Apolipoprotein D

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Apolipoprotein D
Protein APOD PDB 2APD.png
Rendering based on PDB 2APD.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol APOD
External IDs OMIM107740 MGI88056 HomoloGene1246 GeneCards: APOD Gene
RNA expression pattern
PBB GE APOD 201525 at tn.png
More reference expression data
Species Human Mouse
Entrez 347 11815
Ensembl ENSG00000189058 ENSMUSG00000022548
UniProt P05090 P51910
RefSeq (mRNA) NM_001647 NM_001301353
RefSeq (protein) NP_001638 NP_001288282
Location (UCSC) Chr 3:
195.57 – 195.58 Mb
Chr 16:
31.3 – 31.31 Mb
PubMed search [1] [2]

Apolipoprotein D is a protein that in humans is encoded by the APOD gene.[1][2][3] Unlike other lipoproteins, which are mainly produced in the liver, apolipoprotein D is mainly produced in the brain and testes.[4]


Apolipoprotein D (Apo-D) is a component of high-density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. It is a glycoprotein of estimated molecular weight 33 KDa. Apo-D is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism.[3]ApoD has also been shown to be an important link in the transient interaction between HDL and LDL particles and between HDL particles and cells.[5]

Clinical significance[edit]

APOD is a biomarker of androgen insensitivity syndrome (AIS). APOD is an androgen up-regulated gene in normal scrotal fibroblast cells in comparison to CAIS labia majora cells.[6]

APOD is associated with neurological disorders and nerve injury, especially related to myelin sheath. APOD was shown to be elevated in a rat model of stroke.[4] APOD is elevated in patients with schizophrenia, bipolar disorder, and Alzheimer's disease.[4]


  1. ^ Drayna DT, McLean JW, Wion KL, Trent JM, Drabkin HA, Lawn RM (Aug 1987). "Human apolipoprotein D gene: gene sequence, chromosome localization, and homology to the alpha 2u-globulin superfamily". DNA 6 (3): 199–204. doi:10.1089/dna.1987.6.199. PMID 2439269. 
  2. ^ Drayna D, Fielding C, McLean J, Baer B, Castro G, Chen E, Comstock L, Henzel W, Kohr W, Rhee L; et al. (Jan 1987). "Cloning and expression of human apolipoprotein D cDNA". J Biol Chem 261 (35): 16535–9. PMID 3453108. 
  3. ^ a b "Entrez Gene: APOD apolipoprotein D". 
  4. ^ a b c Muffat J, Walker DW (2010). "Apolipoprotein D: an overview of its role in aging and age-related diseases". Cell Cycle (journal) 9 (2): 269–273. doi:10.4161/cc.9.2.10433. PMC 3691099. PMID 20023409. 
  5. ^ Braesch-Andersen S; et al. (December 2014). "ApoD Mediates Binding of HDL to LDL and to Growing T24 Carcinoma". PLOS ONE 9 (12): e115180. doi:10.1371/journal.pone.0115180. PMID 25513803. 
  6. ^ Appari M, Werner R, Wünsch L, Cario G, Demeter J, Hiort O, Riepe F, Brooks JD, Holterhus PM (June 2009). "Apolipoprotein D (APOD) is a putative biomarker of androgen receptor function in androgen insensitivity syndrome". J. Mol. Med. 87 (6): 623–32. doi:10.1007/s00109-009-0462-3. PMID 19330472. 

Further reading[edit]

  • Rassart E, Bedirian A, Do Carmo S; et al. (2000). "Apolipoprotein D". Biochim. Biophys. Acta 1482 (1–2): 185–98. doi:10.1016/S0167-4838(00)00162-X. PMID 11058760. 
  • Peitsch MC, Boguski MS (1991). "Is apolipoprotein D a mammalian bilin-binding protein?". New Biol. 2 (2): 197–206. PMID 2083249. 

External links[edit]