PFKFB1

PFKFB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K6M
Identifiers
Aliases	PFKFB1, F6PK, HL2K, PFRX, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
External IDs	OMIM: 311790 MGI: 107816 HomoloGene: 105654 GeneCards: PFKFB1
Gene location (Human)
Chr.	X chromosome (human)
End	54,998,534 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	149,426,874 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gastrocnemius muscle; ; vastus lateralis muscle; ; biceps brachii; ; triceps brachii muscle; ; deltoid muscle; ; adipose tissue; ; subcutaneous adipose tissue; ; abdominal fat; ; tibialis anterior muscle;
	Top expressed in
	sternocleidomastoid muscle; ; vastus lateralis muscle; ; triceps brachii muscle; ; masseter muscle; ; tibialis anterior muscle; ; temporal muscle; ; digastric muscle; ; gastrocnemius muscle; ; right ventricle; ; plantaris muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; fructose-6-phosphate binding; kinase activity; catalytic activity; protein binding; identical protein binding; fructose-2,6-bisphosphate 2-phosphatase activity; hydrolase activity; ATP binding; 6-phosphofructo-2-kinase activity; kinase binding;
Cellular component	cytosol; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex;
Biological process	gluconeogenesis; response to glucagon; glycolytic process; phosphorylation; fructose metabolic process; response to glucocorticoid; carbohydrate phosphorylation; response to insulin; positive regulation of glucokinase activity; fructose 2,6-bisphosphate metabolic process; animal organ regeneration; response to starvation; metabolism; response to cAMP; dephosphorylation; negative regulation of glycolytic process; positive regulation of glycolytic process;
	Sources:Amigo / QuickGO
Orthologs
	5207
	18639
	ENSG00000158571
	ENSMUSG00000025271
	P16118
	P70266
	NM_001271804; NM_001271805; NM_002625
NM_008824; NM_001374170; NM_001374171; NM_001374172; NM_001374173;
	NM_001374175
	NP_001258733; NP_001258734; NP_002616
NP_032850; NP_001361099; NP_001361100; NP_001361101; NP_001361102;
	NP_001361104
	Wikidata
View/Edit Human	View/Edit Mouse

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158571 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025271 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Batra RS, Hatchwell E, Rider S, Brown R, Brown GK, Craig IW (Apr 1997). "Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21". Genomics. 40 (2): 358–61. doi:10.1006/geno.1996.4530. PMID 9119406.
^ "Entrez Gene: PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1".

References

Further reading