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Peter St George-Hyslop

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Peter Henry St George-Hyslop (born July 10, 1953) is a British and Canadian medical scientist, neurologist and molecular geneticist who is known for his research into neurodegenerative diseases. St George-Hyslop is one of the most cited authors in the field of Alzheimer's disease research.[1] He has identified a number of key genes that are responsible for nerve cell degeneration and early-onset forms of Alzheimer's disease. These include the discovery of the presenilins (PSEN1 and PSEN2),[2] Nicastrin,[3] TREM2,[4] Apolipoprotein E[5] and SORL1[6] genes. Presenilin mutations are the most common cause of familial Alzheimer's disease.[7] St George-Hyslop also co-led the discovery of the gene for the amyloid precursor protein.[8]

St George-Hyslop's father, Noel St George Hyslop was a renowned scientist who worked on Foot and Mouth Disease virus.

Since 2007 St George-Hyslop has headed an Alzheimer's disease research program as Professor of Experimental Neuroscience at the University of Cambridge.[9][10]

Educated at Wellington School, Wellington, Somerset, UK, St George-Hyslop completed his medical training in Canada, graduating with the MD degree in 1976, and then pursuing post-doctoral research in internal medicine and neurology at the University of Toronto and Harvard Medical School. He served his first appointment at Harvard's Massachusetts General Hospital, where he taught molecular genetics and neurology from 1987 to 1991. He was appointed to the University of Toronto in 1991, and since 2003 has held the university's highest rank of University Professor. From 1995 to 2018, St George-Hyslop served as the director of the Tanz Centre for Research in Neurodegenerative Diseases at the University of Toronto Faculty of Medicine.[11][12] In 2007 St George-Hyslop was appointed Professor of Experimental Neuroscience at the University of Cambridge.

He was awarded the Metlife Foundation Award for Medical Research in Alzheimer's Disease in 1987,[13] the Howard Hughes Medical Institute International Scholar Award in 1997 and 2002, the Gold Medal in Medicine from the Royal College of Physicians of Canada in 1994, the Michael Smith Award from the Canadian Institutes of Health Research in 1997 and the Dan David Prize in 2014.[14] He is a member of the American Society for Clinical Investigation, a fellow of the Royal Society of London and the Royal Society of Canada, and a Foreign Member to the Institute of Medicine of the United States National Academies. He was appointed Officer of the Order of Canada in 2018.[15]

References

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  1. ^ "Science.ca : Peter Henry St. George-Hyslop".
  2. ^ "Cloning of a novel gene bearing missense mutations in early onset familial Alzheimer Disease". Nature.
  3. ^ "Nicastrin modulates presenilin-mediated Notch/Gip1 signal transduction and bAPP processing". Nature.
  4. ^ "TREM2 variants in Alzheimer's disease". New England Journal of Medicine. PMC 3631573.
  5. ^ "Association of Apoliprotein E allele e4 with the late-onset familial and sporadic Alzheimer Disease". Neurology.
  6. ^ "The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer's Disease". Nature Genetics. PMC 2657343.
  7. ^ "Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease". Neural Regeneration Research. PMID 34100423.
  8. ^ "A Hundred Years of Alzheimer's Disease Research". Neuron. PMID 17015223.
  9. ^ "Horizons magazine". 19 February 2013.
  10. ^ "Prof Peter St George-Hyslop". www.cimr.cam.ac.uk. Archived from the original on 2007-11-09.
  11. ^ "About the Centre | Tanz Centre for Research in Neurodegenerative Diseases".
  12. ^ "Director's Message | Tanz Centre for Research in Neurodegenerative Diseases". tanz.med.utoronto.ca.
  13. ^ "MetLife Foundation Awards for Medical Research in Alzheimer's Disease" (PDF). Archived from the original (PDF) on 13 October 2018.
  14. ^ "Dan David Foundation announces winners of prize". The Jerusalem Post | JPost.com. 11 February 2014. Retrieved 2020-11-02.
  15. ^ "Order of Canada Appointments". 29 June 2018. Archived from the original on 29 September 2020. Retrieved 18 February 2019.

Further reading

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