PFKFB1

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PFKFB1
Protein PFKFB1 PDB 1c7z.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PFKFB1, F6PK, HL2K, PFRX, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
External IDs MGI: 107816 HomoloGene: 105654 GeneCards: 5207
RNA expression pattern
PBB GE PFKFB1 207537 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001271804
NM_001271805
NM_002625

NM_008824

RefSeq (protein)

NP_001258733.1
NP_001258734.1
NP_002616.2

NP_032850.1

Location (UCSC) Chr X: 54.93 – 55 Mb Chr X: 150.59 – 150.64 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.[3][4]

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Batra RS, Hatchwell E, Rider S, Brown R, Brown GK, Craig IW (Apr 1997). "Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21". Genomics. 40 (2): 358–61. doi:10.1006/geno.1996.4530. PMID 9119406. 
  4. ^ a b "Entrez Gene: PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1". 

Further reading[edit]