|Wild lettuce (Lactuca virosa)|
L. 1753 not Thunb. 1800 nor Luce nor Hablitz
Lactuca virosa is a plant in the Lactuca (lettuce) genus, ingested often for its mild psychotropic (specifically hypnotic or sedative) effects which are often described as being similar to those of opium. It is related to common lettuce (L. sativa), and is often called wild lettuce, bitter lettuce, laitue vireuse, opium lettuce, poisonous lettuce, tall lettuce, great lettuce or rakutu-karyumu-so.
Lactuca virosa is widespread across much of central and southern Europe. It can be found locally in the south east and east of England. In the rest of Great Britain it is very rare, and in Ireland it is absent. It is also found in the Punjab Region of Pakistan India and Australia where it grows in the wild.
Lactuca virosa is biennial, similar to prickly lettuce Lactuca serriola but taller - it can grow to 200 cm (80 inches or almost 7 feet). It is also stouter, the stem and leaves are more purple flushed,[disputed ] the leaves are less divided, but more spreading.
In the northern hemisphere, it flowers from July until September.
Lactuca virosa was used in the 19th century by physicians when opium could not be obtained. It was studied extensively by the Council of the Pharmaceutical Society of Great Britain in 1911. They discovered two chemicals responsible for the properties of L. virosa; lactucopicrin and lactucin. In the United States, the plant experienced a resurgence in popularity in the 1970s. Today the plant is un-scheduled by the Food and Drug Administration (FDA), meaning it is legal to grow, purchase and own without prescription or license.
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A latex which is called lactucarium can be derived from the extract of the stem secretions of Lactuca virosa. Oils and extracts can also be produced from L. virosa. These oils and extracts have sedative properties in rodents.
Lactuca virosa contains flavonoids, coumarins, and N-methyl-β-phenethylamine.[unreliable source?] A variety of other chemical compounds have been isolated from L. virosa. One of the compounds, lactucin, is an adenosine receptor agonist in vitro, while another, lactucopicrin, has been shown to act as an acetylcholinesterase inhibitor in vitro.
- The Plant List, Lactuca virosa L.
- Wesołowska, A.; Nikiforuk, A.; Michalska, K.; Kisiel, W.; Chojnacka-Wójcik, E. (2006). "Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice". Journal of Ethnopharmacology. 107 (2): 254–8. doi:10.1016/j.jep.2006.03.003. PMID 16621374.
- "BSBI List 2007" (xls). Botanical Society of Britain and Ireland. Retrieved 2014-10-17.
- Altervista Flora Italiana, Lactuca virosa L. includes photos and European distribution map
- Flora of North America, Lactuca virosa Linnaeus, 1753.
- Rose, Francis (1981). The Wild Flower Key. Frederick Warne & Co. pp. 391–392. ISBN 0-7232-2419-6.
- Holistic Online herb information: Wild Lettuce
- Rollinger, JM; Mocka, P; Zidorn, C; Ellmerer, EP; Langer, T; Stuppner, H (2005). "Application of the in combo screening approach for the discovery of non-alkaloid acetylcholinesterase inhibitors from Cichorium intybus". Current drug discovery technologies. 2 (3): 185–93. doi:10.2174/1570163054866855. PMID 16472227.
|Wikimedia Commons has media related to Lactuca virosa.|
- Lactuca virosa United States Department of Agriculture Plants Profile
- Wild lettuce Vaults of Erowid
- photo of herbarium specimen at Missouri Botanical Garden