piatigorsky, Joram (2003). "Role of Pax Genes in Eye Evolution A Cnidarian PaxB Gene Uniting Pax2 and Pax6 Functions". Developmental Cell. 5 (5): 773–785. doi:10.1016/S1534-5807(03)00325-3. PMID 14602077.
  3. ^ Land, M.F. and Nilsson, D.-E., Animal Eyes, Oxford University Press, Oxford (2002).
  4. ^ Lee M.S.Y., Jago, J.B., Garcia-Bellido, D.C., Edgecombe, G.E., Gehling, J.G, Paterson, J.R. 2011. Modern optics in exceptionally preserved eyes of Early Cambrian arthropods from Australia. Nature 474: 631-634
  5. ^ a b Darwin, Charles (1859). On the Origin of Species. London: John Murray.
  6. ^ Gehring WJ (2005). "New perspectives on eye development and the evolution of eyes and photoreceptors". J. Hered. 96 (3): 171–84. doi:10.1093/jhered/esi027. PMID 15653558.
  7. ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1016/j.optlastec.2008.12.020, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1016/j.optlastec.2008.12.020 instead.
  8. ^ Parker, Andrew (2003). In the Blink of an Eye: How Vision Sparked the Big Bang of Evolution. Cambridge, MA: Perseus Pub. ISBN 0-7382-0607-5.
  9. ^ Nilsson, D-E; Pelger S (1994). "A pessimistic estimate of the time required for an eye to evolve". Proc R Soc Lond B. 256 (1345): 53–58. doi:10.1098/rspb.1994.0048. PMID 8008757.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  10. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 8805210, please use {{cite journal}} with |pmid= 8805210 instead.
  11. ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1016/S0167-4838(99)00066-7 , please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1016/S0167-4838(99)00066-7 instead.
  12. ^ a b Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 20394064, please use {{cite journal}} with |pmid=20394064 instead.
  13. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 8664548, please use {{cite journal}} with |pmid=8664548 instead.
  14. ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1126/science.7892602, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1126/science.7892602 instead.
  15. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 9122210, please use {{cite journal}} with |pmid=9122210 instead.
  16. ^ a b Gehring, W. J. (13 January 2005). "New Perspectives on Eye Development and the Evolution of Eyes and Photoreceptors" (Full text). Journal of Heredity. 96 (3). Oxford Journals: 171–184. doi:10.1093/jhered/esi027. PMID 15653558. Retrieved 26 April 2008.
  17. ^ a b c d e f g h M F Land; R D Fernald (1992). "The Evolution of Eyes". Annual Review of Neuroscience. 15: 1–29. doi:10.1146/annurev.ne.15.030192.000245. PMID 1575438.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  18. ^ Autrum, H (1979). "Introduction". In H. Autrum (editor) (ed.). Comparative Physiology and Evolution of Vision in Invertebrates- A: Invertebrate Photoreceptors. Handbook of Sensory Physiology. Vol. VII/6A. New York: Springer-Verlag. pp. 6–9. ISBN 3-540-08837-7. {{cite book}}: |editor= has generic name (help)
  19. ^ Eye-Evolution?
  20. ^ a b Fernald, Russell D. (2001). The Evolution of Eyes: How Do Eyes Capture Photons? Karger Gazette 64: "The Eye in Focus".
  21. ^ Conway-Morris, S. (1998). The Crucible of Creation. Oxford: Oxford University Press.
  22. ^ Dawkins, Richard (1986). The Blind Watchmaker.
  23. ^ Fernald, Russell D. (2001). The Evolution of Eyes: Why Do We See What We See? Karger Gazette 64: "The Eye in Focus".
  24. ^ Fernald, Russell D. (1998). Aquatic Adaptations in Fish Eyes. New York, Springer.
  25. ^ Fernald RD (1997). "The evolution of eyes". Brain Behav. Evol. 50 (4): 253–9. doi:10.1159/000113339. PMID 9310200.
  26. ^ a b Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1111/j.1502-3931.2008.00138.x, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1111/j.1502-3931.2008.00138.x instead.
  27. ^ Fernald, Russell D. (2001). The Evolution of Eyes: Where Do Lenses Come From? Karger Gazette 64: "The Eye in Focus".
  28. ^ Ali, Mohamed Ather; Klyne, M.A. (1985). Vision in Vertebrates. New York: Plenum Press. p. 1. ISBN 0-306-42065-1.
  29. ^ Menzel, Randolf (1979). "Spectral Sensitivity and Color Vision in Invertebrates". In H. Autrum (editor) (ed.). Comparative Physiology and Evolution of Vision in Invertebrates- A: Invertebrate Photoreceptors. Handbook of Sensory Physiology. Vol. VII/6A. New York: Springer-Verlag. pp. 504–506, 551–558. ISBN 3-540-08837-7. {{cite book}}: |editor= has generic name (help)
  30. ^ "Carnivores". U.S. Department of the Interior, Bureau of Land Management. 14 December 2009. Retrieved 28 March 2011.
  31. ^ Boroditsky, Lera (6/24/99). "Light & Eyes: Lecture Notes". Lecture Notes. Stanford. Retrieved 11 May 2010. {{cite web}}: Check date values in: |date= (help)
  32. ^ Dr. Michael Shermer, as quoted by Christopher Hitchens in his book "God is Not Great" (pg.82)
  33. ^ Reichenbach A, Bringmann A. (2010). Müller cells in the healthy and diseased retina. New York: Springer. pp 15 - 20.
  34. ^ http://www.photobiology.info/Rozanowska.html
  35. ^ Diagrammatic representation of disc shedding and phagosome retrieval into the pigment epithelial cell.[1]

Further reading

  • Land, M. F., & Nilsson, D-E, Animal Eyes, Oxford: Oxford University Press, 2002 ISBN 0-19-850968-5 "The origin of vision", Chapter 1, pages 1–15
  • Ivan R. Schwab (2012). Evolution's Witness: How Eyes Evolved. New York: Oxford University Press. ISBN 9780195369748.
  • Myers, PZ (21 December 2007). "Evolution of vertebrate eyes". Pharyngula. ScienceBlogs. Retrieved 23 December 2007. a review of Lamb TD, Collin SP, Pugh EN Jr. (2007) Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nat Rev Neurosci 8(12):960-76.

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