Aceperone
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| Other names | Acetabuton; R 3248 |
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| Formula | C24H29FN2O2 |
| Molar mass | 396.498 g/mol g·mol−1 |
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| Melting point | 97 to 100 °C (207 to 212 °F) [1] |
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Aceperone is a neuroleptic drug of the butyrophenone class. It is an α-noradrenergic blocking drug developed by Janssen Pharmaceutica in the 1960s.[1]
Aceperone has been used as a tool in the study of the biochemical basis of learning. Although aceperone does not block learning per se, it blocks access to an attentional mechanism by which animals ‘tune in’ to the relevant visual dimension when learning a visual discimination task[2][3] at doses below those that affect general behaviour.[4]
References
- ^ a b Alkoxylamino and alkoxycarbonylamino derivatives of 1(aroylalkyl)-4-arylpiperidines. Janssen, Paul A. J. (1961) BE 606849
- ^ Ridley, R. M.; Haystead, T. A. J.; Baker, H. F.; Crow, T. J. (1981). "A new approach to the role of noradrenaline in learning: problem-solving in the marmoset after α-noradrenergic receptor blockade". Pharmacology, Biochemistry and Behavior. 14 (6): 849–855. doi:10.1016/0091-3057(81)90373-7.
- ^ Baker, H.F.; Ridley, R.M.; Haystead, T.A.J.; Crow, T.J. (1983). "Further consideration of the learning impairment after aceperone in the marmoset: Effects of the drug on shape and colour discrimination and on an alternation task". Pharmacology Biochemistry and Behavior. 18 (5): 701. doi:10.1016/0091-3057(83)90009-6.
- ^ Scraggs, P. R.; Ridley, R. M. (1979). "The effect of dopamine and noradrenaline blockade on amphetamine-induced behaviour in the marmoset". Psychopharmacology. 62 (1): 41–5. doi:10.1007/BF00426033. PMID 155838.
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