Lipopolysaccharide binding protein

LBP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4M4D
Identifiers
Aliases	LBP, BPIFD2, lipopolysaccharide binding protein
External IDs	OMIM: 151990; MGI: 1098776; HomoloGene: 3055; GeneCards: LBP; OMA:LBP - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	38,377,013 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	158,174,772 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; testicle; ; tibialis anterior muscle; ; gastrocnemius muscle; ; muscle of thigh; ; appendix; ; deltoid muscle; ; subcutaneous adipose tissue; ; glutes; ; right lobe of thyroid gland;
	Top expressed in
	gastrula; ; choroid plexus of fourth ventricle; ; decidua; ; Epithelium of choroid plexus; ; lumbar spinal ganglion; ; ankle; ; ankle joint; ; stroma of bone marrow; ; left lobe of liver; ; uterus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	lipoteichoic acid binding; protein binding; lipid binding; signaling receptor binding; lipopolysaccharide binding; lipopeptide binding;
Cellular component	membrane; extracellular exosome; extracellular region; cell surface; extracellular space;
Biological process	detection of molecule of bacterial origin; lipid transport; toll-like receptor 4 signaling pathway; immune system process; leukocyte chemotaxis involved in inflammatory response; cellular defense response; cellular response to lipoteichoic acid; defense response to bacterium; lipopolysaccharide transport; positive regulation of interleukin-8 production; positive regulation of interleukin-6 production; positive regulation of neutrophil chemotaxis; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of chemokine production; negative regulation of tumor necrosis factor production; lipopolysaccharide-mediated signaling pathway; opsonization; defense response to Gram-negative bacterium; positive regulation of tumor necrosis factor production; response to lipopolysaccharide; macrophage activation involved in immune response; positive regulation of respiratory burst involved in inflammatory response; acute-phase response; innate immune response; defense response to Gram-positive bacterium; cellular response to lipopolysaccharide; positive regulation of macrophage activation; toll-like receptor signaling pathway; macromolecule localization; positive regulation of cytolysis; transport; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3929
	16803
	ENSG00000129988
	ENSMUSG00000016024
	P18428
	Q61805
	NM_004139
	NM_008489
	NP_004130
	NP_032515
	Wikidata
View/Edit Human	View/Edit Mouse

Lipopolysaccharide binding protein is a protein that in humans is encoded by the LBP gene.^[5]^[6]

LBP is a soluble acute-phase protein that binds to bacterial lipopolysaccharide (or LPS) to elicit immune responses by presenting the LPS to important cell surface pattern recognition receptors called CD14 and TLR4.^[7]

Template:PBB Summary

Interactions

Lipopolysaccharide-binding protein has been shown to interact with CD14, TLR2, TLR4 and the co-receptor MD-2.^[8]^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129988 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016024 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gray PW, Corcorran AE, Eddy RL Jr, Byers MG, Shows TB (March 1993). "The genes for the lipopolysaccharide binding protein (LBP) and the bactericidal permeability increasing protein (BPI) are encoded in the same region of human chromosome 20". Genomics. 15 (1): 188–90. doi:10.1006/geno.1993.1030. PMID 8432532.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Muta T, Takeshige K (2001). "Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor (TLR)2 as well as TLR4 Reconstitution of TLR2- and TLR4-activation by distinguishable ligands in LPS preparations". Eur. J. Biochem. 268 (16): 4580–9. doi:10.1046/j.1432-1327.2001.02385.x. PMID 11502220.
^ Thomas, Celestine J; Kapoor Mili; Sharma Shilpi; Bausinger Huguette; Zyilan Umit; Lipsker Dan; Hanau Daniel; Surolia Avadhesha (November 2002). "Evidence of a trimolecular complex involving LPS, LPS binding protein and soluble CD14 as an effector of LPS response". FEBS Lett. 531 (2). Netherlands: 184–8. doi:10.1016/S0014-5793(02)03499-3. ISSN 0014-5793. PMID 12417309. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Yu, B; Wright S D (1995). "LPS-dependent interaction of Mac-2-binding protein with immobilized CD14". J. Inflamm. 45 (2). UNITED STATES: 115–25. ISSN 1078-7852. PMID 7583357. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)
^ Erridge, C; Pridmore, A; Eley, A; Stewart, J; Poxton, IR (2004). "Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via toll-like receptor 2". Journal of Medical Microbiology. 53 (Pt 8): 735–40. doi:10.1099/jmm.0.45598-0. PMID 15272059.

External links

lipopolysaccharide-binding+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Template:PBB Controls

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129988 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016024 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8432532-5] Gray PW, Corcorran AE, Eddy RL Jr, Byers MG, Shows TB (March 1993). "The genes for the lipopolysaccharide binding protein (LBP) and the bactericidal permeability increasing protein (BPI) are encoded in the same region of human chromosome 20". Genomics. 15 (1): 188–90. doi:10.1006/geno.1993.1030. PMID 8432532.

[entrez-6] Cite error: The named reference entrez was invoked but never defined (see the help page).

[7] Muta T, Takeshige K (2001). "Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor (TLR)2 as well as TLR4 Reconstitution of TLR2- and TLR4-activation by distinguishable ligands in LPS preparations". Eur. J. Biochem. 268 (16): 4580–9. doi:10.1046/j.1432-1327.2001.02385.x. PMID 11502220.

[pmid12417309-8] Thomas, Celestine J; Kapoor Mili; Sharma Shilpi; Bausinger Huguette; Zyilan Umit; Lipsker Dan; Hanau Daniel; Surolia Avadhesha (November 2002). "Evidence of a trimolecular complex involving LPS, LPS binding protein and soluble CD14 as an effector of LPS response". FEBS Lett. 531 (2). Netherlands: 184–8. doi:10.1016/S0014-5793(02)03499-3. ISSN 0014-5793. PMID 12417309. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

[pmid7583357-9] Yu, B; Wright S D (1995). "LPS-dependent interaction of Mac-2-binding protein with immobilized CD14". J. Inflamm. 45 (2). UNITED STATES: 115–25. ISSN 1078-7852. PMID 7583357. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)

[pmid15272059-10] Erridge, C; Pridmore, A; Eley, A; Stewart, J; Poxton, IR (2004). "Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via toll-like receptor 2". Journal of Medical Microbiology. 53 (Pt 8): 735–40. doi:10.1099/jmm.0.45598-0. PMID 15272059.

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v t e Signaling pathway: TLR signaling pathway
TLRs	TLR1 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TLR10 TLR11 TLR12 TLR13
Other receptors	CD14 LBP MD2
Downstream signalling	IRAK1 IRAK2 IRAK3 IRAK4 IRF3 MAP3K7 MYD88 TAB1 TICAM1 TIRAP TOLLIP TRAF6

Interactions

References

Further reading

External links