|PDB structures||RCSB PDB PDBe PDBsum|
(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase (EC 184.108.40.206, DpgC) is an enzyme catalyses the following chemical reaction
- (3,5-dihydroxyphenyl)acetyl-CoA + O2 ⇌ 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA.
This enzyme is involved in the biosynthesis of the nonproteinogenic amino acid (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. It catalyzes the unusual conversion 3,5-dihydroxyphenylacetyl-CoA (DPA-CoA) to 3,5-dihydroxyphenylglyoxylate.
- ^ Fielding EN, Widboom PF, Bruner SD (December 2007). "Substrate recognition and catalysis by the cofactor-independent dioxygenase DpgC". Biochemistry. 46 (49): 13994–4000. doi:10.1021/bi701148b. PMID 18004875.