|Centuries:||6th century – 7th century – 8th century|
|Decades:||610s 620s 630s – 640s – 650s 660s 670s|
|Years:||638 639 640 – 641 – 642 643 644|
|641 by topic|
|State leaders – Sovereign states|
|Birth and death categories|
|Births – Deaths|
|Establishment and disestablishment categories|
|Establishments – Disestablishments|
|Ab urbe condita||1394|
|Chinese calendar||庚子年 (Metal Rat)
3337 or 3277
— to —
辛丑年 (Metal Ox)
3338 or 3278
|- Vikram Samvat||697–698|
|- Shaka Samvat||563–564|
|- Kali Yuga||3742–3743|
|Minguo calendar||1271 before ROC
|Seleucid era||952/953 AG|
|Thai solar calendar||1183–1184|
Year 641 (DCXLI) was a common year starting on Monday (link will display the full calendar) of the Julian calendar. The denomination 641 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years.
- February 11 – Emperor Heraclius, age 65, dies of dropsy at Constantinople after a 31-year reign. He has reorganized the imperial administration but lost Armenia, Egypt, Palestine, Syria and much of Mesopotamia to the Muslim Arabs. Heraclius is succeeded by his sons Constantine III and Heraklonas.
- May – Constantine III, age 29, dies of tuberculosis after a four-month reign, leaving his half-brother Heraklonas sole emperor. Rumors spread that Constantine has been poisoned by Heraclius's second wife (and niece) Martina.
- September – The Byzantine Senate turn against Martina and her son Heraklonas, who are both multilated and exiled to Rhodes. Supported by general Valentinus, Constantine's son Constans II, age 10, succeeds to the throne.
- Constans II establishes a new civil-military defensive organisation based upon geographical military district. Byzantine forces maintain the frontier along the line of the Taurus Mountains (Southern Turkey).
- Aega, Mayor of the Palace and regent, alongside of queen mother Nanthild of Neustria and Burgundy, dies during the reign of king Clovis II. He is replaced by Erchinoald, a relative of Dagobert I's mother.
- The Lombards under king Rothari conquer Genoa (Liguria) and all remaining Byzantine territories in the lower Po Valley, including Oderzo (Opitergium).
- Arechis I, duke of Benevento (northeast of Naples), dies after a 50-year reign and is succeeded by his son Aiulf I.
- Prince Oswiu of Bernicia conquers Gododdin or "The Old North" as far north as Manau (modern Scotland), on behalf of his half-brother, king Oswald (approximate date).
- King Bridei II dies after a 5-year reign and is succeeded by his brother Talorc III as ruler of the Picts.
- November 8 – Siege of Alexandria: Muslim Arabs under 'Amr ibn al-'As capture Alexandria after a fourteen-month siege. Byzantine officials formally capitulate to Amr, turning the city over to Arab hands.
- The city of Fustat (later Cairo) is founded in Egypt. It becomes the first capital of Egypt under muslim rule.
- Emperor Taizong of the Tang dynasty (China) instigates a civil war in the Western Turkic Khaganate by supporting Isbara Yabghu Qaghan.
- November 17 – Emperor Jomei of Japan, age 48, dies after a 12-year reign.
- Aega, Mayor of the Palace (Neustria and Burgundy)
- Arechis I, duke of Benevento (Italy)
- Bridei II, king of the Picts
- Constantine III, emperor of the Byzantine Empire
- February 11 – Heraclius, Byzantine emperor
- November 17 – Jomei, emperor of Japan (b. 593)
- Mu, king of Baekje (one of the Three Kingdoms of Korea)
- Ouyang Xun, Confucian scholar and calligrapher (b. 557)
- Zaynab bint Jahsh, wife of Muhammad