Free fatty acid receptor 2

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Aliases FFAR2, FFA2R, GPR43, free fatty acid receptor 2
External IDs MGI: 2441731 HomoloGene: 133911 GeneCards: FFAR2
Targeted by Drug
butyric acid, isobutyric acid, (E)-2,3-dimethylacrylic acid, valeric acid, propionic acid[1]
RNA expression pattern
PBB GE FFAR2 221345 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)


Location (UCSC) Chr 19: 35.44 – 35.45 Mb Chr 7: 30.82 – 30.82 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor encoded by the FFAR2 gene.[4]


FFAR2 mRNA is expressed in adipose tissue, pancreas, spleen, lymph nodes, bone marrow, and peripheral blood mononuclear cells.[5][6] FFAR2 transcription is regulated by the XBP1 transcription factor which binds to the core promoter.[7]


Mouse studies utilizing Ffar2 gene deletions have implicated the receptor in the regulation of energy metabolism and immune responses.[8] However, discrepancies between the pathways activated by FFAR2 agonists in human cells and the equivalent murine counterparts have been observed.[9][10][11]

See also[edit]


  1. ^ "Drugs that physically interact with Free fatty acid receptor 2 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Entrez Gene: FFAR2 free fatty acid receptor 2". 
  5. ^ Nilsson NE, Kotarsky K, Owman C, Olde B (2003). "Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids.". Biochem. Biophys. Res. Commun. 303 (4): 1047–52. doi:10.1016/S0006-291X(03)00488-1. PMID 12684041. 
  6. ^ Le Poul E, Loison C, Struyf S (2003). "Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.". J. Biol. Chem. 278 (28): 25481–9. doi:10.1074/jbc.M301403200. PMID 12711604. 
  7. ^ Ang Z, Er JZ, Ding JL (2015). "The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes.". Sci Rep. 5: 8134. doi:10.1038/srep08134. PMID 25633224. 
  8. ^ Bindels, Laure B.; Dewulf, Evelyne M.; Delzenne, Nathalie M. (2013-04-01). "GPR43/FFA2: physiopathological relevance and therapeutic prospects". Trends in Pharmacological Sciences. 34 (4): 226–232. doi:10.1016/ ISSN 1873-3735. PMID 23489932. 
  9. ^ Dewulf, Evelyne M.; Ge, Qian; Bindels, Laure B.; Sohet, Florence M.; Cani, Patrice D.; Brichard, Sonia M.; Delzenne, Nathalie M. (2013-01-17). "Evaluation of the relationship between GPR43 and adiposity in human". Nutrition & Metabolism. 10 (1): 11. doi:10.1186/1743-7075-10-11. PMC 3577645Freely accessible. PMID 23327542. 
  10. ^ Priyadarshini, Medha; Villa, Stephanie R.; Fuller, Miles; Wicksteed, Barton; Mackay, Charles R.; Alquier, Thierry; Poitout, Vincent; Mancebo, Helena; Mirmira, Raghavendra G. (2015-07-01). "An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion". Molecular Endocrinology (Baltimore, Md.). 29 (7): 1055–1066. doi:10.1210/me.2015-1007. ISSN 1944-9917. PMC 4484778Freely accessible. PMID 26075576. 
  11. ^ Ang, Zhiwei; Er, Jun Zhi; Tan, Nguan Soon; Lu, Jinhua; Liou, Yih-Cherng; Grosse, Johannes; Ding, Jeak Ling (2016-09-26). "Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists". Scientific Reports. 6: 34145. doi:10.1038/srep34145. ISSN 2045-2322. PMC 5036191Freely accessible. PMID 27667443. 

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