The ceremony for the 22nd Hong Kong Film Awards was held on 6 April 2003 in the Hong Kong Cultural Centre and hosted by Eric Tsang, John Shum, Athena Chu and Anna Yau. Twenty-seven winners in nineteen categories were unveiled. The year's biggest winner turned out to be Infernal Affairs, which won seven awards, including Best Film, Best Director, Best Screenplay, Best Actor, Best Supporting Actor, Best Film Editing and Best Original Film Song. Besides the eighteen regular awards, the 22nd Hong Kong Film Awards also presented veteran actors Cho Tat Wah and Shek Kin with the Professional Achievement Award.
The ceremony also paid tribute to the local health care workers battling the SARS virus, which hit Hong Kong on 11 March 2003 and would eventually claim 299 deaths there within the subsequent three months. Some present at the ceremony were seen wearing surgical masks to prevent against infection.