The PR-165 begins in the PR-164 (road from Naranjito to Corozal) and ends at San Patricio (near Caparra). From Naranjito to Toa Alta is a rural road. In Toa Baja becomes a divided highway. In Dorado the road is one lane in each direction and parallel to the northern coast of Puerto Rico. In Levittown becomes a divided highway before ending at San Patricio. In Cataño is a short highway which begins at the Bacardi Distillery and ends at the Federal Prison.