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Buflomedil

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This is an old revision of this page, as edited by DePiep (talk | contribs) at 16:18, 30 November 2015 (Chembox: move all ATCCode-parameters into section Parmacology. See WP:Chembox talk#Drugbank_and_ATC_positioning (+minor param corrections) (via AWB script)). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Buflomedil
Names
IUPAC name
4-(pyrrolidin-1-yl)-1-(2,4,6-trimethoxyphenyl)butan-1-one
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.054.393 Edit this at Wikidata
UNII
  • InChI=1S/C17H25NO4/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18/h11-12H,4-10H2,1-3H3 checkY
    Key: OWYLAEYXIQKAOL-UHFFFAOYSA-N checkY
  • InChI=1/C17H25NO4/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18/h11-12H,4-10H2,1-3H3
    Key: OWYLAEYXIQKAOL-UHFFFAOYAG
  • O=C(c1c(OC)cc(OC)cc1OC)CCCN2CCCC2
Properties
C17H25NO4
Molar mass 307.38 g/mol
Pharmacology
C04AX20 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Buflomedil is a vasoactive drug used to treat claudication or the symptoms of peripheral arterial disease. It is currently not approved by the Food and Drug Administration (FDA) for use in the United States. Currently available as trade name tablet Loftyl

Toxicity

This drug might be suspended from marketing in the European Union, because of concerns about severe neurological and cardiac toxicity.[1][2] In its press release dated 17 November 2011 EMA suggested that doctors "should stop using buflomedil and consider alternative treatment options".

Various adverse effects have been reported to the FDA.[3]

References