History of general anesthesia

From Wikipedia, the free encyclopedia

Re-enactment of the first public demonstration of general anesthesia by William T. G. Morton on October 16, 1846, in the Ether Dome at Massachusetts General Hospital, Boston. Surgeons John Collins Warren and Henry Jacob Bigelow are included in this daguerrotype by Southworth & Hawes.
The Bulfinch Building, home of the Ether Dome

Throughout recorded history, attempts at producing a state of general anesthesia can be traced back to the writings of ancient Sumerians, Babylonians, Assyrians, Egyptians, Indians, and Chinese. Despite significant advances in anatomy and surgical technique during the Renaissance, surgery remained a last-resort treatment largely due to the pain associated with it. However, scientific discoveries in the late 18th and early 19th centuries paved the way for the development of modern anesthetic techniques.[citation needed]

In the late 19th century, two major advances enabled the transition to modern surgery: the development and application of antiseptic techniques as a result of the germ theory of disease, which reduced morbidity and mortality rates, and the advances in pharmacology and physiology that led to the development of general anesthesia and pain control. In the 20th century, general anesthesia's safety and efficacy were further improved with the routine use of tracheal intubation and advanced airway management techniques, monitoring, and new anesthetic agents with improved characteristics. Standardized training programs for anesthesiologists and nurse anesthetists emerged during this period.

Moreover, the application of economic and business administration principles to healthcare in the late 20th and early 21st centuries led to the introduction of management practices, such as transfer pricing, to improve the efficiency of anesthetists.[1]

Etymology of anesthesia[edit]

In Ancient Greek texts, including the Hippocratic Corpus, Timaeus, and others, the term ἀναισθησίᾱ (anaisthēsíā, "without sensation") is attested; from ἀν- (an-, "without") and αἴσθησις (aisthēsis, "sensation").[2][3]

In 1679, Steven Blankaart publishes Lexicon medicum graeco-latinum with the Latin term anaisthesia. In 1684, an English translation appears titled A Physical Dictionary, with anaisthesia defined as "defect of sensation, as in paralytic and blasted persons". Subsequently, the term and variant spellings like anæsthesia are used in medical literature signifying "insensibility".[2]

In 1846, in a letter, Oliver Wendell Holmes proposes the term anesthesia to be used for the state induced by an agent and anesthetic for the agent itself. Holmes motivates this with earlier uses of anesthesia in medical literature to mean "insensibility", particularly to "objects of touch".[4][5][2]


The first attempts at general anesthesia were probably herbal remedies administered in prehistory. Alcohol is the oldest known sedative; it was used in ancient Mesopotamia thousands of years ago.[6]


Opium poppy, Papaver somniferum

The Sumerians are said to have cultivated and harvested the opium poppy (Papaver somniferum) in lower Mesopotamia as early as 3400 BC,[7][8] though this has been disputed.[9] The most ancient testimony concerning the opium poppy found to date was inscribed in cuneiform script on a small white clay tablet at the end of the third millennium BC. This tablet was discovered in 1954 during excavations at Nippur, and is currently kept at the University of Pennsylvania Museum of Archaeology and Anthropology. Deciphered by Samuel Noah Kramer and Martin Leve, it is considered to be the most ancient pharmacopoeia in existence.[10][11] Some Sumerian tablets of this era have an ideogram inscribed upon them, "hul gil", which translates to "plant of joy", believed by some authors to refer to opium.[12][13] The term gil is still used for opium in certain parts of the world.[14] The Sumerian goddess Nidaba is often depicted with poppies growing out of her shoulders. About 2225 BC, the Sumerian territory became a part of the Babylonian empire. Knowledge and use of the opium poppy and its euphoric effects thus passed to the Babylonians, who expanded their empire eastwards to Persia and westwards to Egypt, thereby extending its range to these civilizations.[14] British archaeologist and cuneiformist Reginald Campbell Thompson writes that opium was known to the Assyrians in the 7th century BC.[15] The term "Arat Pa Pa" occurs in the Assyrian Herbal, a collection of inscribed Assyrian tablets dated to c. 650 BC. According to Thompson, this term is the Assyrian name for the juice of the poppy and it may be the etymological origin of the Latin "papaver".[12]

The ancient Egyptians had some surgical instruments,[16][17] as well as crude analgesics and sedatives, including possibly an extract prepared from the mandrake fruit.[18] The use of preparations similar to opium in surgery is recorded in the Ebers Papyrus, an Egyptian medical papyrus written in the Eighteenth Dynasty.[14][16][19] However, it is questionable whether opium itself was known in ancient Egypt.[20] The Greek gods Hypnos (Sleep), Nyx (Night), and Thanatos (Death) were often depicted holding poppies.[21]

Prior to the introduction of opium to ancient India and China, these civilizations pioneered the use of cannabis incense and aconitum. c. 400 BC, the Sushruta Samhita (a text from the Indian subcontinent on Ayurvedic medicine and surgery) advocates the use of wine with incense of cannabis for anesthesia.[22] By the 8th century AD, Arab traders had brought opium to India[23] and China.[24]

Classical antiquity[edit]

In Classical antiquity, anaesthetics were described by:

China and Hua Tuo's Ancient Chemical Mixture[edit]

Hua Tuo, Chinese surgeon, c. AD 200

Bian Que (Chinese: 扁鵲, Wade–Giles: Pien Ch'iao, c. 300 BC) was a legendary Chinese internist and surgeon who reportedly used general anesthesia for surgical procedures. It is recorded in the Book of Master Han Fei (c. 250 BC), the Records of the Grand Historian (c. 100 BC), and the Book of Master Lie (c. 300 AD) that Bian Que gave two men, named "Lu" and "Chao", a toxic drink which rendered them unconscious for three days, during which time he performed a gastrostomy upon them.[25][26][27]

Hua Tuo (Chinese:華佗, c. 145–220 AD) was a Chinese surgeon of the 2nd century AD. According to the Records of Three Kingdoms (c. 270 AD) and the Book of the Later Han (c. 430 AD), Hua Tuo performed surgery under general anesthesia using a formula he had developed by mixing wine with a mixture of herbal extracts he called mafeisan (麻沸散).[28] Hua Tuo reportedly used mafeisan to perform even major operations such as resection of gangrenous intestines.[28][29][30] Before the surgery, he administered an oral anesthetic potion, probably dissolved in wine, in order to induce a state of unconsciousness and partial neuromuscular blockade.[28]

The exact composition of mafeisan, similar to all of Hua Tuo's clinical knowledge, was lost when he burned his manuscripts, just before his death.[31] The composition of the anesthetic powder was not mentioned in either the Records of Three Kingdoms or the Book of the Later Han. Because Confucian teachings regarded the body as sacred and surgery was considered a form of body mutilation, surgery was strongly discouraged in ancient China. Because of this, despite Hua Tuo's reported success with general anesthesia, the practice of surgery in ancient China ended with his death.[28]

The name mafeisan combines ma (, meaning "cannabis, hemp, numbed or tingling"), fei (, meaning "boiling or bubbling"), and san (, meaning "to break up or scatter", or "medicine in powder form"). Therefore, the word mafeisan probably means something like "cannabis boil powder". Many sinologists and scholars of traditional Chinese medicine have guessed at the composition of Hua Tuo's mafeisan powder, but the exact components still remain unclear. His formula is believed to have contained some combination of:[28][31][32][33]

Others have suggested the potion may have also contained hashish,[29] bhang,[30] shang-luh,[25] or opium.[34] Victor H. Mair wrote that mafei "appears to be a transcription of some Indo-European word related to "morphine"."[35] Some authors believe that Hua Tuo may have discovered surgical analgesia by acupuncture, and that mafeisan either had nothing to do with or was simply an adjunct to his strategy for anesthesia.[36] Many physicians have attempted to re-create the same formulation based on historical records but none have achieved the same clinical efficacy as Hua Tuo's. In any event, Hua Tuo's formula did not appear to be effective for major operations.[35][37]

Other substances used from antiquity for anesthetic purposes include extracts of juniper and coca.[38][39][40]

Middle Ages and Renaissance[edit]

Ferdowsi (940–1020) was a Persian poet who lived in the Abbasid Caliphate. In Shahnameh, his national epic poem, Ferdowsi described a caesarean section performed on Rudaba.[citation needed] A special wine prepared by a Zoroastrian priest was used as an anesthetic for this operation.[25]

c. 1020, Ibn Sīnā (980–1037) in The Canon of Medicine described the "soporific sponge", a sponge imbued with aromatics and narcotics, which was to be placed under a patient's nose during surgical operations.[41][42][43] Opium made its way from Asia Minor to all parts of Europe between the 10th and 13th centuries.[44]

Throughout 1200–1500 AD in England, a potion called dwale was used as an anesthetic.[45] This alcohol-based mixture contained bile, opium, lettuce, bryony, henbane, hemlock, and vinegar.[45] Surgeons roused their patients by rubbing vinegar and salt on their cheekbones.[45] One can find records of dwale in numerous literary sources, including Shakespeare's Hamlet, and the John Keats poem "Ode to a Nightingale".[45] In the 13th century, we have the first prescription of the "spongia soporifica"—a sponge soaked in the juices of unripe mulberry, flax, mandragora leaves, ivy, lettuce seeds, lapathum, and hemlock with hyoscyamus. After treatment and/or storage, the sponge could be heated and the vapors inhaled with anesthetic effect.[citation needed]

