DBT (gene)

DBT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K8M, 1K8O, 1ZWV, 2COO, 3RNM
Identifiers
Aliases	DBT, BCATE2, BCKAD-E2, BCKADE2, E2, E2B, BCOADC-E2, dihydrolipoamide branched chain transacylase E2, BCKDH-E2
External IDs	OMIM: 248610; MGI: 105386; HomoloGene: 1444; GeneCards: DBT; OMA:DBT - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	100,249,834 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	116,343,630 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; renal medulla; ; endothelial cell; ; cardia; ; ventral tegmental area; ; nipple; ; pylorus; ; trigeminal ganglion; ; external globus pallidus; ; inferior ganglion of vagus nerve;
	Top expressed in
	brown adipose tissue; ; parotid gland; ; intercostal muscle; ; left lobe of liver; ; lacrimal gland; ; epithelium of stomach; ; retinal pigment epithelium; ; human kidney; ; right kidney; ; myocardium of ventricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	acyltransferase activity; ubiquitin protein ligase binding; transferase activity; dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity; acetyltransferase activity; lipoic acid binding;
Cellular component	mitochondrial matrix; mitochondrial alpha-ketoglutarate dehydrogenase complex; mitochondrial nucleoid; mitochondrion; cytoplasm;
Biological process	metabolism; branched-chain amino acid catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1629
	13171
	ENSG00000137992
	ENSMUSG00000000340
	P11182
	P53395
	NM_001918
	NM_010022; NM_001357344
	NP_001909
	NP_034152; NP_001344273
	Wikidata
View/Edit Human	View/Edit Mouse

Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial is an enzyme that in humans is encoded by the DBT gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137992 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000340 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lau KS, Chuang JL, Herring WJ, Danner DJ, Cox RP, Chuang DT (Dec 1992). "The complete cDNA sequence for dihydrolipoyl transacylase (E2) of human branched-chain alpha-keto acid dehydrogenase complex". Biochim Biophys Acta. 1132 (3): 319–21. doi:10.1016/0167-4781(92)90169-z. PMID 1420314.
^ Lau KS, Herring WJ, Chuang JL, McKean M, Danner DJ, Cox RP, Chuang DT (Dec 1992). "Structure of the gene encoding dihydrolipoyl transacylase (E2) component of human branched chain alpha-keto acid dehydrogenase complex and characterization of an E2 pseudogene". J Biol Chem. 267 (33): 24090–6. PMID 1429740.
^ "Entrez Gene: DBT dihydrolipoamide branched chain transacylase E2".

v t e Aldehyde/oxo oxidoreductases (EC 1.2)
1.2.1: NAD or NADP	Aldehyde dehydrogenase Acetaldehyde dehydrogenase Long-chain-aldehyde dehydrogenase Mycothiol-dependent formaldehyde dehydrogenase
1.2.2: cytochrome	Formate dehydrogenase (cytochrome)
1.2.3: oxygen	Aldehyde oxidase
1.2.4: disulfide	Oxoglutarate dehydrogenase complex Pyruvate dehydrogenase Branched-chain alpha-keto acid dehydrogenase complex BCKDHA BCKDHB DBT DLD
1.2.7: iron–sulfur protein	Pyruvate synthase

v t e Enzymes: multienzyme complexes
Photosynthesis	Photosynthetic reaction center complex proteins Photosystem I II
Dehydrogenase	Pyruvate dehydrogenase complex E1 E2 E3 Oxoglutarate dehydrogenase OGDH DLST DLD Branched-chain alpha-keto acid dehydrogenase complex BCKDHA BCKDHB DBT DLD
Other	CAD Carbamoyl phosphate synthase II Aspartate carbamoyltransferase Dihydroorotase P450-containing systems Cytochrome b6f complex Electron transport chain Fatty acid synthetase complex Glycine decarboxylase complex Mitochondrial trifunctional protein HADHA HADHB Phosphoenolpyruvate sugar phosphotransferase system Polyketide synthase Sucrase-isomaltase complex Tryptophan synthase

References

Further reading