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Systematic (IUPAC) name
Clinical data
Trade names Prolixin, Modecate, Moditen others
AHFS/Drugs.com Monograph
MedlinePlus a682172
  • AU: C
  • US: C (Risk not ruled out)
Routes of
Oral, IM, depot injection (fluphenazine decanoate)
Legal status
Legal status
Pharmacokinetic data
Bioavailability 2.7% (Oral)
Metabolism unclear[1]
Biological half-life IM 15 hours (HCL), 7-10 days (decanoate)[1]
Excretion Urine, faeces
CAS Number 69-23-8 YesY
ATC code N05AB02 (WHO)
PubChem CID 3372
DrugBank DB00623 YesY
ChemSpider 3255 YesY
UNII S79426A41Z YesY
KEGG D07977 YesY
Chemical data
Formula C22H26F3N3OS
Molar mass 437.523 g/mol

Fluphenazine, sold under the brand names Prolixin among others, is an antipsychotic medication.[1] It is used in the treatment of chronic psychoses such as schizophrenia,[1][2] and appears to be about equal in effectiveness to low-potency antipsychotics.[3] It is given by mouth, injection into a muscle, or just under the skin.[1] There is a long acting injectable version that may last for up to four weeks.[1]

Common side effects include movement problems, sleepiness, and increased weight. Serious side effects may include the potentially permanent movement disorder tardive dyskinesia, neuroleptic malignant syndrome, and low white blood cell levels. In older people with psychosis as a result of dementia it may increase the risk of dying. It may also increase prolactin levels which may result in milk production. It is unclear if it is safe for use in pregnancy. Fluphenazine is a typical antipsychotic of the phenothiazine class. Its mechanism of action is not entirely clear but believed to be related to its ability as a dopamine antagonist.[1]

Fluphenazine came into use in 1959.[4] It is on the World Health Organization's List of Essential Medicines, most important medication needed in a basic health system.[5] It is available as a generic medication.[1] In the United States the pills costs between 0.22 and 0.42 USD per day for a typical dose.[1] The wholesale cost in the developing world of the long acting form is between 0.20 and 6.20 USD per injection as of 2014.[6]


  1. ^ a b c d e f g h i "fluphenazine decanoate". The American Society of Health-System Pharmacists. Retrieved Dec 1, 2015. 
  2. ^ "Product Information: Modecate (Fluphenazine Decanoate Oily Injection)" (PDF). TGA eBusiness Services. Bristol-Myers Squibb Australia Pty Ltd. 1 November 2012. Retrieved 9 December 2013. 
  3. ^ Tardy, M; Huhn, M; Engel, RR; Leucht, S (Aug 3, 2014). "Fluphenazine versus low-potency first-generation antipsychotic drugs for schizophrenia.". The Cochrane database of systematic reviews. 8: CD009230. doi:10.1002/14651858.CD009230.pub2. PMID 25087165. 
  4. ^ McPherson, Edwin M. (2007). Pharmaceutical Manufacturing Encyclopedia. (3rd ed.). Burlington: Elsevier. p. 1680. ISBN 9780815518563. 
  5. ^ "WHO Model List of Essential Medicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014. 
  6. ^ "Fluphenazine Decanoate". International Drug Price Indicator Guide. Retrieved 2 December 2015.