Alchemist Ramon Llull has been credited with discovering diethyl ether in 1275.[citation needed] [45] Aureolus Theophrastus Bombastus von Hohenheim (1493–1541), better known as Paracelsus, discovered the analgesic properties of diethyl ether around 1525.[46] It was first synthesized in 1540 by Valerius Cordus, who noted some of its medicinal properties.[citation needed] He called it oleum dulce vitrioli, a name that reflects the fact that it is synthesized by distilling a mixture of ethanol and sulfuric acid (known at that time as oil of vitriol). August Sigmund Frobenius gave the name Spiritus Vini Æthereus to the substance in 1730.[47][48]

18th century[edit]

Satirical cartoon by James Gillray showing a Royal Institution lecture, with Humphry Davy holding the bellows and Count Rumford looking on at extreme right

Joseph Priestley (1733–1804) was an English polymath who discovered nitrous oxide, nitric oxide, ammonia, hydrogen chloride, and (along with Carl Wilhelm Scheele and Antoine Lavoisier) oxygen. Beginning in 1775, Priestley published his research in Experiments and Observations on Different Kinds of Air, a six-volume work.[49] The recent discoveries about these and other gases stimulated a great deal of interest in the European scientific community. Thomas Beddoes (1760–1808) was an English philosopher, physician and teacher of medicine, and like his older colleague Priestley, was also a member of the Lunar Society of Birmingham. With an eye toward making further advances in this new science as well as offering treatment for diseases previously thought to be untreatable (such as asthma and tuberculosis), Beddoes founded the Pneumatic Institution for inhalation gas therapy in 1798 at Dowry Square in Clifton, Bristol.[50] Beddoes employed chemist and physicist Humphry Davy (1778–1829) as superintendent of the institute, and engineer James Watt (1736–1819) to help manufacture the gases. Other members of the Lunar Society such as Erasmus Darwin and Josiah Wedgwood were also actively involved with the institute.

During the course of his research at the Pneumatic Institution, Davy discovered the anesthetic properties of nitrous oxide.[51] Davy, who coined the term "laughing gas" for nitrous oxide, published his findings the following year in the now-classic treatise, Researches, chemical and philosophical–chiefly concerning nitrous oxide or dephlogisticated nitrous air, and its respiration. Davy was not a physician, and he never administered nitrous oxide during a surgical procedure. He was, however, the first to document the analgesic effects of nitrous oxide, as well as its potential benefits in relieving pain during surgery:[52]

"As nitrous oxide in its extensive operation appears capable of destroying physical pain, it may probably be used with advantage during surgical operations in which no great effusion of blood takes place."

19th century[edit]

Eastern hemisphere[edit]

Takamine Tokumei from Shuri, Ryūkyū Kingdom, is reported to have made a general anesthesia in 1689 in the Ryukyus, now known as Okinawa. He passed on his knowledge to the Satsuma doctors in 1690 and to Ryūkyūan doctors in 1714.[53]

Hanaoka Seishū, a Japanese surgeon of the 18th and 19th centuries

Hanaoka Seishū (華岡 青洲, 1760–1835) of Osaka was a Japanese surgeon of the Edo period with a knowledge of Chinese herbal medicine, as well as Western surgical techniques he had learned through Rangaku (literally "Dutch learning", and by extension "Western learning"). Beginning in about 1785, Hanaoka embarked on a quest to re-create a compound that would have pharmacologic properties similar to Hua Tuo's mafeisan.[54] After years of research and experimentation, he finally developed a formula which he named tsūsensan (also known as mafutsu-san). Like that of Hua Tuo, this compound was composed of extracts of several different plants, including:[55][56][57]

  • 2 parts bai zhi (Chinese:白芷Angelica dahurica);
  • 2 parts cao wu (Chinese:草烏Aconitum sp., monkshood or wolfsbane);
  • 2 parts chuān ban xia (Pinellia ternata);
  • 2 parts chuān xiōng (Ligusticum wallichii, Cnidium rhizome, Cnidium officinale or Szechuan lovage);
  • 2 parts dong quai (Angelica sinensis or female ginseng);
  • 1 part tian nan xing (Arisaema rhizomatum or cobra lily)
  • 8 parts yang jin hua (Datura stramonium, Korean morning glory, thorn apple, jimson weed, devil's trumpet, stinkweed, or locoweed).

The active ingredients in tsūsensan are scopolamine, hyoscyamine, atropine, aconitine and angelicotoxin. When consumed in sufficient quantity, tsūsensan produces a state of general anesthesia and skeletal muscle paralysis.[57] Shutei Nakagawa (1773–1850), a close friend of Hanaoka, wrote a small pamphlet titled "Mayaku-ko" ("narcotic powder") in 1796. Although the original manuscript was lost in a fire in 1867, this brochure described the current state of Hanaoka's research on general anesthesia.[58]

On 13 October 1804, Hanaoka performed a partial mastectomy for breast cancer on a 60-year-old woman named Kan Aiya, using tsūsensan as a general anaesthetic. This is generally regarded today as the first reliable documentation of an operation to be performed under general anesthesia.[54][56][59][60] Hanaoka went on to perform many operations using tsūsensan, including resection of malignant tumors, extraction of bladder stones, and extremity amputations. Before his death in 1835, Hanaoka performed more than 150 operations for breast cancer.[54][60][61][62]

Western hemisphere[edit]

Gardner Quincy Colton, 19th-century American dentist
Horace Wells, 19th-century American dentist
Crawford W. Long, 19th-century American physician
William T. G. Morton, 19th-century American dentist

Friedrich Sertürner (1783–1841) first isolated morphine from opium in 1804;[63] he named it morphine after Morpheus, the Greek god of dreams.[64][full citation needed][65][full citation needed]

Henry Hill Hickman (1800–1830) experimented with the use of carbon dioxide as an anesthetic in the 1820s. He would make the animal insensible, effectively via almost suffocating it with carbon dioxide, then determine the effects of the gas by amputating one of its limbs. In 1824, Hickman submitted the results of his research to the Royal Society in a short treatise titled Letter on suspended animation: with the view of ascertaining its probable utility in surgical operations on human subjects. The response was an 1826 article in The Lancet titled "Surgical Humbug" that ruthlessly criticised his work. Hickman died four years later at age 30. Though he was unappreciated at the time of his death, his work has since been positively reappraised and he is now recognised as one of the fathers of anesthesia.

By the late 1830s, Humphry Davy's experiments had become widely publicized within academic circles in the northeastern United States. Wandering lecturers would hold public gatherings, referred to as "ether frolics", where members of the audience were encouraged to inhale diethyl ether or nitrous oxide to demonstrate the mind-altering properties of these agents while providing much entertainment to onlookers.[66] Four notable men participated in these events and witnessed the use of ether in this manner. They were William Edward Clarke (1819–1898), Crawford W. Long (1815–1878), Horace Wells (1815–1848), and William T. G. Morton (1819–1868).

While attending undergraduate school in Rochester, New York, in 1839, classmates Clarke and Morton apparently participated in ether frolics with some regularity.[67][68][69][70] In January 1842, by now a medical student at Berkshire Medical College, Clarke administered ether to a Miss Hobbie, while Elijah Pope performed a dental extraction.[68] In so doing, he became the first to administer an inhaled anesthetic to facilitate the performance of a surgical procedure. Clarke apparently thought little of his accomplishment, and chose neither to publish nor to pursue this technique any further. Indeed, this event is not even mentioned in Clarke's biography.[71]

Crawford W. Long was a physician and pharmacist practicing in Jefferson, Georgia in the mid-19th century. During his time as a student at the University of Pennsylvania School of Medicine in the late 1830s, he had observed and probably participated in the ether frolics that had become popular at that time. At these gatherings, Long observed that some participants experienced bumps and bruises, but afterward had no recall of what had happened. He postulated that diethyl ether produced pharmacologic effects similar to those of nitrous oxide. On 30 March 1842, he administered diethyl ether by inhalation to a man named James Venable, in order to remove a tumor from the man's neck.[72] Long later removed a second tumor from Venable, again under ether anesthesia. He went on to employ ether as a general anesthetic for limb amputations and childbirth. Long, however, did not publish his experience until 1849, thereby denying himself much of the credit he deserved.[72]

With the beginnings of modern medicine the stage was set for physicians and surgeons to build a paradigm in which anesthesia became useful.[73]

On 10 December 1844, Gardner Quincy Colton held a public demonstration of nitrous oxide in Hartford, Connecticut. One of the participants, Samuel A. Cooley, sustained a significant injury to his leg while under the influence of nitrous oxide without noticing the injury. Horace Wells, a Connecticut dentist present in the audience that day, immediately seized upon the significance of this apparent analgesic effect of nitrous oxide. The following day, Wells underwent a painless dental extraction while under the influence of nitrous oxide administered by Colton. Wells then began to administer nitrous oxide to his patients, successfully performing several dental extractions over the next couple of weeks.

