Apolipoprotein C2

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APOC2
Protein APOC2 PDB 1by6.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAPOC2, APO-CII, APOC-II, apolipoprotein C2
External IDsOMIM: 608083 MGI: 88054 HomoloGene: 47928 GeneCards: APOC2
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for APOC2
Genomic location for APOC2
Band19q13.32Start44,945,982 bp[1]
End44,949,565 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000483

NM_001277944
NM_001309795

RefSeq (protein)

NP_000474
NP_000474.2

NP_001296728

Location (UCSC)Chr 19: 44.95 – 44.95 MbChr 7: 19.67 – 19.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Apo-CII
1i5j.jpg
nmr structure of human apolipoprotein c-ii in the presence of sds
Identifiers
Symbol Apo-CII
Pfam PF05355
InterPro IPR008019
SCOP 1by6
SUPERFAMILY 1by6

Apolipoprotein C2 or apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene.

The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries,[5] which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by xanthomas, pancreatitis, and hepatosplenomegaly, but no increased risk for atherosclerosis. Lab tests will show elevated blood levels of triglycerides, cholesterol, and chylomicrons[6]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

[[File:
Statin_Pathway_WP430go to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
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Statin_Pathway_WP430go to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
|px|alt=Statin Pathway edit]]
Statin Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". 

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000234906 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002992 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kim SY, Park SM, Lee ST (2006). "Apolipoprotein C-II is a novel substrate for matrix metalloproteinases". Biochem. Biophys. Res. Commun. 339 (1): 47–54. doi:10.1016/j.bbrc.2005.10.182. PMID 16314153. 
  6. ^ "Entrez Gene: APOC2 apolipoprotein C-II". 

External links[edit]