Free fatty acid receptor 2

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Free fatty acid receptor 2
Identifiers
Symbols FFAR2 ; FFA2R; GPR43
External IDs OMIM603823 MGI2441731 HomoloGene133911 IUPHAR: 226 ChEMBL: 5493 GeneCards: FFAR2 Gene
RNA expression pattern
PBB GE FFAR2 221345 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2867 233079
Ensembl ENSG00000126262 ENSMUSG00000051314
UniProt O15552 Q8VCK6
RefSeq (mRNA) NM_005306 NM_001168509
RefSeq (protein) NP_005297 NP_001161981
Location (UCSC) Chr 19:
35.44 – 35.45 Mb
Chr 7:
30.82 – 30.82 Mb
PubMed search [1] [2]

Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor encoded by the FFAR2 gene.[1]


Expression[edit]

FFAR2 mRNA is expressed in adipose tissue, pancreas, spleen, lymph nodes, bone marrow, and peripheral blood mononuclear cells.[2][3] FFAR2 transcription is regulated by the XBP1 transcription factor which binds to the core promoter.[4]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: FFAR2 free fatty acid receptor 2". 
  2. ^ Nilsson NE, Kotarsky K, Owman C, Olde B (2003). "Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids.". Biochem. Biophys. Res. Commun. 303 (4): 1047–52. doi:10.1016/S0006-291X(03)00488-1. PMID 12684041. 
  3. ^ Le Poul E, Loison C, Struyf S (2003). "Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.". J. Biol. Chem. 278 (28): 25481–9. doi:10.1074/jbc.M301403200. PMID 12711604. 
  4. ^ Ang Z, Er JZ, Ding JL. (2015). "The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes.". Sci Rep. 5: 8134. doi:10.1038/srep08134. PMID 25633224. 

External links[edit]

Further reading[edit]