|Systematic (IUPAC) name|
|Trade names||Prolixin, Modecate, Moditen others|
|Oral, IM, depot injection (fluphenazine decanoate)|
|Biological half-life||IM 15 hours (HCL), 7-10 days (decanoate)|
|Molar mass||437.523 g/mol|
Fluphenazine, sold under the brand names Prolixin among others, is a antipsychotic medication. It is used in the treatment of chronic psychoses such as schizophrenia. It is given by mouth, injection into a muscle, or just under the skin. There is a long acting injectable version that may last for up to four weeks.
Common side effects include movement problems, sleepiness, and increased weight. Serious side effects may include the potentially permanent movement disorder tardive dyskinesia, neuroleptic malignant syndrome, and low white blood cell levels. In older people with psychosis as a result of dementia it may increase the risk of dying. It may also increase prolactin levels which may result in milk production. It is unclear if it is safe for use in pregnancy. Fluphenazine is a typical antipsychotic of the phenothiazine class. Its mechanism of action is not entirely clear but believed to be related to its ability as a dopamine antagonist.
Fluphenazine came into use in 1959. It is on the World Health Organization's List of Essential Medicines, most important medication needed in a basic health system. It is available as a generic medication. In the United States the pills costs between 0.22 and 0.42 USD per day for a typical dose. The wholesale cost of the long acting form is between 0.20 and 6.20 USD per injection as of 2014.
- Common adverse effects (i.e. those that have an incidence ≥1%) include
- Orthostatic hypotension
- Somnolence/ drowsiness
- Weight gain
- Erectile dysfunction
- Oligomenorrhea or amenorrhea
- Anticholinergic effects, such as:
- - Dry mouth
- - Constipation
- - Nasal congestion
- - Blurred vision
- - Diminished sweating
- Extrapyramidal side effects, such as:
- - Tremor
- - Akathisia
- - Muscle rigidity
- - Dystonia
- - Parkinsonism
- Epithelial keratopathy
- Eye / vision finding
- Retinitis pigmentosa
- Uncommon side effects (0.1%≤incidence<1%) include
- Cerebral oedema
- Ineffective temperature regulation
- Weight loss
- Lens opacities (with prolonged use)
- Ejaculatory disorder
- QT interval prolongation
- Rare (incidence<0.1%) side effects include
- Unknown frequency side effects include
- Decreased gag reflex
- Silent pneumonia (likely rare)
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- Tardy, M; Huhn, M; Engel, RR; Leucht, S (Aug 3, 2014). "Fluphenazine versus low-potency first-generation antipsychotic drugs for schizophrenia.". The Cochrane database of systematic reviews 8: CD009230. doi:10.1002/14651858.CD009230.pub2. PMID 25087165.
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- "Modecate Concentrate Injection 100mg/ml - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Sanofi. 11 January 2013. Retrieved 9 December 2013.
- "Fluphenazine". Davis's Drug Guide for Nurses, Eighth Edition. F.A. Davis Company, 2005. ISBN 0-8036-2455-7.
- Fluphenazine - http://www.minddisorders.com/Flu-Inv/Fluphenazine.html#b#ixzz28etEdxu8 - dose, children, effects, therapy, adults, withdrawal, drug, person