She was born in Cape Town, South Africa, on May 11, 1942. She was a pupil of concert pianist Gina Bachauer and, for a while, she was a professional concert pianist herself. After her brother was dethroned, she moved to India with her mother. Since her mother's death, Princess Irene has lived in Spain in an apartment at the La Zarzuela Palace in Madrid, the royal residence of the King and Queen of Spain. Her niece, Infanta Cristina of Spain named her daughter Irene (born in 2005) after her. Princess Irene has never married and is close to her brother, Constantine.
She is the founder and president of the World in Harmony Organization (Mundo en Armonía [1]) and also collaborates with other benefic foundations and cultural activities.