Azinger won eleven tournaments on the PGA Tour in seven seasons from 1987 to 1993, climaxing in his one major title, the 1993 PGA Championship at Inverness, which he won in a sudden-death playoff against Greg Norman.
Azinger finished one shot behind Nick Faldo at the 1987 Open Championship at Muirfield after making bogey at both the 71st and 72nd holes. Azinger was bidding to become only the fourth golfer since 1945 to win the British Open at the first attempt and said that he was "heartbroken" to leave Muirfield without the Claret Jug trophy.
In December 1993, Azinger was diagnosed with non-Hodgkin lymphoma in his right shoulder. His treatment included six months of chemotherapy and five weeks of radiation in California. He wrote a book called Zinger about his battle with the disease and was the recipient of GWAA Ben Hogan Award in 1995, given to the individual who has continued to be active in golf despite physical handicap or serious illness. In 2000, he won his first tournament in seven seasons at the Sony Open in Hawaii.
Azinger was the U.S. Ryder Cup captain for the 2008 at Valhalla Golf Club in Louisville, Kentucky. He led the team to its first victory over the European squad since 1999. The team's victory was largely credited to his innovative strategy. This strategy is outlined in his book, Cracking the Code: The Winning Ryder Cup Strategy: Make it Work for You, which was released in May 2010. The book was co-authored with Ron Braund, a corporate team builder and psychologist, who consulted Azinger throughout the Ryder Cup.
Since 2005, Azinger has worked as a color commentator for ESPN and ABC Sports' golf coverage. He initially shared color commentating duties with his former Ryder Cup and British Open rival Nick Faldo. Azinger and Faldo, along with host Mike Tirico, formed one of the most widely praised broadcast teams in televised golf history. Faldo left for rival CBS after the 2006 season. Since then, Azinger has worked alone with Tirico. However, when Faldo and Azinger were opposing captains at the 2008 Ryder Cup, Azinger's colleague Andy North filled in for him. Faldo and Azinger have also reunited as analysts on two occasions, one for each other's network. The first reunion was at the 2007 Open Championship (for ABC) and the second was at the 2009 Presidents Cup (for the Golf Channel).
Azinger is a Christian. He and his wife Toni met at FSU and have been married since 1982. They have two daughters, Sarah Jean Collins and Josie Lyn, and currently live in Bradenton, Florida.
Azinger gave the eulogy at the memorial service for his friend Payne Stewart, who was killed in a plane crash in 1999. His two managers and close friends, Robert Fraley and Van Ardan, also died in the crash.