William T. G. Morton, another New England dentist, was a former student and then-current business partner of Wells. He was also a former acquaintance and classmate of William Edward Clarke (the two had attended undergraduate school together in Rochester, New York). Morton arranged for Wells to demonstrate his technique for dental extraction under nitrous oxide general anesthesia at Massachusetts General Hospital, in conjunction with the prominent surgeon John Collins Warren. This demonstration, which took place on 20 January 1845, ended in failure when the patient cried out in pain in the middle of the operation.[74]

On 30 September 1846, Morton administered diethyl ether to Eben Frost, a music teacher from Boston, for a dental extraction. Two weeks later, Morton became the first to publicly demonstrate the use of diethyl ether as a general anesthetic at Massachusetts General Hospital, in what is known today as the Ether Dome.[75] On 16 October 1846, John Collins Warren removed a tumor from the neck of a local printer, Edward Gilbert Abbott. Upon completion of the procedure, Warren reportedly quipped, "Gentlemen, this is no humbug." News of this event rapidly traveled around the world.[76] Robert Liston performed the first amputation in December of that year. Morton published his experience soon after.[75] Harvard University professor Charles Thomas Jackson (1805–1880) later claimed that Morton stole his idea;[77] Morton disagreed and a lifelong dispute began.[76] For many years, Morton was credited as being the pioneer of general anesthesia in the Western hemisphere, despite the fact that his demonstration occurred four years after Long's initial experience. Long later petitioned William Crosby Dawson (1798–1856), a United States Senator from Georgia at that time, to support his claim on the floor of the United States Senate as the first to use ether anesthesia.[78]

In 1847, Scottish obstetrician James Young Simpson (1811–1870) of Edinburgh was the first to use chloroform as a general anesthetic on a human (Robert Mortimer Glover had written on this possibility in 1842 but only used it on dogs). The use of chloroform anesthesia expanded rapidly thereafter in Europe. Chloroform began to replace ether as an anesthetic in the United States at the beginning of the 20th century. It was soon abandoned in favor of ether when its hepatic and cardiac toxicity, especially its tendency to cause potentially fatal cardiac dysrhythmias, became apparent. In fact, the use of chloroform versus ether as the primary anesthetic gas varied by country and region. For instance, Britain and the American South stuck with chloroform while the American North returned to ether.[73] John Snow quickly became the most experienced British physician working with the new anesthetic gases of ether and chloroform thus becoming, in effect, the first British anesthetist. Through his careful clinical records he was eventually able to convince the elite of London medicine that anesthesia (chloroform) had a rightful place in childbirth. Thus, in 1853 Queen Victoria's accoucheurs invited John Snow to anesthetize the Queen for the birth of her eighth child.[79] From the beginnings of ether and chloroform anesthesia until well into the 20th century, the standard method of administration was the drop mask. A mask was placed over the patient's mouth with some fabric in it and the volatile liquid was dropped onto the mask with the patient spontaneously breathing. Later development of safe endotracheal tubes changed this.[80] Because of the unique social setting of London medicine, anesthesia had become its own speciality there by the end of the nineteenth century, while in the rest of the United Kingdom and most of the world anesthesia remained under the purview of the surgeon who would assign the task to a junior doctor or nurse.[73]

After Austrian diplomat Karl von Scherzer brought back sufficient quantities of coca leaves from Peru, in 1860 Albert Niemann isolated cocaine, which thus became the first local anesthetic.[81][82]

In 1871, the German surgeon Friedrich Trendelenburg (1844–1924) published a paper describing the first successful elective human tracheotomy to be performed for the purpose of administration of general anesthesia.[83][84][85][86]

In 1880, the Scottish surgeon William Macewen (1848–1924) reported on his use of orotracheal intubation as an alternative to tracheotomy to allow a patient with glottic edema to breathe, as well as in the setting of general anesthesia with chloroform.[87][88][89] All previous observations of the glottis and larynx (including those of Manuel García,[90] Wilhelm Hack[91][92] and Macewen) had been performed under indirect vision (using mirrors) until 23 April 1895, when Alfred Kirstein (1863–1922) of Germany first described direct visualization of the vocal cords. Kirstein performed the first direct laryngoscopy in Berlin, using an esophagoscope he had modified for this purpose; he called this device an autoscope.[93] The death of Emperor Frederick III (1831–1888)[94] may have motivated Kirstein to develop the autoscope.[95]

20th century[edit]

Hermann Emil Fischer, German chemist

The 20th century saw the transformation of the practices of tracheotomy, endoscopy and non-surgical tracheal intubation from rarely employed procedures to essential components of the practices of anesthesia, critical care medicine, emergency medicine, gastroenterology, pulmonology, and surgery.

In 1902, Hermann Emil Fischer (1852–1919) and Joseph von Mering (1849–1908) discovered that diethylbarbituric acid was an effective hypnotic agent.[96] Also called barbital or Veronal (the trade name assigned to it by Bayer Pharmaceuticals), this new drug became the first commercially marketed barbiturate; it was used as a treatment for insomnia from 1903 until the mid-1950s.

Until 1913, oral and maxillofacial surgery was performed by mask inhalation anesthesia, topical application of local anesthetics to the mucosa, rectal anesthesia, or intravenous anesthesia. While otherwise effective, these techniques did not protect the airway from obstruction and also exposed patients to the risk of pulmonary aspiration of blood and mucus into the tracheobronchial tree. In 1913, Chevalier Jackson (1865–1958) was the first to report a high rate of success for the use of direct laryngoscopy as a means to intubate the trachea.[97] Jackson introduced a new laryngoscope blade that had a light source at the distal tip, rather than the proximal light source used by Kirstein.[98] This new blade incorporated a component that the operator could slide out to allow room for passage of an endotracheal tube or bronchoscope.[99]

Also in 1913, Henry H. Janeway (1873–1921) published results he had achieved using a laryngoscope he had recently developed.[100] An American anesthesiologist practicing at Bellevue Hospital in New York City, Janeway was of the opinion that direct intratracheal insufflation of volatile anesthetics would provide improved conditions for otolaryngologic surgery. With this in mind, he developed a laryngoscope designed for the sole purpose of tracheal intubation. Similar to Jackson's device, Janeway's instrument incorporated a distal light source. Unique, however, was the inclusion of batteries within the handle, a central notch in the blade for maintaining the tracheal tube in the midline of the oropharynx during intubation and a slight curve to the distal tip of the blade to help guide the tube through the glottis. The success of this design led to its subsequent use in other types of surgery. Janeway was thus instrumental in popularizing the widespread use of direct laryngoscopy and tracheal intubation in the practice of anesthesiology.[95]

In 1928 Arthur Ernest Guedel introduced the cuffed endotracheal tube, which allowed deep enough anesthesia that completely suppressed spontaneously respirations while the gas and oxygen were delivered via positive pressure ventilation controlled by the anesthesiologist.[101] Also important for the development of modern anesthesia are anesthesia machines. Only three years later Joseph W. Gale developed the technology where the anesthesiologist was able to ventilate only one lung at a time.[102] This allowed the development of thoracic surgery, which had previously been vexed by the pendelluft [103] problem in which the bad lung being operated on inflated with patient exhalation due to the loss of vacuum with the thorax being open to the atmosphere. Eventually by early 1980s double lumen endotracheal tubes made out of clear plastic enabled anesthesiologists to selectively ventilate one lung while using flexible fiberoptic bronchoscopy to block off the diseased lung and prevent cross contamination.[80] One early device, the copper kettle, was developed by Dr. Lucien E. Morris at the University of Wisconsin.[104][105]

Sodium thiopental, the first intravenous anesthetic, was synthesized in 1934 by Ernest H. Volwiler (1893–1992) and Donalee L. Tabern (1900–1974), working for Abbott Laboratories.[106] It was first used in humans on 8 March 1934 by Ralph M. Waters in an investigation of its properties, which were short-term anesthesia and surprisingly little analgesia. Three months later, John Silas Lundy started a clinical trial of thiopental at the Mayo Clinic at the request of Abbott Laboratories. Volwiler and Tabern were awarded U.S. Patent No. 2,153,729 in 1939 for the discovery of thiopental, and they were inducted into the National Inventors Hall of Fame in 1986.

In 1939, the search for a synthetic substitute for atropine culminated serendipitously in the discovery of meperidine, the first opiate with a structure altogether different from that of morphine.[107] This was followed in 1947 by the widespread introduction of methadone, another structurally unrelated compound with pharmacological properties similar to those of morphine.[108]

After World War I, further advances were made in the field of intratracheal anesthesia. Among these were those made by Sir Ivan Whiteside Magill (1888–1986). Working at the Queen's Hospital for Facial and Jaw Injuries in Sidcup with plastic surgeon Sir Harold Gillies (1882–1960) and anesthetist E. Stanley Rowbotham (1890–1979), Magill developed the technique of awake blind nasotracheal intubation.[109][110][111][112][113][114] Magill devised a new type of angulated forceps (the Magill forceps) that are still used today to facilitate nasotracheal intubation in a manner that is little changed from Magill's original technique.[115] Other devices invented by Magill include the Magill laryngoscope blade,[116] as well as several apparatuses for the administration of volatile anesthetic agents.[117][118][119] The Magill curve of an endotracheal tube is also named for Magill.

