Acetone–butanol–ethanol (ABE) fermentation is a process that uses bacterial fermentation to produce acetone, n-Butanol, and ethanol from carbohydrates such as starch and glucose. It was developed by the chemist Chaim Weizmann and was the primary process used to make acetone during World War I, such as to produce cordite, a substance essential for the British war industry.
The process may be likened to how yeast ferments sugars to produce ethanol for wine, beer, or fuel, but the organisms that carry out the ABE fermentation are strictly anaerobic (obligate anaerobes). The ABE fermentation produces solvents in a ratio of 3 parts acetone, 6 parts butanol to 1 part ethanol. It usually uses a strain of bacteria from the Class Clostridia (Family Clostridiaceae). Clostridium acetobutylicum is the most well-studied and widely used species, although Clostridium beijerinckii has also been used with good results.
In 1905, Austrian biochemist Franz Schardinger found that acetone could similarly be produced.
The Weizmann process was operated by Commercial Solvents Corporation from about 1920 to 1964 with plants in the US (Terre Haute, IN, and Peoria, IL), and Liverpool, England. The Peoria plant was the largest of the three; it used molasses as feedstock and had 96 50,000-gallon fermenters.
After World War II, ABE fermentation became generally non-profitable, compared to the production of the same three solvents (acetone, butanol, ethanol) from petroleum.
During the 1950s and 1960s, ABE fermentation was replaced by petroleum chemical plants. Due to different raw material costs, ABE fermentation was viable in South Africa until the early 1980s, with the last plant closing in 1983.
Currently there is one ABE plant operated by Green Biologics Ltd in Minnesota.
In order to make ABE fermentation profitable, many in-situ product recovery systems have been developed. These include gas stripping, pervaporation, membrane extraction, adsorption, and reverse osmosis. Green Biologics Ltd has implemented this at an industrial scale. 
- Mark R. Wilkins and Hasan Atiye (2012). "Fermentation". In Nurhan Turgut Dunford. Food and Industrial Bioproducts and Bioprocessing. Wiley. p. 195. ISBN 9781119946052.
- Qureshi N, Blaschek, HP. 2001. Recent advances in ABE fermentation: hyper-butanol producing Clostridium beijerinckii BA101. J Ind Microbiol Biotechnol 27(5):287-291.
- GB application 191504845, Charles Weizmann, "Improvements in the Bacterial Fermentation of Carbohydrates and in Bacterial Cultures for the same", published 1919-03-06, assigned to Charles Weizmann
- Fred C. Kelly (1936). One Thing Leads to Another: The Growth of an Industry, Houghton Mifflin
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