LRP1B

LRP1B
Identifiers
Aliases	LRP1B, LRP-DIT, LRPDIT, LDL receptor related protein 1B, LRP-1B
External IDs	OMIM: 608766; MGI: 2151136; HomoloGene: 56810; GeneCards: LRP1B; OMA:LRP1B - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	142,131,016 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	42,543,636 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; Region I of hippocampus proper; ; Skeletal muscle tissue of rectus abdominis; ; glutes; ; testicle; ; prefrontal cortex; ; primary visual cortex; ; anterior cingulate cortex; ; amygdala;
	Top expressed in
	zygote; ; facial motor nucleus; ; dentate gyrus; ; dentate gyrus of hippocampal formation granule cell; ; lumbar subsegment of spinal cord; ; dorsal striatum; ; superior frontal gyrus; ; primary visual cortex; ; ventromedial nucleus; ; globus pallidus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding;
Cellular component	integral component of membrane; receptor complex; membrane;
Biological process	protein transport; endocytosis; receptor-mediated endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	53353
	94217
	ENSG00000168702
	ENSMUSG00000049252
	Q9NZR2
	Q9JI18
	NM_018557
	NM_053011
	NP_061027
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Low-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1B gene.^[5]^[6]

Function

LRP1B belongs to the LDL receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168702 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049252 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liu CX, Musco S, Lisitsina NM, Forgacs E, Minna JD, Lisitsyn NA (May 2000). "LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines". Cancer Res. 60 (7): 1961–7. PMID 10766186.
^ "Entrez Gene: LRP1B low density lipoprotein-related protein 1B (deleted in tumors)".
^ Liu CX, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G (August 2001). "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein". J. Biol. Chem. 276 (31): 28889–96. doi:10.1074/jbc.M102727200. PMID 11384978.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Liu CX, Musco S, Lisitsina NM, et al. (2001). "Genomic organization of a new candidate tumor suppressor gene, LRP1B". Genomics. 69 (2): 271–4. doi:10.1006/geno.2000.6331. PMID 11031110.
Langbein S, Szakacs O, Wilhelm M, et al. (2002). "Alteration of the LRP1B gene region is associated with high grade of urothelial cancer". Lab. Invest. 82 (5): 639–43. doi:10.1038/labinvest.3780458. PMID 12004004.
Li Y, Knisely JM, Lu W, et al. (2003). "Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration". J. Biol. Chem. 277 (44): 42366–71. doi:10.1074/jbc.M207705200. PMID 12194987.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cam JA, Zerbinatti CV, Knisely JM, et al. (2004). "The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production". J. Biol. Chem. 279 (28): 29639–46. doi:10.1074/jbc.M313893200. PMID 15126508.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Tanaga K, Bujo H, Zhu Y, et al. (2005). "LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptors". Arterioscler. Thromb. Vasc. Biol. 24 (8): 1422–8. doi:10.1161/01.ATV.0000133607.80554.09. PMID 15166012.
Sonoda I, Imoto I, Inoue J, et al. (2004). "Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma". Cancer Res. 64 (11): 3741–7. doi:10.1158/0008-5472.CAN-04-0172. PMID 15172977.
Li Y, Lu W, Bu G (2005). "Striking differences of LDL receptor-related protein 1B expression in mouse and human". Biochem. Biophys. Res. Commun. 333 (3): 868–73. doi:10.1016/j.bbrc.2005.05.170. PMID 15963947.
Pastrana DV, Hanson AJ, Knisely J, et al. (2006). "LRP 1 B functions as a receptor for Pseudomonas exotoxin". Biochim. Biophys. Acta. 1741 (3): 234–9. doi:10.1016/j.bbadis.2005.06.007. PMID 16095885.
Nakagawa T, Pimkhaokham A, Suzuki E, et al. (2006). "Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma". Cancer Sci. 97 (10): 1070–4. doi:10.1111/j.1349-7006.2006.00283.x. PMID 16918994.
Liu CX, Ranganathan S, Robinson S, Strickland DK (2007). "gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells". J. Biol. Chem. 282 (10): 7504–11. doi:10.1074/jbc.M608088200. PMID 17227771.{{cite journal}}: CS1 maint: unflagged free DOI (link)

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168702 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049252 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10766186-5] Liu CX, Musco S, Lisitsina NM, Forgacs E, Minna JD, Lisitsyn NA (May 2000). "LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines". Cancer Res. 60 (7): 1961–7. PMID 10766186.

[entrez-6] "Entrez Gene: LRP1B low density lipoprotein-related protein 1B (deleted in tumors)".

[pmid11384978-7] Liu CX, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G (August 2001). "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein". J. Biol. Chem. 276 (31): 28889–96. doi:10.1074/jbc.M102727200. PMID 11384978.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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v t e Lipids: lipoprotein particle metabolism
Lipoprotein particle classes and subclasses	delivery of TGs: Chylomicron VLDL delivery of C and CE: IDL LDL lb LDL sd LDL Lp(a) HDL Remnant cholesterol
Apolipoproteins	APOA 1 2 4 5 APOB APOC 1 2 3 4 APOD APOE APOH SAA SAA1
Extracellular enzymes	LCAT LIPC LPL
Lipid transfer proteins	CETP MTTP PLTP
Cell surface receptors	HDL: SCARB1 IDL: LRP LRP1 LRP1B LRP2 LRP3 LRP4 LRP5 LRP5L LRP6 LRP8 LRP10 LRP11 LRP12 LDL: LDLR LRPAP1
ATP-binding cassette transporter	ABCA1 ABCG5 ABCG8

Function

References

Further reading