CENPO

CENPO
Identifiers
Aliases	CENPO, CENP-O, ICEN-36, MCM21R, centromere protein O
External IDs	OMIM: 611504; MGI: 1923800; HomoloGene: 49760; GeneCards: CENPO; OMA:CENPO - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	24,822,376 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	4,284,294 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; testicle; ; gonad; ; secondary oocyte; ; left testis; ; right testis; ; stromal cell of endometrium; ; mucosa of transverse colon; ; right adrenal cortex;
	Top expressed in
	primary oocyte; ; zygote; ; secondary oocyte; ; otic vesicle; ; spermatocyte; ; otic placode; ; saccule; ; lumbar subsegment of spinal cord; ; Paneth cell; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	chromosome; cytosol; chromosome, centromeric region; kinetochore; nucleoplasm; nucleus; Mis6-Sim4 complex;
Biological process	centromere complex assembly; CENP-A containing chromatin assembly;
	Sources:Amigo / QuickGO
Orthologs
	79172
	52504
	ENSG00000138092
	ENSMUSG00000020652
	Q9BU64
	Q8K015
	NM_001199803; NM_024322; NM_001322101
	NM_134046; NM_001361641
	NP_001186732; NP_001309030; NP_077298
	NP_598807; NP_001348570
	Wikidata
View/Edit Human	View/Edit Mouse

Centromere protein O is a protein that in humans is encoded by the CENPO gene.^[5]^[6]^[7] CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced. ^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138092 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020652 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420.
^ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419.
^ "Entrez Gene: CENPO centromere protein O".
^ Hewitt, Chelsee A.; Ling, King-Hwa; Merson, Tobias D.; Simpson, Ken M.; Ritchie, Matthew E.; King, Sarah L.; Pritchard, Melanie A.; Smyth, Gordon K.; Thomas, Tim (2010-07-16). "Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome". PLOS ONE. 5 (7): e11561. doi:10.1371/journal.pone.0011561. ISSN 1932-6203. PMC 2905390. PMID 20661276.{{cite journal}}: CS1 maint: unflagged free DOI (link)

External links

Human CENPO genome location and CENPO gene details page in the UCSC Genome Browser.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138092 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020652 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16622420-5] Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420.

[pmid16622419-6] Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419.

[entrez-7] "Entrez Gene: CENPO centromere protein O".

[8] Hewitt, Chelsee A.; Ling, King-Hwa; Merson, Tobias D.; Simpson, Ken M.; Ritchie, Matthew E.; King, Sarah L.; Pritchard, Melanie A.; Smyth, Gordon K.; Thomas, Tim (2010-07-16). "Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome". PLOS ONE. 5 (7): e11561. doi:10.1371/journal.pone.0011561. ISSN 1932-6203. PMC 2905390. PMID 20661276.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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References

External links

Further reading