(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase

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3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase
4ylh.jpg
3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase hexamer, Streptomyces toyocaensis
Identifiers
EC number1.13.11.80
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase (EC 1.13.11.80, DpgC is an enzyme [1] catalyses the following chemical reaction

(3,5-dihydroxyphenyl)acetyl-CoA + O2 ⇌ 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA.

This enzyme is involved in the biosynthesis of the nonproteinogenic amino acid (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. It catalyzes the unusual conversion 3,5-dihydroxyphenylacetyl-CoA (DPA-CoA) to 3,5-dihydroxyphenylglyoxylate.

References[edit]

  1. ^ Fielding, E.N.; Widboom, P.F.; Bruner, S.D. (2007). "Substrate recognition and catalysis by the cofactor-independent dioxygenase DpgC". Biochemistry. 46 (49): 13994–14000. doi:10.1021/bi701148b. PMID 18004875.