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Thiamazole

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Not to be confused with metamizole, methazolamide, or methazole.

Thiamazole
Clinical data
Trade namesTapazole, others
Other namesthiamazole (INN, BAN); methimazole (USAN); MMI
AHFS/Drugs.comMonograph
MedlinePlusa682464
License data
Pregnancy
category
  • D (US)
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability93%
Protein bindingNone
MetabolismLiver
Elimination half-life5-6 hours
ExcretionKidney
Identifiers
  • 1-Methyl-3H-imidazole-2-thione
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.439 Edit this at Wikidata
Chemical and physical data
FormulaC4H6N2S
Molar mass114.17 g·mol−1
3D model (JSmol)
Melting point146 °C (295 °F)
Solubility in water275[1] mg/mL (20 °C)
  • Cn1cc[nH]c1=S
  • InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7) checkY
  • Key:PMRYVIKBURPHAH-UHFFFAOYSA-N checkY
  (verify)

Thiamazole, also known as methimazole, is a medication used to treat hyperthyroidism.[2] This includes Graves disease, toxic multinodular goiter, and thyrotoxic crisis.[2] It is taken by mouth.[2] Full effects may take a few weeks to occur.[3]

Common side effects include itchiness, hair loss, nausea, muscle pain, swelling, and abdominal pain.[2] Severe side effects may include low blood cell counts, liver failure, and vasculitis.[2] Use is not recommended during the first trimester of pregnancy but may be used in the second trimester or third trimester.[4] It may be used during breastfeeding.[4] Those who developed significant side effects may also have problems with propylthiouracil.[2] Thiamazole is a thioamide and works by decreasing the production of thyroid hormones.[2]

Thiamazole was approved for medical use in the United States in 1950.[2] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[5] It is available as a generic medication.[2] A month supply in the United States has a wholesale cost of about US$6.80.[6] It is also available in Europe and Asia.[7] In 2017, it was the 244th most commonly prescribed medication in the United States, with more than one million prescriptions.[8][9]

Medical uses

Thiamazole is a drug used to treat hyperthyroidism such as in Graves' disease, a condition that occurs when the thyroid gland begins to produce an excess of thyroid hormone. The drug may also be taken before thyroid surgery to lower thyroid hormone levels and minimize the effects of thyroid manipulation. Additionally, thiamazole is used in the veterinary setting to treat hyperthyroidism in cats.

Adverse effects

It is important to monitor any symptoms of fever or sore throat while taking thiamazole; this could indicate the development of agranulocytosis, an uncommon but severe side effect resulting from a drop in the white blood cell count (to be specific, neutropenia, a deficiency of neutrophils). A complete blood count (CBC) with differential is performed to confirm the suspicion, in which case the drug is discontinued.[10] Administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF) may increase recovery.

Other known side effects include:

Interactions

Adverse effects may occur for individuals who:

  • Take anticoagulants ('blood thinners') such as warfarin (Coumadin), diabetes medications, digoxin (Lanoxin), theophylline (Theobid, Theo-Dur), and vitamins
  • Have ever had any blood disease, such as decreased white blood cells (leukopenia), decreased platelets (thrombocytopenia) or aplastic anemia, or liver disease (hepatitis, jaundice)

Mechanism of action

Thiamazole inhibits the enzyme thyroperoxidase, which normally acts in thyroid hormone synthesis by oxidizing the anion iodide (I−) to iodine (I2), hypoiodous acid (HOI), enzyme linked hypoiodate (EOI) facilitating iodine's addition to tyrosine residues on the hormone precursor thyroglobulin, a necessary step in the synthesis of triiodothyronine (T3) and thyroxine (T4).

It does not inhibit the action of the sodium-dependent iodide transporter located on follicular cells' basolateral membranes. Inhibition of this step requires competitive inhibitors such as perchlorate and thiocyanate.

It acts at CXCL10.[11]

Chemical properties

The imidazole derivative thiamazole is a white to matte brown crystalline powder with a characteristic odour. The boiling point is 280 °C (decomposition). Thiamazole is soluble in water, ethanol and chloroform, but hardly soluble in ether.[12] Galenic preparations are injectable solutions and tablets.

Thiamazole acts as a free radical scavenger for radicals such as the hydroxyl radical (•OH) radical.[13] It is used as free radical scavenger in organic chemistry.[14]

References

  1. ^ "DrugBank: Methimazole (DB00763)". drugbank.ca. Retrieved 21 July 2015.
  2. ^ a b c d e f g h i "Methimazole Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 8 April 2019.
  3. ^ Spina, Domenico (2008). The Flesh and Bones of Medical Pharmacology E-Book. Elsevier Health Sciences. p. 74. ISBN 9780723437161.
  4. ^ a b "Methimazole Use During Pregnancy". Drugs.com. Retrieved 8 April 2019.
  5. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  6. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
  7. ^ Jastrzębska, Helena (2015). "Antithyroid drugs". Thyroid Research. 8 (Suppl 1): A12. doi:10.1186/1756-6614-8-S1-A12. PMC 4480840.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  8. ^ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
  9. ^ "Methimazole - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.
  10. ^ Fumarola, A; Di Fiore, A; Dainelli, M; Grani, G; Calvanese, A (November 2010). "Medical treatment of hyperthyroidism: state of the art". Experimental and Clinical Endocrinology & Diabetes. 118 (10): 678–84. doi:10.1055/s-0030-1253420. PMID 20496313.
  11. ^ Crescioli C, Cosmi L, Borgogni E, et al. (October 2007). "Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes". J. Endocrinol. 195 (1): 145–55. doi:10.1677/JOE-07-0240. PMID 17911406.
  12. ^ Entry on Thiamazol. at: Römpp Online. Georg Thieme Verlag, retrieved 10. November 2014.
  13. ^ Taylor, J.J.; Willson, R.L.; Kendall-Taylor, P. (29 October 1984). "Evidence for direct interactions between methimazole and free radicals". FEBS Letters. 176 (2): 337–340. doi:10.1016/0014-5793(84)81192-8.
  14. ^ Inhibition of amine oxide, 30 December 2010, retrieved 14 April 2019
  • "Methimazole". Drug Information Portal. U.S. National Library of Medicine.
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