The first hospital anesthesia department was established at the Massachusetts General Hospital in 1936, under the leadership of Henry K. Beecher (1904–1976). Beecher, who received his training in surgery, had no previous experience in anesthesia.[120]

Although initially used to reduce the sequelae of spasticity associated with electroconvulsive therapy for psychiatric disease, curare found use in the operating rooms at Bellvue by E.M. Papper and Stuart Cullen in the 1940s using preparations made by Squibb.[121] This neuromuscular blockade permitted complete paralysis of the diaphragm and enabled control of ventilation via positive pressure ventilation.[80] Mechanical ventilation first became common place with the polio epidemics of the 1950s, most notably in Denmark where an outbreak in 1952 lead to the creation of critical care medicine out of anesthesia. At first anesthesiologists hesitated to bring the ventilator into the operating theater unless necessary, but by the 1960s it became standard operating room equipment.[80]

Sir Robert Macintosh (1897–1989) achieved significant advances in techniques for tracheal intubation when he introduced his new curved laryngoscope blade in 1943.[122] The Macintosh blade remains to this day the most widely used laryngoscope blade for orotracheal intubation.[123] In 1949, Macintosh published a case report describing the novel use of a gum elastic urinary catheter as an endotracheal tube introducer to facilitate difficult tracheal intubation.[124] Inspired by Macintosh's report, P. Hex Venn (who was at that time the anesthetic advisor to the British firm Eschmann Bros. & Walsh, Ltd.) set about developing an endotracheal tube introducer based on this concept. Venn's design was accepted in March 1973, and what became known as the Eschmann endotracheal tube introducer went into production later that year.[125] The material of Venn's design was different from that of a gum elastic bougie in that it had two layers: a core of tube woven from polyester threads and an outer resin layer. This provided more stiffness but maintained the flexibility and the slippery surface. Other differences were the length (the new introducer was 60 cm (24 in), which is much longer than the gum elastic bougie) and the presence of a 35° curved tip, permitting it to be steered around obstacles.[126][127]

For over a hundred years the mainstay of inhalational anesthetics remained ether with cyclopropane, which had been introduced in the 1930s. In 1956 halothane[128] was introduced which had the significant advantage of not being flammable. This reduced the risk of operating room fires. In the sixties the halogenated ethers superseded Halothane due to the rare, but significant side effects of cardiac arrhythmias and liver toxicity. The first two halogenated ethers were methoxyflurane and enflurane. These in turn were replaced by the current standards of isoflurane, sevoflurane, and desflurane in the eighties and nineties although methoxyflurane remains in use for prehospital anesthesia in Australia as Penthrox. Halothane remains in common place throughout much of the developing world.

Many new intravenous and inhalational anesthetics were developed and brought into clinical use during the second half of the 20th century. Paul Janssen (1926–2003), the founder of Janssen Pharmaceutica, is credited with the development of over 80 pharmaceutical compounds.[129] Janssen synthesized nearly all of the butyrophenone class of antipsychotic agents, beginning with haloperidol (1958) and droperidol (1961).[130] These agents were rapidly integrated into the practice of anesthesia.[131][132][133][134][135] In 1960, Janssen's team synthesized fentanyl, the first of the piperidinone-derived opioids.[136][137] Fentanyl was followed by sufentanil (1974),[138] alfentanil (1976),[139][140] carfentanil (1976),[141] and lofentanil (1980).[142] Janssen and his team also developed etomidate (1964),[143][144] a potent intravenous anesthetic induction agent.

The concept of using a fiberoptic endoscope for tracheal intubation was introduced by Peter Murphy, an English anesthetist, in 1967.[145] By the mid-1980s, the flexible fiberoptic bronchoscope had become an indispensable instrument within the pulmonology and anesthesia communities.[146]

21st century[edit]

A modern anaesthetic machine. This particular machine is a "Flow-I" model, manufactured by Maquet.

The "digital revolution" of the 21st century has brought newer technology to the art and science of tracheal intubation. Several manufacturers have developed video laryngoscopes which employ digital technology such as the CMOS active pixel sensor (APS) to generate a view of the glottis so that the trachea may be intubated. The Glidescope video laryngoscope is one example of such a device.[147][148]

Xenon has recently been approved in some jurisdictions as an anaesthetic agent which does not act as a greenhouse gas.[149]

See also[edit]


