May 12 – Carl Erskine tosses the second no-hitter of his career as the Brooklyn Dodgers blank the New York Giants, 3–0, at Ebbets Field. His first no-hitter came on June 19, 1952 against the Chicago Cubs at Ebbets Field.
May 26 – Al Simmons died in Milwaukee, at the age of 54. A former Philadelphia Athletics outfielder as well as a three-time All-Star and two-time champion bat, Simmons posted a .334 average with 307 home runs and 1827 RBI in a 20-season major league career that included stints with six other teams besides the Athletics. Simmons was enshrined into the Hall of Fame in 1953.
May 30 – Mickey Mantle of the New York Yankees narrowly misses hitting the first home run ever hit completely out of Yankee Stadium. With Hank Bauer and Gil McDougald on base in the fifth inning of Game One of a doubleheader against the Washington Senators, Mantle, batting left-handed against Pedro Ramos, hits a towering drive above the level of the stadium roof. However, a stiff wind cuts down the ball, which strikes the right-field facade, 18 inches (460 mm) above the level of the roof. The home run gives the Yankees a 3-1 lead; they go on to win 4-3.
August 8 – Robin Roberts wins his eighth straight game and his fourth in 10 days‚ as the visiting Philadelphia Phillies defeat the New York Giants‚ 9–3. Phillies shortstop Ted Kazanski lines an inside-the-park grand slam off Jim Hearn‚ just the fourth in club history to pace the attack.
September 30 – Chicago White Sox pitcher Jim Derrington becomes the youngest pitcher in modern history to start a game. He loses to the Kansas City Athletics, 7-6, at the age of 16 years and 10 months.
October 9 – The Dodgers bounce back. Brooklyn's Clem Labine comes out of the bullpen to pitch a 1-0 victory for the Dodgers in Game 6 of the World Series. Yankee Enos Slaughter misjudges Jackie Robinson's fly ball, and Jim Gilliam scores from second base; it turned out to be Robinson's last major league hit. The series is tied at 3 games apiece.
October 10 – The New York Yankees defeat the Brooklyn Dodgers, 9-0, in Game 7 of the World Series to win their seventeenth World Championship, four games to three. Johnny Kucks goes the distance in the victory, allowing only three hits. Yogi Berra hits a pair of 2-run home runs and Bill Skowron hits a grand slam. Don Newcombe takes the loss, his fourth in Series competition. It was the last World Series game being played at Brooklyn's Ebbets Field. Yankees pitcher Don Larsen is named Most Valuable Player.
Don Newcombe, who posted a 27-7 record with 139 strikeouts and a 3.06 ERA for the National League pennant-winning Brooklyn Dodgers, becomes the first MLB Cy Young Award winner. Only one pitcher will be selected each season for this prestigious pitching award until 1967, when each league will name a winner.