Endothelin 3

EDN3
Identifiers
Aliases	EDN3, ET-3, ET3, HSCR4, PPET3, WS4B, endothelin 3
External IDs	OMIM: 131242; MGI: 95285; HomoloGene: 88; GeneCards: EDN3; OMA:EDN3 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	59,325,992 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	174,625,835 bp
RNA expression pattern
	Top expressed in
	human penis; ; jejunal mucosa; ; gonad; ; islet of Langerhans; ; duodenum; ; vulva; ; mucosa of ileum; ; rectum; ; parotid gland; ; testicle;
	Top expressed in
	iris; ; genital tubercle; ; cecum; ; left lung lobe; ; lumbar subsegment of spinal cord; ; intestinal villus; ; jejunum; ; embryo; ; pineal gland; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	hormone activity; endothelin B receptor binding; signaling receptor binding;
Cellular component	extracellular region; intracellular anatomical structure; extracellular space;
Biological process	positive regulation of MAP kinase activity; regulation of systemic arterial blood pressure by endothelin; vasoconstriction; cell-cell signaling; blood circulation; neutrophil chemotaxis; positive regulation of heart rate; multicellular organism development; positive regulation of leukocyte chemotaxis; cell surface receptor signaling pathway; vein smooth muscle contraction; regulation of vasoconstriction; peptide hormone secretion; positive regulation of cell differentiation; artery smooth muscle contraction; regulation of gene expression; inositol phosphate-mediated signaling; positive regulation of mitotic nuclear division; positive regulation of hormone secretion; signal transduction; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; neural crest cell migration; cellular calcium ion homeostasis; positive regulation of cell population proliferation; cellular magnesium ion homeostasis; neuron differentiation; melanocyte differentiation; regulation of cell migration; regulation of developmental pigmentation; positive regulation of potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	1908
	13616
	ENSG00000124205
	ENSMUSG00000027524
	P14138
	P48299
NM_000114; NM_207032; NM_207033; NM_207034; NM_001302455;
	NM_001302456
	NM_007903
	NP_001289384; NP_001289385; NP_996915; NP_996916; NP_996917
	NP_031929
	Wikidata
View/Edit Human	View/Edit Mouse

Endothelin-3 is a protein that in humans is encoded by the EDN3 gene.^[5]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124205 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027524 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EDN3 endothelin 3".

v t e Intercellular signaling peptides and proteins / ligands
Growth factors	Epidermal growth factor Fibroblast growth factor Nerve growth factor Platelet-derived growth factor Transforming growth factor beta superfamily Vascular endothelial growth factor
Ephrin	EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3
Other	Adipokine Agouti signaling protein Agouti-related protein Angiogenic protein CCN intercellular signaling protein Cysteine-rich protein 61 Connective tissue growth factor Nephroblastoma overexpressed protein Cytokine Endothelin EDN1 EDN2 EDN3 Hedgehog protein Interferon Kinin Parathyroid hormone-related protein Semaphorin Somatomedin Tolloid-like metalloproteinase Tumor necrosis factor Wnt protein
see also extracellular ligand disorders

References

Further reading