Macrogol
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| Formula | H-(OCH2CH2)n-OH |
| Molar mass | Not available |
Macrogol is the International Nonproprietary Name (INN) for polyethylene glycol. Macrogols have been used as laxatives, i.e. to treat constipation.[1]
They are also used as excipients in pharmaceutical products where lower molecular weight variants are used as solvents in oral liquids and soft capsules. Solid variants are used as ointment bases, tablet bindings, film coatings and lubricants.[2]
Types include:
The number represents the average molecular weight of the polyethylene glycol. Combining different molecular weights provides some control over the consistency.[2]
See also
Available forms
Macrogol (polyethylene glycol) is sold as non-prescription preparation in powder form under trade names SoftLax, Miralax, Glycoprep, Movicol, Macrogol (generic). It is dissolved in a glass of water to create a clear, tasteless and odorless solution and is swallowed.
References
- ^ Zangaglia R, Martignoni E, Glorioso M; et al. (2007). "Macrogol for the treatment of constipation in Parkinson's disease. A randomized placebo-controlled study". Mov. Disord. 22 (9): 1239–44. doi:10.1002/mds.21243. PMID 17566120.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ a b
Smolinske, Susan C. (1992). Handbook of Food, Drug, and Cosmetic Excipients. p. 287. ISBN 084933585X, 9780849335853.
{{cite book}}: Check|isbn=value: invalid character (help) - ^ "CID 27175 -- PubChem Compound Summary". Retrieved 2008-01-18.
- ^ Hardikar W, Cranswick N, Heine RG (2007). "Macrogol 3350 plus electrolytes for chronic constipation in children: a single-centre, open-label study". J Paediatr Child Health. 43 (7–8): 527–31. doi:10.1111/j.1440-1754.2007.01116.x. PMID 17635680.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Hyry H, Vuorio A, Varjonen E, Skyttä J, Mäkinen-Kiljunen S (2006). "Two cases of anaphylaxis to macrogol 6000 after ingestion of drug tablets". Allergy. 61 (8): 1021. doi:10.1111/j.1398-9995.2006.01083.x. PMID 16867059.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
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