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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Protein PFKFB1 PDB 1c7z.png
PDB rendering based on 1c7z.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PFKFB1 ; F6PK; HL2K; PFRX
External IDs OMIM311790 MGI107816 HomoloGene105654 GeneCards: PFKFB1 Gene
EC number,
RNA expression pattern
PBB GE PFKFB1 207537 at tn.png
More reference expression data
Species Human Mouse
Entrez 5207 18639
Ensembl ENSG00000158571 ENSMUSG00000025271
UniProt P16118 P70266
RefSeq (mRNA) NM_001271804 NM_008824
RefSeq (protein) NP_001258733 NP_032850
Location (UCSC) Chr X:
54.93 – 55 Mb
Chr X:
150.59 – 150.64 Mb
PubMed search [1] [2]

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.[1][2]

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.[2]


  1. ^ Batra RS, Hatchwell E, Rider S, Brown R, Brown GK, Craig IW (Apr 1997). "Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21". Genomics 40 (2): 358–61. doi:10.1006/geno.1996.4530. PMID 9119406. 
  2. ^ a b "Entrez Gene: PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1". 

Further reading[edit]