T-lymphoblastic leukemia/lymphoma

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T-lymphoblastic leukemia/lymphoma

T-lymphoblastic leukemia/lymphoma (WHO 2008),[1]:219 previously labeled precursor T-lymphoblastic leukemia/lymphoma (WHO 2001)[1]:219 and also known as precursor T-cell lymphoblastic lymphoma and precursor T acute lymphoblastic leukemia/lymphoma is a form of lymphoid leukemia[2][3] and lymphoma[4] in which too many T-cell lymphoblasts (immature white blood cells) are found in the blood, bone marrow, and tissues, particularly mediastinal lymph nodes.[1]:635 Labeling as leukemia or lymphoma depends on which feature is more pronounced in a given situation, but has no biological or treatment implication.[1]:635

It is uncommon in adults, but represents 15% of childhood acute lymphoblastic leukemia and 90% of lymphoblastic lymphoma.[1]:635

The 2008 terminology dropped "precursor" to avoid linguistic redundancy because the lymphoblast is an immature precursor cell by definition.[1]:219


  1. ^ a b c d e f Jaffe ES, Harris NL, Vardiman JW, Campo E, Arber, DA (2011). Hematopathology (1st ed.). Elsevier Saunders. ISBN 9780721600406. 
  2. ^ Kim MA, Lee GW, Maeng KY (August 2005). "An unusual presenting feature of precursor T-cell acute lymphoblastic leukemia/lymphoma". Ann. Hematol. 84 (8): 553–4. doi:10.1007/s00277-005-1042-4. PMID 15843931. 
  3. ^ Lyman MD, Neuhauser TS (April 2002). "Precursor T-cell acute lymphoblastic leukemia/lymphoma involving the uterine cervix, myometrium, endometrium, and appendix". Ann Diagn Pathol. 6 (2): 125–8. doi:10.1053/adpa.2002.32381. PMID 12004362. 
  4. ^ Han X, Bueso-Ramos CE (April 2007). "Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias". Am. J. Clin. Pathol. 127 (4): 528–44. doi:10.1309/2QE3A6EKQ8UYDYRC. PMID 17369128. [permanent dead link]

 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".

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