  1. ^ Kuntz, L; Vera, A (July–September 2005). "Transfer pricing in hospitals and efficiency of physicians: the case of anesthesia services". Health Care Management Review. 30 (3): 262–69. doi:10.1097/00004010-200507000-00010. PMID 16093892. S2CID 33859170.
  2. ^ a b c Haridas, Rajesh P. (1 November 2017). "Earliest English Definitions of Anaisthesia and Anaesthesia". Anesthesiology. 127 (5): 747–753. doi:10.1097/ALN.0000000000001764. PMID 28654424. S2CID 33004661.
  3. ^ ἀναισθησία. Liddell, Henry George; Scott, Robert; A Greek–English Lexicon at the Perseus Project
  4. ^ Small, MR (1962). Oliver Wendell Holmes. New York: Twayne Publishers. p. 55. ISBN 978-0-8084-0237-4. OCLC 273508. In a letter to dentist William T. G. Morton, Holmes wrote: "Everybody wants to have a hand in a great discovery. All I will do is to give a hint or two as to names—or the name—to be applied to the state produced and the agent. The state should, I think, be called 'Anaesthesia.' This signifies insensibility—more particularly ... to objects of touch."
  5. ^ Haridas, R. P. (July 2016). "The etymology and Use of the Word 'Anaesthesia': Oliver Wendell Holmes' Letter to W. T. G. Morton". Anaesthesia and Intensive Care. 44: 38–44. doi:10.1177/0310057X1604401S07. PMID 27456290.
  6. ^ Powell MA (2004). "9: Wine and the vine in ancient Mesopotamia: the cuneiform evidence". In McGovern PE, Fleming SJ, Katz SH (eds.). The Origins and Ancient History of Wine. Food and Nutrition in History and Anthropology. Vol. 11 (1 ed.). Amsterdam: Taylor & Francis. pp. 96–124. ISBN 9780203392836. ISSN 0275-5769. Retrieved 15 September 2010.
  7. ^ Evans, TC (1928). "The opium question, with special reference to Persia (book review)". Transactions of the Royal Society of Tropical Medicine and Hygiene. 21 (4): 339–340. doi:10.1016/S0035-9203(28)90031-0. Retrieved 18 September 2010. The earliest known mention of the poppy is in the language of the Sumerians, a non-Semitic people who descended from the uplands of Central Asia into Southern Mesopotamia....[permanent dead link]
  8. ^ Booth M (1996). "The discovery of dreams". Opium: A History. London: Simon & Schuster, Ltd. p. 15. ISBN 978-0-312-20667-3. Retrieved 18 September 2010.
  9. ^ Krikorian, AD (March 1975). "Were the opium poppy and opium known in the ancient Near East?". Journal of the History of Biology. 8 (1): 95–114. doi:10.1007/BF00129597. PMID 11609871. S2CID 23899398.
  10. ^ Kramer, SN (March 1954). "First pharmacopeia in man's recorded history". American Journal of Pharmacy and the Sciences Supporting Public Health. 126 (3): 76–84. ISSN 0002-9467. PMID 13148318.
  11. ^ Kramer SN, Tanaka H (March 1988). History Begins at Sumer: Thirty-Nine Firsts in Recorded History (3 ed.). Philadelphia: University of Pennsylvania Press. ISBN 978-0-8122-1276-1.
  12. ^ a b Terry CE, Pellens M (1928). "II: Development of the problem". The Opium Problem. New York: Bureau of Social Hygiene. p. 54. Retrieved 18 September 2010.
  13. ^ Sonnedecker G (1962). "Emergence of the Concept of Opiate Addiction". Journal Mondial de Pharmacie. 3: 275–290. ISSN 0021-8405.
  14. ^ a b c Anslinger HJ, Tompkins WF (1953). "The pattern of man's use of narcotic drugs". The Traffic in Narcotics. New York: Funk and Wagnalls. p. 1. ISBN 978-0-405-13567-5. Retrieved 18 September 2010.
  15. ^ Thompson RC (July 1926). "The Assyrian herbal: a monograph on the Assyrian vegetable drugs". Isis. 8 (3): 506–508. doi:10.1086/358424. JSTOR 223920. Thompson reinforces his view with the following quotation from a cuneiform tablet: 'Early in the morning old women, boys, and girls collect the juice, scraping it off the notches (of the poppy-capsule) with a small iron blade, and place it within a clay receptacle.'
  16. ^ a b Ludwig Christian Stern (1889). Ebers G (ed.). Papyrus Ebers (in German). Vol. 2 (1 ed.). Leipzig: Bei S. Hirzel. OCLC 14785083. Retrieved 18 September 2010.
  17. ^ Pahor, AL (August 1992). "Ear, nose and throat in ancient Egypt: Part I". The Journal of Laryngology & Otology. 106 (8): 677–87. doi:10.1017/S0022215100120560. PMID 1402355. S2CID 35712860.
  18. ^ Sullivan, R (August 1996). "The identity and work of the ancient Egyptian surgeon". Journal of the Royal Society of Medicine. 89 (8): 467–73. doi:10.1177/014107689608900813. PMC 1295891. PMID 8795503.
  19. ^ Ebbell B (1937). The Papyrus Ebers: The greatest Egyptian medical document. Copenhagen: Levin & Munksgaard. Archived from the original on 26 February 2005. Retrieved 18 September 2010.
  20. ^ Bisset NG, Bruhn JG, Curto S, Halmsted B, Nymen U, Zink MH (January 1994). "Was opium known in 18th Dynasty ancient Egypt? An examination of materials from the tomb of the chief royal architect Kha". Journal of Ethnopharmacology. 41 (1–2): 99–114. doi:10.1016/0378-8741(94)90064-7. PMID 8170167.
  21. ^ Kritikos PG, Papadaki SP (1967). "The history of the poppy and of opium and their expansion in antiquity in the eastern Mediterranean area". Bulletin on Narcotics. 19 (3): 17–38. ISSN 0007-523X. Archived from the original on 28 July 2011. Retrieved 18 September 2010.
  22. ^ Sushruta (1907). "Introduction". In Kaviraj Kunja Lal Bhishagratna (ed.). Sushruta Samhita, Volume1: Sutrasthanam. Calcutta: Kaviraj Kunja Lal Bhishagratna. pp. iv. Retrieved 13 September 2010.
  23. ^ Dwarakanath SC (1965). "Use of opium and cannabis in the traditional systems of medicine in India". Bulletin on Narcotics. 17 (1): 15–9. ISSN 0007-523X. Archived from the original on 28 July 2011. Retrieved 27 September 2010.
  24. ^ Fort J (1965). "Giver of delight or Liberator of sin: Drug use and "addiction" in Asia". Bulletin on Narcotics. 17 (3): 1–11. ISSN 0007-523X. Archived from the original on 28 July 2011. Retrieved 27 September 2010.
  25. ^ a b c Gordon BL (1949). Medicine throughout Antiquity (1 ed.). Philadelphia: F.A. Davis Company. pp. 358, 379, 385, 387. ISBN 9780598609977. OCLC 1574261. Retrieved 14 September 2010. Pien Chiao (ca. 300 BC) used general anesthesia for surgical procedures. It is recorded that he gave two men, named "Lu" and "Chao", a toxic drink which rendered them unconscious for three days, during which time he performed a gastrotomy upon them
  26. ^ Giles L (transl.) (1912). Taoist teachings from the book of Lieh-Tzŭ, translated from the Chinese, with introduction and notes, by Lionel Giles (Wisdom of the East series). London: John Murray. Retrieved 14 September 2010.
  27. ^ Salguero, CP (February 2009). "The Buddhist medicine king in literary context: reconsidering an early medieval example of Indian influence on Chinese medicine and surgery". History of Religions. 48 (3): 183–210. doi:10.1086/598230. ISSN 0018-2710. S2CID 162211011.
  28. ^ a b c d e Chu NS (December 2004). "Legendary Hwa Tuo's surgery under general anesthesia in the second century China" (PDF). Acta Neurologica Taiwanica (in Chinese). 13 (4): 211–6. ISSN 1028-768X. PMID 15666698. Archived from the original (PDF) on 26 February 2012. Retrieved 18 September 2010.
  29. ^ a b Giles HA (1898). A Chinese Biographical Dictionary. London: Bernard Quaritch. pp. 323–4, 762–3. ISBN 9780896440104. Retrieved 14 September 2010. If a disease seemed beyond the reach of needles and cautery, he operated, giving his patients a dose of hashish which rendered them unconscious.
  30. ^ a b Giles L (transl.) (1948). Cranmer-Byng JL (ed.). A Gallery of Chinese immortals: selected biographies, translated from Chinese sources by Lionel Giles (Wisdom of the East series) (1 ed.). London: John Murray. Retrieved 14 September 2010. The well-attested fact that Hua T'o made use of an anaesthetic for surgical operations over 1,600 years before Sir James Simpson certainly places him to our eyes on a pinnacle of fame....
  31. ^ a b Chen J (August 2008). "A Brief Biography of Hua Tuo". Acupuncture Today. 9 (8). ISSN 1526-7784.
  32. ^ Wang Z; Ping C (1999). "Well-known medical scientists: Hua Tuo". In Ping C (ed.). History and Development of Traditional Chinese Medicine. Vol. 1. Beijing: Science Press. pp. 88–93. ISBN 978-7-03-006567-4. Retrieved 13 September 2010.
  33. ^ Fu LK (August 2002). "Hua Tuo, the Chinese god of surgery". Journal of Medical Biography. 10 (3): 160–6. doi:10.1177/096777200201000310. PMID 12114950. S2CID 31655903. Archived from the original on 19 July 2009. Retrieved 13 September 2010.
