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Gingipain is a protease secreted by Porphyromonas gingivalis. Among other functions, they work to degrade cytokines, thereby downregulating the host response in the form of reduced inflammation.[1]


  1. ^ Stathopoulou, PG. Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species. J Clin Perio 2010;37:24–29