Flavonolignan
Flavonolignans are natural phenols composed of a part flavonoid and a part phenylpropane.
Examples
Flavonolignans identified in Silybum marianum (milk thistle) silymarin complex include silibinin, silychristin, silydianin, dehydrosilybin, deoxysilycistin, deoxysilydianin, silandrin, silybinome, silyhermin and neosilyhermin and can be produced in vitro.[1] Silibinin is found in the roots of S. marianum[2] while silyamandin[3] can be found in the fruit.[4]
Hydnocarpin can be found naturally in Onopordon corymbosum[5] and can be synthesised.[6]
Scutellaprostin A, B, C, D, E and F can be isolated from Scutellaria prostrata and can also be synthesized.[7]
Hydnowightin can be isolated from Hydnocarpus wightiana seeds.[8]
Three flavonolignans derived from the flavone tricin have been isolated from the herb Avena sativa.[9]
Palstatin has been isolated from the Amazon tree Hymeneae palustris.[10]
Salcolin A and salcolin B can be found in Salsola collina.[11]
Rhodiolin, the product of the oxidative coupling of coniferyl alcohol with the 7,8-dihydroxy grouping of the flavonol herbacetin, can be found in the rhizome of Rhodiola rosea.[12]
Glycosides
The flavonolignans tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether and tricin 4'-O-(threo-beta-guaiacylglyceryl) ether can be isolated together with their 7-O-glucosides in the leaves of Hyparrhenia hirta.[13]
Research
A 2022 research has concluded that flavonolignans "reduce the virulence of antibiotic-resistant bacterial strains".[14]
References
- ^ Tůmová L, Řimáková J, Tůma J, Dušek J (2006). "Silybum marianum in vitro-flavonolignan production" (PDF). Plant, Soil and Environment. 52 (10): 454–8. doi:10.17221/3466-PSE. Archived from the original (PDF) on 2011-07-18.
- ^ Alikaridis F, Papadakis D, Pantelia K, Kephalas T (August 2000). "Flavonolignan production from Silybum marianum transformed and untransformed root cultures". Fitoterapia. 71 (4): 379–84. doi:10.1016/S0367-326X(00)00134-9. PMID 10925007.
- ^ Sarris, Jerome; Seaton, Kylie (2007). "Silyamandin: A New Flavonolignan". Australian Journal of Medical Herbalism. 19 (4): 187.
- ^ MacKinnon SL, Hodder M, Craft C, Simmons-Boyce J (September 2007). "Silyamandin, a new flavonolignan isolated from milk thistle tinctures". Planta Medica. 73 (11): 1214–6. doi:10.1055/s-2007-981595. PMID 17823870.
- ^ Cardona, M; Garcia, B; Pedro, J; Sinisterra, J (1990). "Flavonoids, flavonolignans and a phenylpropanoid from Onopordon corymbosum". Phytochemistry. 29 (2): 629. doi:10.1016/0031-9422(90)85131-X.
- ^ Guz NR, Stermitz FR (August 2000). "Synthesis and structures of regioisomeric hydnocarpin-type flavonolignans". Journal of Natural Products. 63 (8): 1140–5. doi:10.1021/np000166d. PMID 10978213.
- ^ Kikuchi Y, Miyaichi Y, Tomimori T (August 1991). "[Total synthesis of flavonolignans, scutellaprostins A, B, C, D, E and F]". Yakugaku Zasshi (in Japanese). 111 (8): 424–35. doi:10.1248/yakushi1947.111.8_424. PMID 1665511.
- ^ CID 6438705 from PubChem
- ^ Wenzig, Eva; Kunert, Olaf; Ferreira, Daneel; Schmid, Martin; Schühly, Wolfgang; Bauer, Rudolf; Hiermann, Alois (2005). "Flavonolignans fromAvenasativa". Journal of Natural Products. 68 (2): 289–92. doi:10.1021/np049636k. PMID 15730266.
- ^ Pettit, George R.; Meng, Yanhui; Stevenson, Clare A.; Doubek, Dennis L.; Knight, John C.; Cichacz, Zbigniew; Pettit, Robin K.; Chapuis, Jean-Charles; Schmidt, Jean M. (2003). "Isolation and Structure of Palstatin from the Amazon TreeHymeneaepalustris1". Journal of Natural Products. 66 (2): 259–62. doi:10.1021/np020231e. PMID 12608861.
- ^ Syrchina, A. I.; Gorshkov, A. G.; Shcherbakov, V. V.; Zinchenko, S. V.; Vereshchagin, A. L.; Zaikov, K. L.; Semenov, A. A. (1992). "Flavonolignans of Salsola collina". Chemistry of Natural Compounds. 28 (2): 155. doi:10.1007/BF00630164. S2CID 19700016.
- ^ Zapesochnaya, G. G.; Kurkin, V. A. (1983). "The flavonoids of the rhizomes ofRhodiola rosea. II. A flavonolignan and glycosides of herbacetin". Chemistry of Natural Compounds. 19: 21–29. doi:10.1007/BF00579955. S2CID 7656479.
- ^ Bouaziz M, Veitch NC, Grayer RJ, Simmonds MS, Damak M (July 2002). "Flavonolignans from Hyparrhenia hirta". Phytochemistry. 60 (5): 515–20. doi:10.1016/S0031-9422(02)00145-0. PMID 12052518.
- ^ Chemistry, University of; Prague, Technology. "Flavonolignans reduce the virulence of antibiotic-resistant bacterial strains". phys.org. Retrieved 2022-11-03.
External links
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