  34. ^ Huang Ti Nei Ching Su Wen: The Yellow Emperor's Classic of Internal Medicine. Translated by Ilza Veith. Berkeley, Los Angeles: University of California Press. 1972. p. 265. ISBN 978-0-520-02158-7.
  35. ^ a b Ch'en S (2000). "The Biography of Hua-t'o from the History of the Three Kingdoms". In Mair VH (ed.). The shorter Columbia anthology of traditional Chinese literature. Vol. Part III: Prose. New York: Columbia University Press. pp. 441–9. ISBN 978-0-231-11998-6. Retrieved 13 September 2010.
  36. ^ Lu GD; Needham J (2002). "Acupuncture and major surgery". Celestial lancets: a history and rationale of acupuncture and moxa. London: RoutledgeCurzon. pp. 218–30. ISBN 978-0-7007-1458-2. Retrieved 13 September 2010.
  37. ^ Wai, FK (2004). "On Hua Tuo's Position in the History of Chinese Medicine". The American Journal of Chinese Medicine. 32 (2): 313–20. doi:10.1142/S0192415X04001965. PMID 15315268.
  38. ^ Carroll E. (1997). "Coca: the plant and its use" (PDF). In Robert C. Petersen; Richard C. Stillman (eds.). Cocaine: 1977. United States Department of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration. p. 35. Archived from the original (PDF) on 4 November 2014. Retrieved 3 November 2014.
  39. ^ Peterson, RC (1997). "History of Cocaine" (PDF). In Robert C. Petersen; Richard C. Stillman (eds.). Cocaine: 1977. United States Department of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration. pp. 17–32. Archived from the original (PDF) on 4 November 2014. Retrieved 16 September 2010.
  40. ^ Rivera MA; Aufderheide AC; Cartmell LW; Torres CM; Langsjoen O (December 2005). "Antiquity of coca-leaf chewing in the south central Andes: a 3,000 year archaeological record of coca-leaf chewing from northern Chile". Journal of Psychoactive Drugs. 37 (4): 455–8. doi:10.1080/02791072.2005.10399820. PMID 16480174. S2CID 28661721.
  41. ^ Skinner, P (2008). "Unani-tibbi". In Laurie J. Fundukian (ed.). The Gale Encyclopedia of Alternative Medicine (3rd ed.). Farmington Hills, Michigan: Gale Cengage. ISBN 978-1-4144-4872-5. Retrieved 13 September 2010.
  42. ^ Ajram K (1992). Miracle of Islamic Science (1 ed.). Vernon Hills, IL: Knowledge House Publishers. pp. Appendix B. ISBN 978-0-911119-43-5. Retrieved 18 September 2010.
  43. ^ Hunke S (1960). Allahs Sonne über dem Abendland: unser arabisches Erbe (in German) (2 ed.). Stuttgart: Deutsche Verlags-Anstalt. pp. 279–80. ISBN 978-3-596-23543-8. Retrieved 13 September 2010. The science of medicine has gained a great and extremely important discovery and that is the use of general anaesthetics for surgical operations, and how unique, efficient, and merciful for those who tried it the Muslim anaesthetic was. It was quite different from the drinks the Indians, Romans and Greeks were forcing their patients to have for relief of pain. There had been some allegations to credit this discovery to an Italian or to an Alexandrian, but the truth is and history proves that, the art of using the anaesthetic sponge is a pure Muslim technique, which was not known before. The sponge used to be dipped and left in a mixture prepared from cannabis, opium, hyoscyamus, and a plant called Zoan.
  44. ^ Kritikos PG, Papadaki SP (1967). "The History of the Poppy and of Opium and Their Expansion in Antiquity in the Eastern Mediterranean Area". Bulletin on Narcotics. 19 (4): 5–10. ISSN 0007-523X.
  45. ^ a b c d e Carter, Anthony J. (18 December 1999). "Dwale: an anaesthetic from old England". BMJ. 319 (7225): 1623–1626. doi:10.1136/bmj.319.7225.1623. PMC 1127089. PMID 10600971.
  46. ^ Gravenstein JS (November–December 1965). "Paracelsus and his contributions to anesthesia". Anesthesiology. 26 (6): 805–11. doi:10.1097/00000542-196511000-00016. PMID 5320896.
  47. ^ Frobenius, AS (1 January 1729). "An Account of a Spiritus Vini Æthereus, Together with Several Experiments Tried Therewith". Philosophical Transactions. 36 (413): 283–9. doi:10.1098/rstl.1729.0045. S2CID 186207852.
  48. ^ Mortimer, C; Mortimer, C. (1 January 1739). "Abstracts of the Original Papers Communicated to the Royal Society by Sigismond Augustus Frobenius, M. D. concerning His Spiritus Vini Aethereus: Collected by C. Mortimer, M. D. Secr. R. S". Philosophical Transactions. 41 (461): 864–70. Bibcode:1739RSPT...41..864F. doi:10.1098/rstl.1739.0161.
  49. ^ Priestley J (1775). Experiments and Observations on Different Kinds of Air. Vol. 1 (2 ed.). London: J. Johnson. pp. 108–29, 203–29. Retrieved 13 September 2010.
  50. ^ Levere, TH (July 1977). "Dr. Thomas Beddoes and the establishment of his Pneumatic Institution: a tale of three presidents". Notes and Records of the Royal Society. 32 (1): 41–9. doi:10.1098/rsnr.1977.0005. JSTOR 531764. PMID 11615622. S2CID 27322059.
  51. ^ Sneader W (2005). "Chapter 8: Systematic medicine". Drug discovery: a history. Chichester, England: John Wiley and Sons. pp. 78–9. ISBN 978-0-471-89980-8. Retrieved 13 September 2010.
  52. ^ Davy H (1800). Researches, chemical and philosophical–chiefly concerning nitrous oxide or dephlogisticated nitrous air, and its respiration. Bristol: Biggs and Cottle. Retrieved 18 September 2010.
  53. ^ Arashiro Toshiaki, Ryukyu-Okinawa Rekishi Jinbutusuden OkinawaJijishuppan, 12006. pp. 66–68
  54. ^ a b c Izuo, M (November 2004). "Medical history: Seishū Hanaoka and his success in breast cancer surgery under general anesthesia two hundred years ago". Breast Cancer. 11 (4): 319–24. doi:10.1007/BF02968037. PMID 15604985. S2CID 43428862.
  55. ^ Ogata T (November 1973). "Seishu Hanaoka and his anaesthesiology and surgery". Anaesthesia. 28 (6): 645–52. doi:10.1111/j.1365-2044.1973.tb00549.x. PMID 4586362. S2CID 31352880.
  56. ^ a b Hyodo M (1992). "Doctor S. Hanaoka, the world's-first success in providing general anesthesia". In Hyodo M, Oyama T, Swerdlow M (eds.). The Pain Clinic IV: proceedings of the fourth international symposium. Utrecht, Netherlands: VSP. pp. 3–12. ISBN 978-90-6764-147-0. Retrieved 13 September 2010.
  57. ^ a b van D., JH (2010). "Chosen-asagao and the recipe for Hanaoka's anesthetic 'tsusensan'". Brighton, UK: BLTC Research. Retrieved 13 September 2010.
  58. ^ Matsuki A (December 1999). "A bibliographical study on Shutei Nakagawa's "Mayaku-ko" (a collection of anesthetics and analgesics)--a comparism of four manuscripts". Nihon Ishigaku Zasshi (in Japanese). 45 (4): 585–99. ISSN 0549-3323. PMID 11624281. Archived from the original on 13 March 2012. Retrieved 13 September 2010.
  59. ^ Perrin, N (1979). Giving up the gun: Japan's reversion to the sword, 1543–1879. Boston: David R. Godine. p. 86. ISBN 978-0-87923-773-8. Retrieved 13 September 2010.
  60. ^ a b Matsuki A (September 2000). "New studies on the history of anesthesiology—a new study on Seishū Hanaoka's "Nyugan Ckiken Roku" (a surgical experience with breast cancer)". Masui. 49 (9): 1038–43. ISSN 0021-4892. PMID 11025965. Retrieved 13 September 2010.
  61. ^ Tominaga, T (30 December 1994). "Presidential address: Newly established Japanese breast cancer society and the future". Breast Cancer. 1 (2): 69–78. doi:10.1007/BF02967035. PMID 11091513. S2CID 27050128.
  62. ^ Matsuki A (March 2002). "A Study on Seishu Hanaoka's Nyugan Seimei Roku (Scroll of Diseases): A Name List of Breast Cancer Patients". Nihon Ishigaku Zasshi (in Japanese). 48 (1): 53–65. ISSN 0549-3323. PMID 12152628. Archived from the original on 13 March 2012. Retrieved 13 September 2010.
  63. ^ Meyer, K (2004). "Dem Morphin auf der Spur". Pharmazeutischen Zeitung (in German). GOVI-Verlag. Retrieved 12 June 2012.
  64. ^ Serturner FWA (1806). J. Pharm. f. Arzte. Apoth. Chem. 14, 47–93.
  65. ^ Serturner FWA (1817). Gilbert's Annalen der Physik 25, 56–89.
  66. ^ Desai SP, Desai MS, Pandav CS (2007). "The Discovery of Modern Anaesthesia–Contributions of Davy, Clarke, Long, Wells, and Morton". Indian Journal of Anaesthesia. 51 (6): 472–8. ISSN 0019-5049.
  67. ^ Sims JM (1877). "The Discovery of Anaesthesia". Virginia Medical Monthly. 4 (2): 81–100.
  68. ^ a b Lyman HM (1881). "History of anaesthesia". Artificial anaesthesia and anaesthetics. New York: William Wood and Company. p. 6. Retrieved 13 September 2010.
  69. ^ Lyman HM (September 1886). "The discovery of anesthesia". Virginia Medical Monthly. 13 (6): 369–92. Retrieved 13 September 2010.
  70. ^ Richmond PA (1950). "Was William E. Clarke of Rochester the first American to use ether for surgical anesthesia?". Genesee County Scrapbook of the Rochester Historical Society. 1: 11–3.
