Hydrazine (antidepressant)

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Iproniazid, the first hydrazine MAOI to be discovered.

The hydrazine antidepressants are a group of non-selective, irreversible monoamine oxidase inhibitors (MAOIs) which were discovered and initially marketed in the 1950s and 1960s. Most have been withdrawn due to toxicity, namely hepatotoxicity, but a few still remain in clinical use.

Tranylcypromine, a structurally unrelated MAOI introduced around the same time as the hydrazines, was originally advertised as non-hydrazine as a result of its diminished propensity for causing hepatotoxicity.

List of hydrazine antidepressants[edit]


Legend: = Withdrawn from the market; = Partially discontinued; Bolded names indicate major drugs.

Never marketed[edit]