Mebicar

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Mebicar
Mebicar.svg
Legal status
Legal status
  • US: Unscheduled; not FDA approved
Pharmacokinetic data
Biological half-life 3h[1]
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C8H14N4O2
Molar mass 198.23 g·mol−1
3D model (JSmol)

Mebicar (mebicarum) is an anxiolytic medication produced by Latvian pharmaceutical company Olainfarm and sold in Latvia and Russia under the brand name Adaptol.[2] Mebicar is not approved for use in the United States.

Mebicar has an effect on the structure of limbic-reticular activity, particularly on hypothalamus emotional zone, as well as on all 4 basic neuromediator systems – γ aminobutyric acid (GABA), choline, serotonin and adrenergic activity. Mebicar decreases the brain noradrenaline level, exerts no effect on the dopaminergic systems, increases the brain serotonin level, and does not elicit cholinolytic action.[3]

Mebicar purportedly has anti-anxiety (anxiolytic) properties.[3][4][5][6][7] It is also used to aid smoking cessation.[2] In addition, mebicar may be useful in the treatment of ADHD symptoms.[8] In contrast with typical anxiolytic medications such as benzodiazepines, mebicar is non-habit forming, non-sedating and does not impair motor function.[4][2]

See also[edit]

References[edit]

  1. ^ Schwarz, Joseph; Weisspapir, Michael. "Sustained release pharmaceutical composition containing mebicar". Retrieved 20 June 2017. 
  2. ^ a b c Adaptol product summary http://olainfarm.lv/en/prescription-drugs/adaptol-3
  3. ^ a b Val'Dman, AV; Zaikonnikova, IV; Kozlovskaia, MM; Zimakova, IE (1980). "Characteristics of the psychotropic spectrum of action of mebicar". Biulleten' eksperimental'noi biologii i meditsiny. 89 (5): 568–70. PMID 6104993. 
  4. ^ a b Val'Dman, A. V.; Zaikonnikova, I. V.; Kozlovskaya, M. M.; Zimakova, I. E. (1980). "A study of the spectrum of psychotropic action of mebicar". Bulletin of Experimental Biology and Medicine. 89 (5): 621. doi:10.1007/BF00835799. 
  5. ^ Mkrtchian, VR; Kozhokova, LZ (2012). "Adaptol--verges of possible". Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukrainy (5): 125–33. PMID 23534281. 
  6. ^ Chutko, LS; Rozhkova, AV; Sidorenko, VA; Surushkina, SIu; Tursunova, KB (2012). "Generalized anxiety disorder: Psychosomatic aspects and treatment approaches". Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov \i] Vserossiiskoe obshchestvo psikhiatrov. 112 (1): 40–4. PMID 22678674. 
  7. ^ Chutko, LS; Surushkina, SIu; Nikishena, IS; Iakovenko, EA; Anisimova, TI; Kuzovenkova, MP (2010). "Asthenic disorders in children". Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov \i] Vserossiiskoe obshchestvo psikhiatrov. 110 (11 Pt 1): 26–9. PMID 21183919. 
  8. ^ Chutko, LS; Surushkina, SIu; Nikishena, IS; Iakovenko, EA; Anisimova, TI; Sergeev, AV (2009). "Adaptol in the treatment of ADHD". Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov \i] Vserossiiskoe obshchestvo psikhiatrov. 109 (8): 45–8. PMID 19738569.