APOA2

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APOA2
Protein APOA2 PDB 1l6l.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAPOA2, Apo-AII, ApoA-II, apoAII, Apolipoprotein A2
External IDsMGI: 88050 HomoloGene: 1242 GeneCards: APOA2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for APOA2
Genomic location for APOA2
Band1q23.3Start161,222,292 bp[1]
End161,223,631 bp[1]
RNA expression pattern
PBB GE APOA2 219465 at fs.png

PBB GE APOA2 219466 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001643

NM_013474
NM_001305549
NM_001305550
NM_001305585

RefSeq (protein)

NP_001634

NP_001292478
NP_001292479
NP_001292514
NP_038502

Location (UCSC)Chr 1: 161.22 – 161.22 MbChr 1: 171.23 – 171.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
ApoA-II
PDB 1l6l EBI.jpg
structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions
Identifiers
SymbolApoA-II
PfamPF04711
InterProIPR006801
SCOP1l6k
SUPERFAMILY1l6k

Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene.[5]

Function[edit]

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.[6]

Interactions[edit]

APOA2 has been shown to interact with PLTP.[7]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

[[File:
Statin_Pathway_WP430go to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
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Statin_Pathway_WP430go to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
|px|alt=Statin Pathway edit]]
Statin Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158874 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005681 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Tsao YK, Wei CF, Robberson DL, Gotto AM, Chan L (Dec 1985). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes". The Journal of Biological Chemistry. 260 (28): 15222–31. PMID 2415515.
  6. ^ "Entrez Gene: APOA2 apolipoprotein A-II".
  7. ^ Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". Journal of Lipid Research. 39 (1): 152–61. PMID 9469594.

External links[edit]

Further reading[edit]