APOA2

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APOA2
Protein APOA2 PDB 1l6l.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases APOA2, Apo-AII, ApoA-II, apoAII, Apolipoprotein A2
External IDs MGI: 88050 HomoloGene: 1242 GeneCards: 336
RNA expression pattern
PBB GE APOA2 219465 at tn.png

PBB GE APOA2 219466 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001643

NM_013474
NM_001305549
NM_001305550
NM_001305585

RefSeq (protein)

NP_001634.1

NP_001292478.1
NP_001292479.1
NP_001292514.1
NP_038502.2

Location (UCSC) Chr 1: 161.22 – 161.22 Mb Chr 1: 171.23 – 171.23 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse
ApoA-II
PDB 1l6l EBI.jpg
structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions
Identifiers
Symbol ApoA-II
Pfam PF04711
InterPro IPR006801
SCOP 1l6k
SUPERFAMILY 1l6k

Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene.[3]

Function[edit]

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.[4]

Interactions[edit]

APOA2 has been shown to interact with PLTP.[5]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
|px|alt=Statin Pathway edit]]
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". 

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Tsao YK, Wei CF, Robberson DL, Gotto AM, Chan L (Dec 1985). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes". The Journal of Biological Chemistry. 260 (28): 15222–31. PMID 2415515. 
  4. ^ "Entrez Gene: APOA2 apolipoprotein A-II". 
  5. ^ Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". Journal of Lipid Research. 39 (1): 152–61. PMID 9469594. 

Further reading[edit]