Mel Allen was impressed enough with Desmond that he asked him to come to New York City as his sidekick on the home games of the Yankees and Giants in 1942. After one year, he left and joined with Red Barber on the Dodgers broadcasts, replacing Al Helfer. During the 1943 season, Barber and Desmond were the only voices of baseball in New York; the Giants and Yankees suspended broadcasts that year for unknown reasons. Desmond remained with the Dodgers until 1956, teaming with Barber (1943–1953), Ernie Harwell (1948–1949), and Vin Scully (1950–1956). In the 1940s Desmond also teamed with Barber to call college football and New York Giants football, and with Marty Glickman to call college basketball and New York Knicks basketball.
Desmond battled alcoholism for many years, and frequently missed games because he was too drunk to go on the air. Dodgers owner Walter O'Malley finally lost patience with him and fired him before the 1955 World Series—thus missing a chance to call the Dodgers' only world title on the East Coast. Desmond asked for and got another chance in 1956, but was fired for good after several more absences. He was succeeded by Jerry Doggett.
Desmond died March 10, 1983 in Toledo, Ohio at the age of 75.
- "Connie Desmond". The New York Times. March 13, 1983.
- Smith, Curt (2005). Voices of Summer. New York City: Carroll & Graf. ISBN 0-7867-1446-8.