Free fatty acid receptor 2

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FFAR2
Identifiers
AliasesFFAR2, FFA2R, GPR43, free fatty acid receptor 2
External IDsMGI: 2441731 HomoloGene: 133911 GeneCards: FFAR2
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for FFAR2
Genomic location for FFAR2
Band19q13.12Start35,443,907 bp[1]
End35,451,767 bp[1]
RNA expression pattern
PBB GE FFAR2 221345 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005306
NM_001370087

NM_001168509
NM_001168510
NM_001168511
NM_001168512
NM_146187

RefSeq (protein)

NP_005297
NP_001357016

NP_001161981
NP_001161982
NP_001161983
NP_001161984
NP_666299

Location (UCSC)Chr 19: 35.44 – 35.45 MbChr 7: 30.82 – 30.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Free fatty acid receptor 2 (FFAR2) is a G-protein coupled receptor encoded by the FFAR2 gene.[5]

Expression[edit]

FFAR2 mRNA is expressed in adipose tissue, pancreas, spleen, lymph nodes, bone marrow, and peripheral blood mononuclear cells.[6][7] FFAR2 transcription is regulated by the XBP1 transcription factor which binds to the core promoter.[8]

Function[edit]

Mouse studies utilizing Ffar2 gene deletions have implicated the receptor in the regulation of energy metabolism and immune responses.[9] Short Chain Fatty Acids (SCFA's) generated in the processing of fiber by intestinal microbiota act as ligands for the receptor and can affect neutrophil chemotaxis.[10] [11] However, discrepancies between the pathways activated by FFAR2 agonists in human cells and the equivalent murine counterparts have been observed.[12][13][14]

Heteromerization[edit]

FFAR2 may interact with FFAR3 to form a FFAR2-FFAR3 receptor heteromer with signalling that is distinct from the parent homomers.[15]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126262 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051314 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: FFAR2 free fatty acid receptor 2".
  6. ^ Nilsson NE, Kotarsky K, Owman C, Olde B (2003). "Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids". Biochem. Biophys. Res. Commun. 303 (4): 1047–52. doi:10.1016/S0006-291X(03)00488-1. PMID 12684041.
  7. ^ Le Poul E, Loison C, Struyf S (2003). "Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation". J. Biol. Chem. 278 (28): 25481–9. doi:10.1074/jbc.M301403200. PMID 12711604.
  8. ^ Ang Z, Er JZ, Ding JL (2015). "The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes". Sci. Rep. 5: 8134. doi:10.1038/srep08134. PMC 4311239. PMID 25633224.
  9. ^ Bindels, Laure B.; Dewulf, Evelyne M.; Delzenne, Nathalie M. (2013-04-01). "GPR43/FFA2: physiopathological relevance and therapeutic prospects". Trends in Pharmacological Sciences. 34 (4): 226–232. doi:10.1016/j.tips.2013.02.002. ISSN 1873-3735. PMID 23489932.
  10. ^ Yang, Guan (2018). "Implication of G Protein-Coupled Receptor 43 in Intestinal Inflammation: A Mini-Review". Front. Immunol. 9: 1434. doi:10.3389/fimmu.2018.01434. PMC 6023978. PMID 29988393.
  11. ^ D'Souza, WN (2017-07-20). "Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses". PLoS One. 12 (7): e0180190. doi:10.1371/journal.pone.0180190. PMC 5519041. PMID 28727837.
  12. ^ Dewulf, Evelyne M.; Ge, Qian; Bindels, Laure B.; Sohet, Florence M.; Cani, Patrice D.; Brichard, Sonia M.; Delzenne, Nathalie M. (2013-01-17). "Evaluation of the relationship between GPR43 and adiposity in human". Nutrition & Metabolism. 10 (1): 11. doi:10.1186/1743-7075-10-11. PMC 3577645. PMID 23327542.
  13. ^ Priyadarshini, Medha; Villa, Stephanie R.; Fuller, Miles; Wicksteed, Barton; Mackay, Charles R.; Alquier, Thierry; Poitout, Vincent; Mancebo, Helena; Mirmira, Raghavendra G. (2015-07-01). "An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion". Molecular Endocrinology. 29 (7): 1055–1066. doi:10.1210/me.2015-1007. ISSN 1944-9917. PMC 4484778. PMID 26075576.
  14. ^ Ang, Zhiwei; Er, Jun Zhi; Tan, Nguan Soon; Lu, Jinhua; Liou, Yih-Cherng; Grosse, Johannes; Ding, Jeak Ling (2016-09-26). "Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists". Scientific Reports. 6: 34145. doi:10.1038/srep34145. ISSN 2045-2322. PMC 5036191. PMID 27667443.
  15. ^ Ang, Zhiwei; Xiong, Ding; Wu, Min; Ding, Jeak Ling (2017-09-07). "FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing". The FASEB Journal. 32 (1): –201700252RR. doi:10.1096/fj.201700252RR. ISSN 0892-6638. PMC 5731126. PMID 28883043. Retrieved 2017-09-10.

Further reading[edit]

External links[edit]