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List of adverse effects of paroxetine

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This is a list of adverse effects of the antidepressant paroxetine, sorted by frequency of occurrence.[1][2][3][4]

Very common

Very common (>10% incidence) adverse effects include:

  • Nausea
  • Sexual dysfunction (including anorgasmia (difficulty achieving an orgasm), erectile dysfunction, genital anaesthesia, ejaculation disorder, loss of libido etc.). Paroxetine is associated with a higher rate of sexual dysfunction than other SSRIs.[5]
  • Impaired concentration
  • Somnolence is more common with paroxetine than with other SSRIs.[6]
  • Insomnia
  • Headache
  • Dry mouth

Common

Common (1–10% incidence) adverse effects include:

Uncommon

Uncommon (0.1–1% incidence) adverse effects include:

Rare

Rare (0.01–0.1% incidence) adverse effects include:

Very rare

Rare (<0.01% incidence) adverse effects include:

References

  1. ^ "PRODUCT INFORMATION PAROXETINE SANDOZ 20mg FILM-COATED TABLETS" (PDF). TGA eBusiness Services. Sandoz Pty Ltd. 18 January 2012. Retrieved 22 November 2013.
  2. ^ "PAROXETINE (paroxetine hydrochloride hemihydrate) tablet, film coated [Mylan Institutional Inc.]". DailyMed. Mylan Institutional Inc. January 2012. Retrieved 22 November 2013.
  3. ^ "Paroxetine 20 mg Tablets - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Sandoz Limited. 21 March 2013. Retrieved 22 November 2013.
  4. ^ "Paxil, Paxil CR (paroxetine) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 22 November 2013.
  5. ^ Taylor, D; Paton, C; Shitij, K (2012). The Maudsley prescribing guidelines in psychiatry. West Sussex: Wiley-Blackwell. ISBN 978-0-470-97948-8.{{cite book}}: CS1 maint: multiple names: authors list (link)
  6. ^ a b Ciraulo, DA; Shader, RI, eds. (2011). Pharmacotherapy of Depression (2nd ed.). New York, NY: Humana Press. doi:10.1007/978-1-60327-435-7. ISBN 978-1-60327-434-0. {{cite book}}: |work= ignored (help)
  7. ^ a b Vesely C, Fischer P, Goessler R, Kasper S (February 1997). "Mania associated with serotonin selective reuptake inhibitors". J Clin Psychiatry. 58 (2): 88. doi:10.4088/JCP.v58n0206e. PMID 9062382.
  8. ^ a b Ramasubbu R (2004). "Antidepressant treatment-associated behavioural expression of hypomania: a case series". Prog. Neuropsychopharmacol. Biol. Psychiatry. 28 (7): 1201–7. doi:10.1016/j.pnpbp.2004.06.015. PMID 15610935.
  9. ^ a b Grubbs JH (1997). "SSRI-induced mania". J Am Acad Child Adolesc Psychiatry. 36 (4): 445. doi:10.1097/00004583-199704000-00003. PMID 9100415.
  10. ^ "PAXIL (paroxetine hydrochloride) Tablets and Oral Suspension: PRESCRIBING INFORMATION" (PDF). Research Triangle Park, NC: GlaxoSmithKline. August 2007. Retrieved 2007-08-14.
  11. ^ Morishita S, Arita S (October 2003). "Induction of mania in depression by paroxetine". Hum Psychopharmacol. 18 (7): 565–8. doi:10.1002/hup.531. PMID 14533140.
  12. ^ Olivera AA (1996). "A case of paroxetine-induced akathisia". Biol. Psychiatry. 39 (10): 910. doi:10.1016/0006-3223(96)84504-5. PMID 8860197.
  13. ^ Baldassano CF, Truman CJ, Nierenberg A, Ghaemi SN, Sachs GS (1996). "Akathisia: a review and case report following paroxetine treatment". Compr Psychiatry. 37 (2): 122–4. doi:10.1016/S0010-440X(96)90572-6. PMID 8654061.
  14. ^ Tabachnick, Barbara (September 1998). "Sound Sensitivity" (PDF). Tinnitus Today. Retrieved 2013-10-30.
  15. ^ "Important Safety Information about Paxil CR". GlaxoSmithKline. Archived from the original on July 15, 2007. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  16. ^ Nishida T, Wada M, Wada M, Ito H, Narabayashi M, Onishi H (2008). "Activation syndrome caused by paroxetine in a cancer patient". Palliat Support Care. 6 (2): 183–5. doi:10.1017/S1478951508000278. PMID 18501054.
  17. ^ Ochiai Y, Katsu H, Okino S, Wakutsu N, Nakayama K (2003). "[Case of prolonged recovery from serotonin syndrome caused by paroxetine]". Seishin Shinkeigaku Zasshi (in Japanese). 105 (12): 1532–8. PMID 15027311.
  18. ^ Terao T, Hikichi T (2007). "Serotonin syndrome in a case of depression with various somatic symptoms: the difficulty in differential diagnosis". Prog. Neuropsychopharmacol. Biol. Psychiatry. 31 (1): 295–6. doi:10.1016/j.pnpbp.2006.07.007. PMID 16916568.
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