  71. ^ Stone RF (1898). Stone RF (ed.). Biography of Eminent American Physicians and Surgeons (2 ed.). Indianapolis: CE Hollenbeck. p. 89. Retrieved 13 September 2010.
  72. ^ a b Long CW (December 1849). "An account of the first use of Sulphuric Ether by Inhalation as an Anaesthetic in Surgical Operations". Southern Medical and Surgical Journal. 5: 705–13. reprinted in Long, C. W. (December 1991). "An account of the first use of Sulphuric Ether by Inhalation as an Anaesthetic in Surgical Operations". Survey of Anesthesiology. 35 (6): 375. doi:10.1097/00132586-199112000-00049.
  73. ^ a b c Snow, Stephanie (2005). Operations without pain: the practice and science of anaesthesia in Victorian Britain. Springer-Verlag. ISBN 978-0-333-71492-8.
  74. ^ Wells, H (1847). A History of the Discovery of the Application of Nitrous Oxide Gas, Ether, and Other Vapors to Surgical Operations. Hartford: J. Gaylord Wells. Retrieved 13 September 2010. Horace Wells.
  75. ^ a b Morton, WTG (1847). Remarks on the Proper Mode of Administering Sulphuric Ether by Inhalation (PDF). Boston: Button and Wentworth. OCLC 14825070. Retrieved 13 September 2010.
  76. ^ a b Fenster, JM (2001). Ether Day: The Strange Tale of America's Greatest Medical Discovery and the Haunted Men Who Made It. New York: HarperCollins. ISBN 978-0-06-019523-6.
  77. ^ Jackson CT (1861). A Manual of Etherization: Containing Directions for the Employment of Ether. Boston: J.B. Mansfield. Retrieved 13 September 2010.
  78. ^ Northen WJ; Graves JT (1910). Men of Mark in Georgia: A Complete and Elaborate History of the State from Its Settlement to the Present Time, Chiefly Told in Biographies and Autobiographies of the Most Eminent Men of Each Period of Georgia's Progress and Development. Vol. 2. Atlanta, Georgia: A.B. Caldwell. pp. 131–136.
  79. ^ Caton, D (2000). "John Snow's practice of obstetric anesthesia". Anesthesiology: The Journal of the American Society of Anesthesiologists. 92 (1): 247–52. doi:10.1097/00000542-200001000-00037. PMID 10638922. S2CID 8117674.
  80. ^ a b c d Brodsky, J; Lemmens, H (2007). "The history of anesthesia for thoracic surgery". Minerva Anestesiologica. 73 (10): 513–24. PMID 17380101.
  81. ^ Wawersik, J (May–June 1991). "History of anesthesia in Germany". Journal of Clinical Anesthesia. 3 (3): 235–244. doi:10.1016/0952-8180(91)90167-L. PMID 1878238. Retrieved 13 September 2010.
  82. ^ Bain, JA; Spoerel, WE (November 1964). "Observation on the use of cuffed tracheostomy tubes (with particular reference to the James tube)". Canadian Anaesthetists' Society Journal. 11 (6): 598–608. doi:10.1007/BF03004104. PMID 14232175.
  83. ^ Trendelenburg, F (1871). "Beiträge zu den Operationen an den Luftwegen" [Contributions to airways surgery]. Archiv für Klinische Chirurgie (in German). 12: 112–33.
  84. ^ Hargrave, R (June 1934). "Endotracheal Anæsthesia in Surgery of the Head and Neck". Canadian Medical Association Journal. 30 (6): 633–7. PMC 403396. PMID 20319535.
  85. ^ Reutsch, Y; Boni, T; Borgeat, A (2001). "From cocaine to ropivacaine: the history of local anesthetic drugs". Current Topics in Medicinal Chemistry. 1 (3): 175–182. doi:10.2174/1568026013395335. PMID 11895133.
  86. ^ Niemann, A (1860). "Uber eine Neue Organische Base in den Cocablättern [thesis]". Göttingen. {{cite journal}}: Cite journal requires |journal= (help)
  87. ^ Macewen, W (July 1880). "General Observations on the Introduction of Tracheal Tubes by the Mouth, Instead of Performing Tracheotomy or Laryngotomy". British Medical Journal. 2 (1021): 122–4. doi:10.1136/bmj.2.1021.122. PMC 2241154. PMID 20749630.
  88. ^ Macewen, W (July 1880). "Clinical Observations on the Introduction of Tracheal Tubes by the Mouth, Instead of Performing Tracheotomy or Laryngotomy". British Medical Journal. 2 (1022): 163–5. doi:10.1136/bmj.2.1022.163. PMC 2241109. PMID 20749636.
  89. ^ Macmillan, M (May 2010). "William Macewen [1848–1924]". Journal of Neurology. 257 (5): 858–9. doi:10.1007/s00415-010-5524-5. PMID 20306068.
  90. ^ García, M (24 May 1855). "Observations on the Human Voice". Proceedings of the Royal Society of London. 7 (60): 399–410. Bibcode:1854RSPS....7..399G. doi:10.1098/rspl.1854.0094. PMC 5180321. PMID 30163547. Retrieved 13 September 2010.
  91. ^ Hack, W (1878). "Über die mechanische Behandlung der Larynxstenosen" [On the mechanical treatment of laryngeal stenosis]. Sammlung Klinischer Vorträge (in German). 152: 52–75.
  92. ^ Hack, W (March 1878). "Über einen fall endolaryngealer exstirpation eines polypen der vorderen commissur während der inspirationspause". Berliner Klinische Wochenschrift (in German): 135–7. Retrieved 13 September 2010.
  93. ^ Hirsch, NP; Smith, GB; Hirsch, PO (January 1986). "Alfred Kirstein. Pioneer of direct laryngoscopy". Anaesthesia. 41 (1): 42–5. doi:10.1111/j.1365-2044.1986.tb12702.x. PMID 3511764. S2CID 12259652.
  94. ^ Mackenzie, M (1888). The case of Emperor Frederick III.: full official reports by the German physicians and by Sir Morell Mackenzie. New York: Edgar S. Werner. p. 276. Retrieved 13 September 2010.
  95. ^ a b Burkle, CM; Zepeda, FA; Bacon, DR; Rose, SH (April 2004). "A Historical Perspective on Use of the Laryngoscope as a Tool in Anesthesiology". Anesthesiology. 100 (4): 1003–6. doi:10.1097/00000542-200404000-00034. PMID 15087639. S2CID 36279277.
  96. ^ Fischer EH; Mering J (March 1903). "Ueber eine neue Klasse von Schlafmitteln". Die Therapie der Gegenwart (in German). 5: 97–101. Retrieved 13 September 2010.
  97. ^ Jackson, C (1913). "The technique of insertion of intratracheal insufflation tubes". Surgery, Gynecology & Obstetrics. 17: 507–9. Reprinted in Jackson, Chevalier (May 1996). "The technique of insertion of intratracheal insufflation tubes". Pediatric Anesthesia. 6 (3): 230. doi:10.1111/j.1460-9592.1996.tb00434.x. S2CID 72582327.
  98. ^ Zeitels, S (March 1998). "Chevalier Jackson's contributions to direct laryngoscopy". Journal of Voice. 12 (1): 1–6. doi:10.1016/S0892-1997(98)80069-6. PMID 9619973.
  99. ^ Jackson, C (1922). "I: Instrumentarium" (PDF). A manual of peroral endoscopy and laryngeal surgery. Philadelphia: W.B. Saunders. pp. 17–52. ISBN 978-1-4326-6305-6. Retrieved 13 September 2010.
  100. ^ Janeway, HH (November 1913). "Intra-tracheal anesthesia from the standpoint of the nose, throat and oral surgeon with a description of a new instrument for catheterizing the trachea". The Laryngoscope. 23 (11): 1082–90. doi:10.1288/00005537-191311000-00009. S2CID 71549386.
  101. ^ Guedel, A; Waters, R (1928). "A new intratracheal catheter". Anesthesia and Analgesia. 7 (4): 238–239. doi:10.1213/00000539-192801000-00089.
  102. ^ Gale, J; Waters, R (1932). "Closed endobronchial anesthesia in thoracic surgery: preliminary report". Anesthesia and Analgesia. 11 (6): 283–288. doi:10.1213/00000539-193201000-00049.
  103. ^ Greenblatt, E; Butler, J; Venegas, J; Winkler, T (2014). "Pendelluft in the bronchial tree". American Journal of Physiology. Heart and Circulatory Physiology. 117 (9): 979–988. doi:10.1152/japplphysiol.00466.2014. PMC 4217048. PMID 25170072.
  104. ^ Morris, L (1952). "A new vaporizer for liquid anesthetic agents". Anesthesiology: The Journal of the American Society of Anesthesiologists. 13 (6): 587–593. doi:10.1097/00000542-195211000-00003. PMID 12986220. S2CID 26847436.
  105. ^ Morris, L (2006). "Copper kettle revisited". Anesthesiology: The Journal of the American Society of Anesthesiologists. 104 (4): 881–884. doi:10.1097/00000542-200604000-00034. PMID 16571985. S2CID 72593495.
  106. ^ Tabern, DL; Volwiler, EH (October 1935). "Sulfur-containing barbiturate hypnotics". Journal of the American Chemical Society. 57 (10): 1961–3. doi:10.1021/ja01313a062.
  107. ^ Eisleb, 0. & Schaumann, 0. (1939) Deutsche Medizinische Wochenschrift 65, 967–968.
  108. ^ Scott C. C., Chen K. K. (1946). "The action of 1,1-diphenyl-1 (Dimethylaminoisopropyl) butanone-2, a potent analgesic agent". Journal of Pharmacology and Experimental Therapeutics. 87: 63–71. PMID 20986681.
  109. ^ Rowbotham, ES; Magill, I (1921). "Anæsthetics in the Plastic Surgery of the Face and Jaws". Proceedings of the Royal Society of Medicine. 14 (Sect Anaesth): 17–27. doi:10.1177/003591572101401402. PMC 2152821. PMID 19981941.
