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Skeletal formula of fursultiamine
Ball-and-stick model of the fursultiamine molecule
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
ATC code
  • None
Legal status
Legal status
CAS Number
PubChem CID
ECHA InfoCard100.011.234 Edit this at Wikidata
Chemical and physical data
Molar mass398.54 g·mol−1
3D model (JSmol)

Fursultiamine (INN; chemical name thiamine tetrahydrofurfuryl disulfide or TTFD; brand names Adventan, Alinamin-F, Benlipoid, Bevitol Lipophil, Judolor, Lipothiamine) is a medication and vitamin used to treat thiamine deficiency. Chemically, it is a disulfide derivative of thiamine and is similar in structure to allithiamine.[1]

It was synthesized in Japan in the 1960s from allithiamine for the purpose of developing forms of thiamine with improved lipophilicity for treating vitamin B1 deficiency (i.e., beriberi),[1][2] It was subsequently commercialized not only in Japan but also in Spain, Austria, Germany, and the United States.[3] As a vitamin, it is available over-the-counter as well.[4]

See also[edit]


  1. ^ a b Lonsdale D (September 2004). "Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent". Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 10 (9): RA199–203. PMID 15328496.
  2. ^ Miura S (July 1965). "[The uptake and the distribution of thiamine propyl disulfide-35S by the rabbit's eye tissue]". Nippon Ganka Gakkai Zasshi (in Japanese). 69 (7): 792–807, discussion 807–8. PMID 5006719.
  3. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 1932. ISBN 3-88763-075-0.
  4. ^ Nozaki S, Mizuma H, Tanaka M, et al. (December 2009). "Thiamine tetrahydrofurfuryl disulfide improves energy metabolism and physical performance during physical-fatigue loading in rats". Nutrition Research. 29 (12): 867–72. doi:10.1016/j.nutres.2009.10.007. PMID 19963160.

Further reading[edit]