The prologue was a 1.15 km (0.71 mi) individual time trial. It was won by the AustralianBrett Lancaster with a 0.289 second advantage over Matteo Tosatto, who scored second. After the last rider, Mario Cipollini received the homage of the Italian cycling world, doing the 1.15 kilometer race out of competition. He had announced his retirement just ten days before.
At the beginning of the first stage, a four-man breakaway formed and led by almost ten minutes at one point. Thorwald Veneberg was finally captured again about 20 kilometers before the end. However, his efforts paid by giving him the first maglia Verde of the Giro. On the last kilometer Paolo Bettini managed to get away on a very steep gradient.
Having been defeated by Paolo Bettini and Robbie McEwen on the previous stage, Italian favorite Alessandro Petacchi failed yet again in the bunch sprint in Santa Maria Del Cedro. This time, he claimed, he had been forced to change his direction because of EstonianJaan Kirsipuu.
Just as in the first stage, the sprinter's teams were not able to stop a breakaway in the last kilometers of the race. This time, it was a group of fifty riders which included all the GC important riders. Danilo DI Luca, in a great form in season 2005, beat fellow Italian Damiano Cunego in the sprint for the stage victory.
Paolo Bettini won the sprint at the end which was fought between five cyclists. But in this process he caused Baden Cooke to fall and was declassified because of this. Luca Mazzanti, who came in second, inherited the victory. After the stage, Bettini threatened to abandon the race, but it turned out to be an empty threat.
Danilo DI Luca got his second stage victory in 2005 Giro d'Italia, notching this win ahead of Fassa Bortolo's Marzio Bruseghin. Otherwise, this stage had no important influence on the fight for General Classification.
Just as Danilo DI Luca had done the previous day, AustralianRobbie McEwen took his second win in this year's Giro. This time, he did not have to beat Alessandro Petacchi, since the Italian's Torino biancoblù de-railed, causing the fall of some of the Fassa Bortolo riders, and forcing "Ale-Jet" to halt to a stop. McEwen's teammate Henk Vogels attacked in the last kilometer, but was surpassed just at the finish line by up to four other cyclists.
After a long breakaway, lasting throughout most of the stage, Spaniard Koldo Gil was the first to arrive at the finish line in Pistoia. Damiano Cunego, who was second, leading a pursuing group, celebrated thinking he had won the stage, not knowing that Gil had already taken the victory. Ivan Basso, who had been forced to change his bicycle because of a puncture in the last climb of the day, lost thirty seconds to his rivals for GC.
The eighth stage was a time trial. Danilo DI Luca came in tenth and was able to keep the Maglia Rosa. Otherwise, this stage meant the victory for AmericanDavid Zabriskie, and the revival of his teammate Ivan Basso, second in the time trial, and who made up for all the time he had lost the day before and even more. On the other hand, this was a very bad day for both Lampre riders Damiano Cunego and Gilberto Simoni.
On the stage after the race's first rest day, Robbie McEwen took vengeance on Alessandro Petacchi in a bunch sprint. The bunch spring had to be solved with the aid of the photo-finish, which determined that the Australian had beaten the Italian by a mere question of millimeters.