  110. ^ Magill, I (14 July 1923). "The provision for expiration in endotracheal insufflations anaesthesia". The Lancet. 202 (5211): 68–9. doi:10.1016/S0140-6736(01)37756-5.
  111. ^ Magill, I (December 1928). "Endotracheal Anæsthesia". Proceedings of the Royal Society of Medicine. 22 (2): 85–8. PMC 2101959. PMID 19986772.
  112. ^ Magill, I (November 1930). "Technique in Endotracheal Anaesthesia". British Medical Journal. 2 (1243): 817–9. doi:10.1136/bmj.2.1243.817-a. PMC 2451624. PMID 20775829.
  113. ^ Thomas, KB (July–August 1978). "Sir Ivan Whiteside Magill, KCVO, DSc, MB, BCh, BAO, FRCS, FFARCS (Hon), FFARCSI (Hon), DA. A review of his publications and other references to his life and work". Anaesthesia. 33 (7): 628–34. doi:10.1111/j.1365-2044.1978.tb08426.x. PMID 356665. S2CID 28730699.
  114. ^ McLachlan, G (September 2008). "Sir Ivan Magill KCVO, DSc, MB, BCh, BAO, FRCS, FFARCS (Hon), FFARCSI (Hon), DA, (1888–1986)". Ulster Medical Journal. 77 (3): 146–52. PMC 2604469. PMID 18956794.
  115. ^ Magill, I (October 1920). "Appliances and Preparations". British Medical Journal. 2 (3122): 670. doi:10.1136/bmj.2.571.670. PMC 2338485. PMID 20770050.
  116. ^ Magill, I (6 March 1926). "An improved laryngoscope for anaesthetists". The Lancet. 207 (5349): 500. doi:10.1016/S0140-6736(01)17109-6.
  117. ^ Magill, I (30 April 1921). "A Portable Apparatus for Tracheal Insufflation Anaesthesia". The Lancet. 197 (5096): 918. doi:10.1016/S0140-6736(00)55592-5.
  118. ^ Magill, I (11 June 1921). "Warming Ether Vapour for Inhalation". The Lancet. 197 (5102): 1270. doi:10.1016/S0140-6736(01)24908-3.
  119. ^ Magill, I (4 August 1923). "An apparatus for the administration of nitrous oxide, oxygen, and ether". The Lancet. 202 (5214): 228. doi:10.1016/S0140-6736(01)22460-X.
  120. ^ Gravenstein, Joachim (January 1998). "Henry K. Beecher: The Introduction of Anesthesia into the University". Anesthesiology. 88 (1): 245–253. doi:10.1097/00000542-199801000-00033. PMID 9447878. S2CID 5944101.
  121. ^ Betcher, A (1977). "The civilizing of curare: a history of its development and introduction into anesthesiology". Anesthesia & Analgesia. 56 (2): 305–319. doi:10.1213/00000539-197703000-00032. PMID 322548.
  122. ^ Macintosh, RR (13 February 1943). "A new laryngoscope". The Lancet. 241 (6233): 205. doi:10.1016/S0140-6736(00)89390-3.
  123. ^ Scott, J; Baker, PA (July 2009). "How did the Macintosh laryngoscope become so popular?". Pediatric Anesthesia. 19 (Suppl 1): 24–9. doi:10.1111/j.1460-9592.2009.03026.x. PMID 19572841. S2CID 6345531.
  124. ^ Macintosh, RR (1 January 1949). "Marxist Genetics". British Medical Journal. 1 (4591): 26–28. doi:10.1136/bmj.1.4591.26-b. PMC 2049235.
  125. ^ Venn, PH (March 1993). "The gum elastic bougie". Anaesthesia. 48 (3): 274–5. doi:10.1111/j.1365-2044.1993.tb06936.X. S2CID 56666422.
  126. ^ Viswanathan, S; Campbell, C; Wood, DG; Riopelle, JM; Naraghi, M (November–December 1992). "The Eschmann Tracheal Tube Introducer. (Gum elastic bougie)". Anesthesiology Review. 19 (6): 29–34. PMID 10148170.
  127. ^ Henderson, JJ (January 2003). "Development of the 'gum-elastic bougie'". Anaesthesia. 58 (1): 103–4. doi:10.1046/j.1365-2044.2003.296828.x. PMID 12492697. S2CID 34113322.
  128. ^ Raventos, J; Goodall, R (1956). "The Action of Fluothane-A New Volatile Anaesthetic". British Journal of Pharmacology and Chemotherapy. 11 (4): 394–410. doi:10.1111/j.1476-5381.1956.tb00007.x. PMC 1510559. PMID 13383118.
  129. ^ Stanley, TH; Egan, TD; Van Aken, H (February 2008). "A Tribute to Dr. Paul A. J. Janssen: Entrepreneur Extraordinaire, Innovative Scientist, and Significant Contributor to Anesthesiology". Anesthesia & Analgesia. 106 (2): 451–62. doi:10.1213/ane.0b013e3181605add. PMID 18227300. S2CID 20490363.
  130. ^ Janssen, PA; Niemegeers, CJ; Schellekens, KH; Verbruggen, FJ; Van Nueten, JM (March 1963). "The pharmacology of dehydrobenzperidol, a new potent and short acting neuroleptic agent chemically related to Haloperidol". Arzneimittel-Forschung. 13: 205–11. PMID 13957425.
  131. ^ de Castro J, Mundeleer P (1959). "Anesthésie sans barbituriques: la neuroleptanalgésie". Anesthésie, Analgésie, Réanimation (in French). 16: 1022–56. ISSN 0003-3014.
  132. ^ Nilsson E, Janssen PA (1961). "Neurolept-analgesia: an alternative to general anesthesia". Acta Anaesthesiologica Scandinavica. 5 (2): 73–84. doi:10.1111/j.1399-6576.1961.tb00085.x. ISSN 0001-5172. PMID 13729171. S2CID 44479255.
  133. ^ Aubry, U; Carignan, G; Chare-Tee, D; Keeri-Szanto, M; Lavallee, JP (May 1966). "Neuroleptanalgesia with fentanyl-droperidol: An appreciation based on more than 1000 anaesthetics for major surgery". Canadian Anaesthetists' Society Journal. 13 (3): 263–71. doi:10.1007/BF03003549. PMID 5961929.
  134. ^ Corssen, G; Domino, EF; Sweet, RB (November–December 1964). "Neuroleptanalgesia and Anesthesia". Anesthesia & Analgesia. 43 (6): 748–63. doi:10.1213/00000539-196411000-00028. PMID 14230731. S2CID 30419023.
  135. ^ Reyes JC, Wier GT, Moss NH, Romero JB, Hill R (September 1969). "Neuroleptanalgesia and anesthesia: Experiences in 60 poor risk geriatric patients". South Dakota Journal of Medicine. 22 (9): 31–3. PMID 5259472.
  136. ^ J., PA; Eddy, NB (February 1960). "Compounds Related to Pethidine--IV. New General Chemical Methods of Increasing the Analgesic Activity of Pethidine". Journal of Medicinal Chemistry. 2 (1): 31–45. doi:10.1021/jm50008a003. PMID 14406754.
  137. ^ Janssen, PA; Niemegeers, CJ; Dony, JG (1963). "The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawal reflex in rats" (PDF). Arzneimittel-Forschung. 13: 502–7. PMID 13957426.
  138. ^ Niemegeers, CJ; Schellekens, KH; Van Bever, WF; Janssen, PA (1976). "Sufentanil, a very potent and extremely safe intravenous morphine-like compound in mice, rats and dogs". Arzneimittel-Forschung. 26 (8): 1551–6. PMID 12772.
  139. ^ Spierdijk J, van Kleef J, Nauta J, Stanley TH, de Lange S (1980). "Alfentanil: a new narcotic induction agent". Anesthesiology. 53: S32. doi:10.1097/00000542-198009001-00032.
  140. ^ Niemegeers CJ, Janssen PA (1981). "Alfentanil (R39209)-a particularly short acting intravenous narcotic analgesic in rats". Drug Development Research. 1: 830–8. doi:10.1002/ddr.430010111. ISSN 0272-4391. S2CID 84794527.
  141. ^ De Vos, V (22 July 1978). "Immobilisation of free-ranging wild animals using a new drug". Veterinary Record. 103 (4): 64–8. doi:10.1136/vr.103.4.64. PMID 685103. S2CID 36314586.
  142. ^ Laduron, P; Janssen, PF (August 1982). "Axoplasmic transport and possible recycling of opiate receptors labelled with 3H-lofentanil". Life Sciences. 31 (5): 457–62. doi:10.1016/0024-3205(82)90331-9. PMID 6182434.
  143. ^ Doenicke A, Kugler J, Penzel G, Laub M, Kalmar L, Kilian I, Bezecny H (August 1973). "[Cerebral function under etomidate, a new non-barbiturate i.v. hypnotic]". Der Anaesthesist (in German). 22 (8): 353–66. ISSN 0003-2417. PMID 4584133. Archived from the original on 20 July 2011. Retrieved 27 September 2010.
  144. ^ Morgan, M; Lumley, Jean; Whitwam, J.G. (26 April 1975). "Etomidate, a New Water-Soluble Non-barbiturate Intravenous Induction Agent". The Lancet. 305 (7913): 955–6. doi:10.1016/S0140-6736(75)92011-5. PMID 48126. S2CID 205992130.
  145. ^ Murphy, P (July 1967). "A fibre-optic endoscope used for nasal intubation". Anaesthesia. 22 (3): 489–91. doi:10.1111/j.1365-2044.1967.tb02771.x. PMID 4951601. S2CID 33586314.
  146. ^ Wheeler M and Ovassapian A (2007). "Chapter 18: Fiberoptic endoscopy-aided technique". In Benumof, JL (ed.). Benumof's Airway Management: Principles and Practice (2nd ed.). Philadelphia: Mosby-Elsevier. p. 423. ISBN 978-0-323-02233-0. Retrieved 13 September 2010.
  147. ^ Agrò, F; Barzoi, G; Montecchia, F (May 2003). "Tracheal intubation using a Macintosh laryngoscope or a GlideScope in 15 patients with cervical spine immobilization". British Journal of Anaesthesia. 90 (5): 705–6. doi:10.1093/bja/aeg560. PMID 12697606.
  148. ^ Cooper, RM; Pacey, JA; Bishop, MJ; McCluskey, SA (February 2005). "Early clinical experience with a new videolaryngoscope (GlideScope) in 728 patients". Canadian Journal of Anesthesia. 52 (2): 191–8. doi:10.1007/BF03027728. PMID 15684262.
  149. ^ Tonner, PH (August 2006). "Xenon: one small step for anaesthesia...? (editorial review)". Current Opinion in Anesthesiology. 19 (4): 382–4. doi:10.1097/01.aco.0000236136.85356.13. PMID 16829718. S2CID 2989630.

Further reading[edit]

External links[edit]