Gamma-D-Glutamyl-meso-diaminopimelate peptidase
| Gamma-D-glutamyl-meso-diaminopimelate peptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.19.11 | ||||||||
| CAS no. | 62572-28-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Gamma-D-glutamyl-meso-diaminopimelate peptidase (EC 3.4.19.11, endopeptidase I, gamma-D-glutamyldiaminopimelate endopeptidase, gamma-D-glutamyl-L-meso-diaminopimelate peptidoglycan hydrolase, gamma-glutamyl-L-meso-diaminopimelyl endopeptidase, gamma-D-glutamyl-meso-diaminopimelate endopeptidase, gamma-D-glutamyl-meso-diaminopimelic peptidoglycan hydrolase, gamma-D-glutamyl-meso-diaminopimelic endopeptidase, gamma-D-glutamyl-meso-D-aminopimelic endopeptidase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of gamma-D-glutamyl bonds to the L-terminus (position 7) of meso-diaminopimelic acid (meso-A2pm) in 7-(L-Ala-gamma-D-Glu)-meso-A2pm and 7-(L-Ala-gamma-D-Glu)-7-(D-Ala)-meso-A2pm. It is required that the D-terminal amino and carboxy groups of meso-A2pm are unsubstituted
This metallopeptidase is isolate from Bacillus sphaericus.
References
- ^ Arminjon, F.; Guinand, M.; Vacheron, M.-J.; Michel, G. (1977). "Specificity profiles of the membrane-bound γ-D-glutamyl-(L)meso-diaminopimelate endopeptidase and LD-carboxypeptidase from Bacillus sphaericus 9602". Eur. J. Biochem. 73: 557–565. doi:10.1111/j.1432-1033.1977.tb11351.x. PMID 849747.
- ^ Garnier, M.; Vacheron, M.-J.; Guinard, M.; Michel, G. (1985). "Purification and partial characterization of the extracellular γ-D-glutamyl-(L)meso-diaminopimelate endopeptidase I, from Bacillus sphaericus NCTC 9602". Eur. J. Biochem. 148: 539–543. doi:10.1111/j.1432-1033.1985.tb08873.x. PMID 3922755.
- ^ Hourdou, M.-L.; Guinand, M.; Vacheron, M.-J.; Michel, G.; Denoroy, L.; Duez, C.; Englebert, S.; Joris, B.; Weber, G.; Ghuysen, J.-M. (1993). "Characterization of the sporulation-related γ-D-glutamyl-(L)meso-diaminopimelic-acid-hydrolysing peptidase I of Bacillus sphaericus NCTC 9602 as a member of the metallo(zinc) carboxypeptidase A family. Modular design of the protein". Biochem. J. 292: 563–570. PMID 8503890.
External links
- Gamma-D-glutamyl-meso-diaminopimelate+peptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)